Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

(2018) Laura M. Taylor et al.   Molecular Neurodegeneration

Amyloid-beta Degradation and Neuroprotection of Dauricine Mediated by Unfolded Protein Response in a Caenorhabditis elegans model of Alzheimer’s disease

(2018) Zhijun Pu et al.   NEUROSCIENCE

Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope

(2018) Adrian B. Mehrtash et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

(2017) Jasmin Schulz et al.   JOURNAL OF CELL SCIENCE

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Regulation of Memory Formation by the Transcription Factor XBP1

(2016) Gabriela Martínez et al.   Cell Reports

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

(2014) Nicole F. Liachko et al.   PLoS Genetics

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Polymorphism −116C/G of Human X-box-Binding Protein 1 Promoter is Associated with Risk of Alzheimer's Disease

(2013) Sheng-Yuan Liu et al.   CNS Neuroscience & Therapeutics

Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease

(2013) Sven Reinhardt et al.   FASEB JOURNAL

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Antibody Staining in C. Elegans Using "Freeze-Cracking"

(2013) Janet S. Duerr   Jove-Journal of Visualized Experiments

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

(2013) Lauren D Stutzbach et al.   Acta Neuropathologica Communications

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

(2011) Günter U Höglinger et al.   NATURE GENETICS

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

(2010) Carin A. Loewen et al.   PLoS One

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the α2δ subunit UNC-36

(2009) Yasunori Saheki et al.   NATURE NEUROSCIENCE

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE