Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer

(2021) Nina G Steele et al.   CLINICAL CANCER RESEARCH

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions

(2021) Gianluca Mucciolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAS drives immune evasion in a genetic model of pancreatic cancer

(2021) Irene Ischenko et al.   Nature Communications

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

(2021) Heming Ge et al.   Frontiers in Oncology

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

(2021) George Sharbeen et al.   CANCER RESEARCH

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

(2021) Kyösti Tahkola et al.   Scientific Reports

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Myc instructs and maintains pancreatic adenocarcinoma phenotype

(2020) Nicole M Sodir et al.   Cancer Discovery

Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment

(2020) Prasenjit Dey et al.   Cancer Discovery

SnapShot: Cancer-Associated Fibroblasts

(2020) Danielle Park et al.   CELL

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

(2020) Sohinee Bhattacharyya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pancreatic cancer stroma: an update on therapeutic targeting strategies

(2020) Abdel N. Hosein et al.   Nature Reviews Gastroenterology & Hepatology

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

(2020) Tim DD Somerville et al.   eLife

CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma

(2020) Toshihiro Morita et al.   CANCER RESEARCH

Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

(2020) Megan R. Chastney et al.   JOURNAL OF CELL BIOLOGY

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

(2020) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes

(2020) Koji Miyabayashi et al.   Cancer Discovery

Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition

(2020) Arthur Brannon et al.   Scientific Reports

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen

(2020) Yurina Ogawa et al.   CLINICAL CANCER RESEARCH

Mesenchymal plasticity regulated by Prrx1 drives aggressive pancreatic cancer biology

(2020) Karin Feldmann et al.   GASTROENTEROLOGY

Safety and Efficacy of Andecaliximab ( GS ‐5745) Plus Gemcitabine and Nab‐Paclitaxel in Patients with Advanced Pancreatic Adenocarcinoma: Results from a Phase I Study

(2020) Johanna Bendell et al.   ONCOLOGIST

PDX-derived organoids model in vivo drug response and secrete biomarkers

(2020) Ling Huang et al.   JCI Insight

Gemcitabine/nab-paclitaxel with pamrevlumab: a novel drug combination and trial design for the treatment of locally advanced pancreatic cancer

(2020) Vincent Picozzi et al.   ESMO Open

Responsive and activable nanomedicines for remodeling the tumor microenvironment

(2020) Yinlong Zhang et al.   Nature Protocols

Carbohydrate antigen 19-9 — tumor marker: Past, present, and future

(2020) Tsinrong Lee et al.   World Journal of Gastrointestinal Surgery

Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes

(2019) Hans Carlo Maurer et al.   GUT

Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix

(2019) Kaoru Miyazaki et al.   Scientific Reports

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

(2019) Francesca R. Auciello et al.   Cancer Discovery

Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313

(2019) Ramesh K. Ramanathan et al.   JOURNAL OF CLINICAL ONCOLOGY

Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets

(2019) Martin C. Whittle et al.   GASTROENTEROLOGY

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

(2019) Hong Jiang et al.   GUT

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

(2019) Yu Shi et al.   NATURE

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

(2019) Noor Jailkhani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

(2019) Matteo Ligorio et al.   CELL

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

(2019) Junya Peng et al.   CELL RESEARCH

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

(2019) Claire S Reader et al.   JOURNAL OF PATHOLOGY

Tumor priming by SMO inhibition enhances antibody delivery and efficacy in a pancreatic ductal adenocarcinoma model

(2019) Jun Wang et al.   MOLECULAR CANCER THERAPEUTICS

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells

(2019) Laia Gorchs et al.   Frontiers in Immunology

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

(2019) Chenxi Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

(2019) Amelie Juin et al.   DEVELOPMENTAL CELL

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

(2019) Else Driehuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

(2019) Nicholas Willumsen et al.   Scientific Reports

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

(2018) Claire Vennin et al.   GASTROENTEROLOGY

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

(2018) Jingjing Liu et al.   Nano Today

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

(2018) James R.W. Conway et al.   Cell Reports

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

(2018) Xuexiang Han et al.   Nature Communications

Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma

(2018) Kianna Y. Elahi-Gedwillo et al.   CANCER RESEARCH

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

(2018) Vincent Bernard et al.   CLINICAL CANCER RESEARCH

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

(2018) Ujjwal Mukund Mahajan et al.   GASTROENTEROLOGY

Necuparanib, a multi-targeting heparan sulfate mimetic, targets tumor and stromal compartments in pancreatic cancer

(2018) Amanda MacDonald et al.   MOLECULAR CANCER THERAPEUTICS

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

(2018) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

(2018) David Novo et al.   Nature Communications

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

(2018) Andreia V. Pinho et al.   Nature Communications

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

(2018) Roberto Moreno-Vicente et al.   Cell Reports

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function

(2017) D R Principe et al.   ONCOGENE

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts

(2017) Max Nobis et al.   Cell Reports

Locally Advanced Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary

(2017) Edward P. Balaban et al.   Journal of Oncology Practice

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

(2016) Andrew H. Ko et al.   PANCREAS

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

(2016) M. Waghray et al.   Cancer Discovery

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

(2015) Daniel V.T. Catenacci et al.   JOURNAL OF CLINICAL ONCOLOGY

nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial

(2015) D. Goldstein et al.   JNCI-Journal of the National Cancer Institute

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma

(2015) Lai Mun Wang et al.   Oncotarget

nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial

(2015) D. Goldstein et al.   JNCI-Journal of the National Cancer Institute

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Recent progress in pancreatic cancer

(2013) Christopher L. Wolfgang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

nab-Paclitaxel mechanisms of action and delivery

(2013) Denise A. Yardley   JOURNAL OF CONTROLLED RELEASE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

(2011) P. Timpson et al.   CANCER RESEARCH

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

(2011) Paul Timpson et al.   Jove-Journal of Visualized Experiments

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

Margin Clearance and Outcome in Resected Pancreatic Cancer

(2009) David K. Chang et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Focal adhesion kinase as a regulator of cell tension in the progression of cancer

(2007) Robert W. Tilghman et al.   SEMINARS IN CANCER BIOLOGY