Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy

Proteogenomic and metabolomic characterization of human glioblastoma

(2021) Liang-Bo Wang et al.   CANCER CELL

Spatial profiling technologies and applications for brain cancers

(2021) Priyakshi Kalita-de Croft et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

(2021) Natalia Ochocka et al.   Nature Communications

Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

(2021) Atsuhito Uneda et al.   Acta Neuropathologica Communications

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Infiltration of CD163-positive macrophages in glioma tissues after treatment with anti-PD-L1 antibody and role of PI3Kγ inhibitor as a combination therapy with anti-PD-L1 antibody in in vivo model using temozolomide-resistant murine glioma-initiating cells

(2020) Tsubasa Miyazaki et al.   Brain Tumor Pathology

Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors

(2020) Sanford P. C. Hsu et al.   JOURNAL OF NEURO-ONCOLOGY

Extracellular Vesicles in Glioblastoma Tumor Microenvironment

(2020) Anuroop Yekula et al.   Frontiers in Immunology

NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

(2020) Rahul Suresh et al.   Journal for ImmunoTherapy of Cancer

Tumor‐associated macrophage interleukin‐β promotes glycerol‐3‐phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells

(2020) Jian Lu et al.   CANCER SCIENCE

Targeting macrophages: a novel avenue for cancer drug discovery

(2020) Sahana Kumar et al.   Expert Opinion on Drug Discovery

Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

(2020) Bhavesh K. Ahir et al.   MOLECULAR NEUROBIOLOGY

Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma

(2020) Hélène Grégoire et al.   Frontiers in Pharmacology

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

(2020) David A. Reardon et al.   JAMA Oncology

Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives

(2020) Bas Weenink et al.   Cancers

PD-1 inhibitors: Do they have a future in the treatment of glioblastoma?

(2020) Mustafa Khasraw et al.   CLINICAL CANCER RESEARCH

Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells

(2020) Ganesh Rao et al.   CLINICAL CANCER RESEARCH

Progress and applications of single-cell sequencing techniques

(2020) Aimaiti Yasen et al.   INFECTION GENETICS AND EVOLUTION

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

(2020) Leila Akkari et al.   Science Translational Medicine

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

(2020) Weiwei Tao et al.   Nature Communications

Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma

(2020) Anne Blank et al.   JOURNAL OF PATHOLOGY

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

(2020) Astrid De Boeck et al.   Nature Communications

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma

(2019) Gregor Hutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12

(2019) Frank Giordano et al.   Cancers

Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF)

(2019) Wendy Ha et al.   Scientific Reports

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 loss of function in glioblastoma

(2019) Shuli Xia et al.   CANCER RESEARCH

Molecular Profiling of the Tumor Microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival

(2019) Marko Gjorgjevski et al.   BIOSCIENCE REPORTS

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

(2019) Dongsheng Yuan et al.   Cell Communication and Signaling

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell–specific chemokine recruitment of T cells and microglia

(2019) Xiaofan Guo et al.   NEURO-ONCOLOGY

The expression of CD40 correlates negatively with overall- and progression free survival of low- and high-grade gliomas

(2019) Jan-Michael Werner et al.   World Neurosurgery

Characterization of transcriptome profile and clinical features of a novel immunotherapy target CD204 in diffuse glioma

(2019) Yongliang Yuan et al.   Cancer Medicine

Molecular and clinical characterization of CD163 expression via large-scale analysis in glioma

(2019) Shasha Liu et al.   OncoImmunology

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Humanized immune system mouse models: progress, challenges and opportunities

(2019) Todd M. Allen et al.   NATURE IMMUNOLOGY

A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

(2019) Yanxian Feng et al.   Nature Communications

Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure

(2019) Marta Guerra-Rebollo et al.   Scientific Reports

Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma

(2019) Reena P Thomas et al.   CLINICAL CANCER RESEARCH

Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth

(2019) Jiping Wang et al.   GLIA

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

(2019) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

(2019) Mingyu Qian et al.   ONCOGENE

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

(2019) Ioannis Kaffes et al.   OncoImmunology

CYR61, a potential biomarker of tumor inflammatory response in epithelial ovarian cancer microenvironment of tumor progress

(2019) Jun Shi et al.   BMC CANCER

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

(2019) Xiang Zhang et al.   LABORATORY INVESTIGATION

CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2

(2019) Caren Yu-Ju Wu et al.   NEURO-ONCOLOGY

Immune biology of glioma associated macrophages and microglia: Functional and therapeutic implications

(2019) Jun Wei et al.   NEURO-ONCOLOGY

CCN1 stimulated the osteoblasts via PTEN/AKT/GSK3 β /cyclinD1 signal pathway in Myeloma Bone Disease

(2019) Siyang Yan et al.   Cancer Medicine

Immune landscapes associated with different glioblastoma molecular subtypes

(2019) Maria Martinez-Lage et al.   Acta Neuropathologica Communications

CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells

(2019) Roxana Solga et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

(2019) Sangeeta Goswami et al.   NATURE MEDICINE

Anti–PD-L1 antibody direct activation of macrophages contributes to a radiation-induced abscopal response in glioblastoma

