Responsive and activable nanomedicines for remodeling the tumor microenvironment

Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages

(2019) Muhammad Ovais et al.   ADVANCED MATERIALS

An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy

(2019) Xuexiang Han et al.   ACS Nano

Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice

(2019) Julia Volz et al.   BLOOD

Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery

(2019) Manju Kanamala et al.   Nanomedicine

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting the microenvironment in solid tumors

(2018) Carmen Belli et al.   CANCER TREATMENT REVIEWS

Immune suppression and reversal of the suppressive tumor microenvironment

(2018) Kanako Shimizu et al.   INTERNATIONAL IMMUNOLOGY

Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles

(2018) Yimin Niu et al.   JOURNAL OF CONTROLLED RELEASE

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

(2018) Jingjing Liu et al.   Nano Today

Recent advances in developing novel anti-cancer drugs targeting tumor hypoxic and acidic microenvironments

(2018) Weidong Li et al.   Recent Patents on Anti-Cancer Drug Discovery

Stimuli-responsive liposomes for drug delivery

(2017) Y. Lee et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis

(2017) Yinlong Zhang et al.   Theranostics

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

(2017) Suping Li et al.   Nature Biomedical Engineering

pH-activated size reduction of large compound nanoparticles for in vivo nucleus-targeted drug delivery

(2016) Yanbin Fan et al.   BIOMATERIALS

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

(2016) Lei Miao et al.   CANCER RESEARCH

High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma

(2016) Nada Salem et al.   Future Oncology

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

(2016) YAO YUAN et al.   ONCOLOGY REPORTS

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas

(2016) A. H. Long et al.   Cancer Immunology Research

Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice

(2015) Huan Meng et al.   ACS Nano

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications

(2013) Tianjiao Ji et al.   ADVANCED MATERIALS

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

Targeting platelet function to improve drug delivery

(2012) Mélanie Demers et al.   OncoImmunology

Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles

(2011) Hai Wang et al.   BIOMATERIALS

Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice

(2011) M. Demers et al.   CANCER RESEARCH

How platelets safeguard vascular integrity

(2011) B. HO-TIN-NOÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Preparation of Multifunctional Drug Carrier for Tumor-Specific Uptake and Enhanced Intracellular Delivery through the Conjugation of Weak Acid Labile Linker

(2009) Caixia Ding et al.   BIOCONJUGATE CHEMISTRY

All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control

(2009) Kyong Mi Park et al.   BIOMATERIALS

Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery

(2009) Asmaa Elbakry et al.   NANO LETTERS

Gold Nanoparticles Capped with Polyethyleneimine for Enhanced siRNA Delivery

(2009) Wen-Jing Song et al.   Small

Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage

(2008) B. Ho-Tin-Noe et al.   CANCER RESEARCH