Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell–specific chemokine recruitment of T cells and microglia

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

(2018) Annekathrin Reinhardt et al.   ACTA NEUROPATHOLOGICA

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

Correlation and clinical significance of LC3, CD68+ microglia, CD4+ T lymphocytes, and CD8+ T lymphocytes in gliomas

(2018) Weiguo Zhang et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Athymic mice reveal a requirement for T-cell–microglia interactions in establishing a microenvironment supportive ofNf1low-grade glioma growth

(2018) Yuan Pan et al.   GENES & DEVELOPMENT

Alternative lengthening of telomeres, ATRX loss and h3-k27m mutations in histologically defined pilocytic astrocytoma with anaplasia

(2018) Fausto J. Rodriguez et al.   BRAIN PATHOLOGY

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Optic Pathway Gliomas in Neurofibromatosis Type 1

(2017) Cynthia J. Campen et al.   JOURNAL OF CHILD NEUROLOGY

EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

(2017) Yatao Yin et al.   Journal of Neuroinflammation

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature

(2017) Yuan Pan et al.   Oncotarget

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation

(2017) Anne C. Solga et al.   Oncotarget

NF1germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1

(2016) Joseph A. Toonen et al.   HUMAN MOLECULAR GENETICS

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation

(2016) Cordelia Orillac et al.   Acta Neuropathologica Communications

KIAA1549

(2015) Aline Paixão Becker et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

(2015) Xi Feng et al.   Oncotarget

Mouse Low-Grade Gliomas Contain Cancer Stem Cells with Unique Molecular and Functional Properties

(2015) Yi-Hsien Chen et al.   Cell Reports

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

(2015) Amanda D Yzaguirre et al.   eLife

RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth

(2015) Anne C. Solga et al.   NEOPLASIA

Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma

(2014) S Han et al.   BRITISH JOURNAL OF CANCER

The challenge of intratumour heterogeneity in precision medicine

(2014) J. Seoane et al.   JOURNAL OF INTERNAL MEDICINE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The impact of coexisting genetic mutations on murine optic glioma biology

(2014) Aparna Kaul et al.   NEURO-ONCOLOGY

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

(2014) Feng Hu et al.   NEURO-ONCOLOGY

Pilocytic Astrocytoma

(2013) Zsila Sadighi et al.   JOURNAL OF CHILD NEUROLOGY

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

(2013) David T W Jones et al.   NATURE GENETICS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion

(2013) K. Vinnakota et al.   NEURO-ONCOLOGY

Immunological Genome Project and systems immunology

(2013) Tal Shay et al.   TRENDS IN IMMUNOLOGY

Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation

(2012) Winnie W. Pong et al.   ANNALS OF NEUROLOGY

BRAFDuplications and MAPK Pathway Activation Are Frequent in Gliomas of the Optic Nerve Proper

(2012) Fausto J. Rodriguez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas

(2011) K. Jacob et al.   CLINICAL CANCER RESEARCH

BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model

(2011) E. H. Raabe et al.   CLINICAL CANCER RESEARCH

Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology

(2011) Isaac Yang et al.   JOURNAL OF NEUROSURGERY

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma

(2008) B. Hegedus et al.   CANCER RESEARCH

Tandem Duplication Producing a Novel OncogenicBRAFFusion Gene Defines the Majority of Pilocytic Astrocytomas

(2008) David T.W. Jones et al.   CANCER RESEARCH