(2019) Chibawanye I Ene et al.   NEURO-ONCOLOGY

Macrophage exclusion after radiation therapy (MERT): A new and effective way to increase the therapeutic ratio of radiotherapy

(2019) J Martin Brown et al.   RADIOTHERAPY AND ONCOLOGY

Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization

(2018) Theresa Barberi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Disrupting CD47-SIRPα axis alone or combined with autophagy depletion for the therapy of glioblastoma

(2018) Xuyao Zhang et al.   CARCINOGENESIS

Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma

(2018) Eudocia Q Lee et al.   CLINICAL CANCER RESEARCH

T-cell Dysfunction in Glioblastoma: Applying a New Framework

(2018) Karolina I. Woroniecka et al.   CLINICAL CANCER RESEARCH

T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

(2018) Karolina Woroniecka et al.   CLINICAL CANCER RESEARCH

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ten-year survival in glioblastoma. A systematic review

(2018) Tomasz Tykocki et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

(2018) Katia Mangano et al.   Oncotarget

The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model

(2018) IlKyoo Koh et al.   Scientific Reports

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

(2018) Konrad Gabrusiewicz et al.   OncoImmunology

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Humanized Mice for the Study of Immuno-Oncology

(2018) Philippe De La Rochere et al.   TRENDS IN IMMUNOLOGY

Radiogenomics Profiling for Glioblastoma-related Immune Cells Reveals CD49d Expression Correlation with MRI parameters and Prognosis

(2018) Hye Rim Cho et al.   Scientific Reports

Difference in Immunosuppressive Cells Between Peritumoral Area and Tumor Core in Glioblastoma

(2018) Ryota Tamura et al.   World Neurosurgery

CD73 as a potential opportunity for cancer immunotherapy

(2018) Ghasem Ghalamfarsa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma�cells via the SMAD2/3 signalling pathway

(2018) Zhengzheng Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of neuropilin-1 is linked to glioma associated microglia and macrophages and correlates with unfavorable prognosis in high grade gliomas

(2018) Michael D. Caponegro et al.   Oncotarget

CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma

(2018) Francesca Lepore et al.   Frontiers in Immunology

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

(2018) Zhi-Fa Wen et al.   Journal for ImmunoTherapy of Cancer

Glioblastoma: Microenvironment and Niche Concept

(2018) Davide Schiffer et al.   Cancers

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies

(2017) Changbin Zhu et al.   NEURO-ONCOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype

(2017) M. D. Sørensen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Lomustine and Bevacizumab in Progressive Glioblastoma

(2017) Wolfgang Wick et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma

(2017) B Holmes et al.   ONCOGENE

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy

(2017) B A Castro et al.   ONCOGENE

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

(2017) D Yan et al.   ONCOGENE

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

(2017) Andrew S. Venteicher et al.   SCIENCE

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

(2017) Yu Shi et al.   Nature Communications

Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells

(2017) Xing Guo et al.   Oncotarget

Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy

(2017) Huaiyang Zhu et al.   Oncotarget

M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastoma

(2017) Marine M. Leblond et al.   Oncotarget

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth

(2017) B. R. Achyut et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples

(2016) Frank Szulzewsky et al.   GLIA

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model

(2016) Nadja Osterberg et al.   NEURO-ONCOLOGY

Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis

(2016) Ying Wang et al.   ONCOLOGY REPORTS

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rescuing defective tumor-infiltrating T-cell proliferation in glioblastoma patients

(2016) Song Han et al.   Oncology Letters

IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma

(2016) Ling Qi et al.   Oncotarget

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

(2016) Xiaofan Guo et al.   Oncotarget

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

(2016) Michael Zhang et al.   PLoS One

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

(2015) Jeroen de Vrij et al.   INTERNATIONAL JOURNAL OF CANCER

Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis

(2015) Mamatha Bangalore Nijaguna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells

(2014) Annett Müller et al.   INTERNATIONAL JOURNAL OF CANCER

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia

(2014) KIRSTEN HATTERMANN et al.   ONCOLOGY REPORTS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study

(2014) Irene Brana et al.   Targeted Oncology

GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis

(2013) Min-Chi Ku et al.   ACTA NEUROPATHOLOGICA

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers

(2013) M. Prosniak et al.   CLINICAL CANCER RESEARCH

Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages

(2013) O. Bloch et al.   CLINICAL CANCER RESEARCH

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of direct macrophage - Tumor cell interaction on progression of human glioma

(2012) Yoshihiro Komohara et al.   CANCER SCIENCE

Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer

(2012) S. Adams et al.   CLINICAL CANCER RESEARCH

Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression

(2012) Weining Yang et al.   FEBS LETTERS

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

Unknown

(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme

(2011) Wei Yan et al.   BRAIN RESEARCH

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

(2011) Takami Sato et al.   IMMUNOLOGIC RESEARCH

Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas

(2011) Xiao-bing Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells

(2011) A.C.C. da Fonseca et al.   NEUROSCIENCE

Glioblastoma Stem-Like Cells—Biology and Therapeutic Implications

(2011) Demirkan B. Gürsel et al.   Cancers

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs)

(2010) Janka Held-Feindt et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1

(2010) Li   ONCOLOGY REPORTS

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA