Article
Chemistry, Multidisciplinary
Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding, Wenhu Zhou
Summary: This review summarizes the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. The origin, polarization, and biological functions of macrophages are introduced. The disorder of macrophages in different chronic diseases is reviewed, and the pathological contributions of macrophages in representative diseases are discussed in detail. Strategies to regulate macrophages for disease immunotherapy, with a focus on bio-functional nanomaterials, are summarized. Methods for macrophage-targeting delivery nanosystems are discussed. Finally, the potential clinical translation and the development of novel macrophage-targeting nanomedicine for precise, effective, and biosafe therapy are speculated.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Chao Wan, Yajie Sun, Yan Hu, Jing Huang, Lisen Lu, Yanan Gao, Huaduan Zi, Qianyuan He, Jinfeng Sun, Jonathan F. Lovell, Kunyu Yang, Honglin Jin
Summary: A therapeutic peptide hydrogel developed in this study effectively kills tumor cells, reshapes the tumor microenvironment, and enhances the efficacy of immune checkpoint blockade therapy, leading to prolonged survival.
Article
Multidisciplinary Sciences
Fangfang Lv, Huifang Liu, Gaoqian Zhao, Erman Zhao, Hongyu Yan, Ruijun Che, Xinjian Yang, Xiaohan Zhou, Jinchao Zhang, Xing-Jie Liang, Zhenhua Li
Summary: Tumor immunotherapy is hindered by the immunosuppressive tumor microenvironment, but using exosomal vaccine derived from M1-type macrophages shows promise in enhancing the efficacy of cancer vaccine therapy.
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Rui Liu, Chongyin Han, Jiaqi Hu, Baowen Zhang, Wei Luo, Fei Ling
Summary: This study identified the impact of apoptosis on TAM polarization and immunotherapy response in CRC patients with different MMR statuses. It was found that pMMR CRC tumor tissues had a higher infiltration rate of M2-like TAM subpopulation, and apoptosis of M2c-like TAMs reduces their infiltration in tumors and contributes to a favorable immunotherapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Jinggong Liu, Wenying Li, Yongpeng Lin, Yongjun Peng, Meixiao Zhan, Haoqiang Lai, Yanzhou Chang, Yongjin Li, Ka-hing Wong, Bolai Chen, Tianfeng Chen
Summary: A dual-targeted nanotherapeutics (MP3/ACPP/AE105@NPs) with uPAR targeting and tumor microenvironment-responsive ability was developed, which improved the therapeutic efficacy and reduced toxic side effects in the treatment of breast cancer. This nanotherapeutics also stimulated immunotherapeutic response, activating cytotoxic T cells, enhancing dendritic cells maturation, and inhibiting the proliferation of tumor-associated M2 macrophages.
NPG ASIA MATERIALS
(2023)
Article
Engineering, Biomedical
Khaga R. Neupane, Geraldine S. Ramon, Brock Harvey, Byeong Chun, Surya P. Aryal, Abdullah A. Masud, J. Robert McCorkle, Jill M. Kolesar, Peter M. Kekenes-Huskey, Christopher I. Richards
Summary: Tumor-associated macrophages in the tumor microenvironment can switch from a pro-tumoral M2-like phenotype to an anti-tumoral M1-like phenotype. Programmed nanovesicles, engineered from cellular membranes with specific properties, can be used to modulate immune cell polarization and enhance immune cell reprogramming toward a proinflammatory phenotype.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Jiatong Zhang, Jingwen Cui, Jiafeng Gao, Di Zhang, Degui Lin, Jiahao Lin
Summary: Based on the experimental results, it was found that plantain polysaccharide (PLP) extracted from Plantago asiatica has the ability to polarize macrophages and inhibit the growth of breast tumors by promoting immune system function. The results showed that PLP could indirectly inhibit the migration of breast tumor cells by enhancing macrophages' phagocytosis and release of reactive oxygen species (ROS). Additionally, PLP could also promote the accumulation of macrophages and T cells in the spleen and lymph node, effectively inhibiting the growth of breast tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Summary: Integration of mathematical modeling, ecological analyses, and neoantigen prediction suggests that recruitment of immunosuppressive cells is crucial for the transformation from adenoma to carcinoma in colorectal cancer. The dynamics of tumor initiation remain unknown, but the interaction between neoplastic cells and the immune system is believed to play a critical role in this process.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Lu Shi, Hongchen Gu
Summary: Despite the great progress in immunotherapy, the efficacy in treating solid tumors has not met expectations, largely due to the immune-suppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play crucial roles in this environment, and research focuses on repolarizing them from pro-tumor to anti-tumor phenotypes. Nanotechnology offers significant opportunities for targeting and modulating TAM polarization to improve cancer immunotherapy outcomes.
Article
Chemistry, Physical
Siyuan Chen, Furong Qin, Manni Wang, Yuquan Wei, Zhiyong Qian, Xiawei Wei
Summary: The tumor microenvironment is crucial for tumorigenesis, metastasis, and drug resistance. Tumor-associated macrophages (TAMs) play a key role in creating a favorable environment for cancer cells, and nanoparticle-based drug delivery systems offer new approaches for targeting TAMs in cancer therapy. Strategies targeting TAMs with nanoparticles include blocking recruitment, promoting transformation, and diminishing existing TAMs to improve cancer treatment efficiency.
Article
Oncology
Camila Sales Nascimento, Naiara Clemente Tavares, Izabella Cristina Andrade Batista, Monica Maria Magalhaes Caetano, Eneida Santos de Oliveira, Stella Garcia Colombarolli, Anna Carolina Pinheiro Lage, Rodrigo Correa-Oliveira, erica Alessandra Rocha Alves, Celso Pinto de Melo, Carlos Eduardo Calzavara-Silva
Summary: This study found that Pani/y-Fe2O3 nanoparticles can promote polarization of M2 macrophages into M1 macrophages in breast cancer cell lines MCF-7 and MDA-MB-231, and have antitumor effects on cancer cells.
CANCER NANOTECHNOLOGY
(2023)
Review
Oncology
Yihan Sun, Genyi Jiang, Qianhua Wu, Lei Ye, Bilan Li
Summary: Tumor-associated macrophages (TAMs) in endometrial cancer (EC) play a significant role in promoting tumor development and metastasis through interactions with the tumor microenvironment, and may serve as a potential target for EC immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Baicheng Wei, Jingmei Pan, Ruiting Yuan, Binfen Shao, Yi Wang, Xing Guo, Shaobing Zhou
Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Instruments & Instrumentation
Anujan Ramesh, Vaishali Malik, Hayat Anu Ranjani, Harriet Smith, Ashish A. Kulkarni
Summary: Immune checkpoint inhibitors have revolutionized cancer immunotherapy, with macrophages playing a significant role in the tumor microenvironment. However, challenges exist in modulating macrophage functions to initiate an anti-tumor response.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Engineering, Biomedical
Anujan Ramesh, Vaishali Malik, Anthony Brouillard, Ashish Kulkarni
Summary: Tumor-associated macrophages (TAMs) can be reprogrammed metabolically from a pro-tumorigenic M2 phenotype to an antitumorigenic M1 phenotype. Recent developments have shown that distinct metabolic signatures accompany macrophages based on their polarization states. In this study, supramolecular nanoparticle system was used to deliver drugs and effectively rewired macrophage metabolism, leading to reduced tumor growth.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Chemistry, Multidisciplinary
Dipika Nandi, James Forster, Anujan Ramesh, Anh Nguyen, Hariharan Bharadwaj, Ashish Kulkarni
Summary: Inflammasome activation is associated with inflammatory diseases, but current methods have limited understanding of its kinetics and early detection of treatment efficacy. Researchers developed lipid-based nanoparticles, including a reporter nanoparticle and a theranostic nanoparticle, to monitor inflammasome activation and track treatment efficacy. The biocompatible platform enhanced probe circulation and provided in vitro and in vivo monitoring. By delivering an inflammasome-inhibiting drug with the reporter probe, real-time tracking of treatment efficacy was achieved. These findings establish novel nanotools for non-invasive evaluation of inflammasome-targeted immunotherapy.
Review
Chemistry, Physical
Anh Nguyen, Sahana Kumar, Ashish A. Kulkarni
Summary: Despite advancements in cancer immunotherapy, the heterogeneity in tumor response poses obstacles to successful treatments and accurate prognosis. Existing imaging techniques have limitations in early assessment of immune response. Engineered nanomaterials play a significant role in overcoming these challenges by improving drug delivery and dynamic imaging techniques.
Article
Chemistry, Multidisciplinary
Anujan Ramesh, Nilesh Deshpande, Vaishali Malik, Anh Nguyen, Mehak Malhotra, Maharshi Debnath, Anthony Brouillard, Ashish Kulkarni
Summary: Conventional diagnostic techniques lack sensitivity and specificity for early detection of inflammatory diseases. Detection of macrophage phenotypes can predict the prognosis of various diseases. Activatable nanoreporters have been engineered to detect M1 and M2 macrophage markers in real-time, enabling early detection of breast cancer and monitoring of inflammatory responses and wound healing in muscle injury models.
Review
Pharmacology & Pharmacy
Allison Boboltz, Sahana Kumar, Gregg A. Duncan
Summary: Asthma is a chronic lung disease with diverse pathobiological subtypes, leading to variable responses to anti-inflammatory therapies. Patient-specific treatments and effective inhalation formulations are needed. The review discusses disease progression, genetic modifiers, limitations of current treatments, and new approaches such as monoclonal antibody delivery, mucolytic therapy, and gene therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemical Research Methods
Maharshi Debnath, James Forster, Anujan Ramesh, Ashish Kulkarni
Summary: This study investigates the interaction between lipid nanoparticles (LNPs) and serum proteins, and how it affects immune responses and cellular uptake. The presence of a protein corona on LNPs reduces inflammasome activation and cellular uptake in macrophages. The lipid formulation of LNPs plays a critical role in determining their endocytic pathways.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Dipika Nandi, James Forster III, Anujan Ramesh, Anh Nguyen, Hariharan Bharadwaj, Ashish Kulkarni
Summary: This study developed a liposomal nanoreporter platform for the spatiotemporal delivery of imaging probe and inhibitor, enabling the monitoring and regulation of inflammasome activation. It exhibited the ability to detect and reduce inflammasome activation in vitro and in vivo, and alleviated inflammation. This novel tool has high potential for the real-time monitoring and treatment of inflammasome-mediated diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
James Forster, Dipika Nandi, Ashish Kulkarni
Summary: In recent years, significant progress has been made in the engineering of mRNA lipid nanoparticle vaccines, but there is still limited understanding of their immunogenicity. A design-driven approach is needed to determine the biophysical characteristics that drive nanoparticle immunogenicity. This study investigated the activation of NLRP3 inflammasomes by different lipid compositions in mRNA lipid nanoparticles and found that specific combinations of lipid types significantly influenced their activation.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Vaishali Malik, Anujan Ramesh, Ashish A. Kulkarni
Summary: The engineered nanoparticle can efficiently repolarize M2 macrophages to M1 phenotype and simultaneously block CD47-SIRPa interactions, enhancing the efficacy of macrophage immunotherapy.
ADVANCED THERAPEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Anujan Ramesh, Anthony Brouillard, Ashish Kulkarni
Summary: Tumor-associated macrophages play critical roles in tumor progression and can switch their phenotype and function, making them ideal therapeutic targets. Recent efforts in designing nanotherapeutics for macrophage immunotherapy offer new avenues for cancer immunotherapy by repolarizing tumor-associated macrophages.
ACS APPLIED BIO MATERIALS
(2021)
