Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy

(2021) Wentao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

(2021) Michael Heider et al.   MOLECULAR CELL

Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL

(2021) Matthew A Nix et al.   Cancer Discovery

The therapeutic landscape for cells engineered with chimeric antigen receptors

(2020) Matthew MacKay et al.   NATURE BIOTECHNOLOGY

Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia

(2020) Matthew R. Lowerison et al.   Scientific Reports

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

(2020) Johanna Theruvath et al.   NATURE MEDICINE

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes

(2020) Kevin K. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of B7-H3 expression on tumour-infiltrating immune cells and clinicopathological characteristics in non–small-cell lung cancer

(2020) Jeemin Yim et al.   EUROPEAN JOURNAL OF CANCER

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

(2020) Meenakshi Hegde et al.   Nature Communications

A Quantitative Proteome Map of the Human Body

(2020) Lihua Jiang et al.   CELL

B7-H3: an attractive target for antibody-based immunotherapy

(2020) Filippos Kontos et al.   CLINICAL CANCER RESEARCH

Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer

(2020) Juniper A Scribner et al.   MOLECULAR CANCER THERAPEUTICS

CAR T cells targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

(2019) Robbie G. Majzner et al.   CLINICAL CANCER RESEARCH

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

(2019) Francesca Finotello et al.   Genome Medicine

Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7

(2019) Wu Di et al.   Cell Death & Disease

Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells

(2019) Davide Ceresa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

(2019) Yu Si et al.   Science Immunology

The PD-L1/PD-1 axis expression on tumor-infiltrating immune cells and tumor cells in pediatric rhabdomyosarcoma

(2019) Anna Gabrych et al.   PATHOLOGY RESEARCH AND PRACTICE

PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study

(2018) Giulia Bertolini et al.   BMC CANCER

B7-H3 in tumors: friend or foe for tumor immunity?

(2018) Gen Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis

(2018) Qinglian Tang et al.   ONCOGENE

Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer

(2018) John K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

(2018) Alexander J Martinko et al.   eLife

New B7 Family Checkpoints in Human Cancers

(2017) Ling Ni et al.   MOLECULAR CANCER THERAPEUTICS

Cancer cell‑expressed B7‑H3 regulates the differentiation of tumor‑associated macrophages in human colorectal carcinoma

(2017) Yong Mao et al.   Oncology Letters

Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells

(2016) RONGHUI LI et al.   Molecular Medicine Reports

Transcriptomics resources of human tissues and organs

(2016) M. Uhlen et al.   Molecular Systems Biology

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

freeQuant: A Mass Spectrometry Label-Free Quantification Software Tool for Complex Proteome Analysis

(2015) Ning Deng et al.   TheScientificWorldJOURNAL

freeQuant: A Mass Spectrometry Label-Free Quantification Software Tool for Complex Proteome Analysis

(2015) Ning Deng et al.   Scientific World Journal

A novel subset of B7-H3+CD14+HLA-DR−/lowmyeloid-derived suppressor cells are associated with progression of human NSCLC

(2015) Guangbo Zhang et al.   OncoImmunology

Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression

(2014) FU-BIAO KANG et al.   ONCOLOGY REPORTS

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

PAX-FOXO1fusion status drives unfavorable outcome for children with rhabdomyosarcoma: A children's oncology group report

(2013) Stephen X. Skapek et al.   PEDIATRIC BLOOD & CANCER

Eph/ephrin signalling during development

(2012) R. Klein   DEVELOPMENT

Cancer Cells Exploit the Eph-Ephrin System to Promote Invasion and Metastasis: Tales of Unwitting Partners

(2011) B. Wang   Science Signaling

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer

(2010) L. Cao et al.   CANCER RESEARCH

Long-term Cause-Specific Mortality Among Survivors of Childhood Cancer

(2010) Raoul C. Reulen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

(2009) Bernd Wollscheid et al.   NATURE BIOTECHNOLOGY

R-Cadherin Expression Inhibits Myogenesis and Induces Myoblast Transformation via Rac1 GTPase

(2008) J. Kucharczak et al.   CANCER RESEARCH