Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

(2021) Nora Bengoa-Vergniory et al.   Acta Neuropathologica Communications

iREAD: a tool for intron retention detection from RNA-seq data

(2020) Hong-Dong Li et al.   BMC GENOMICS

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

(2020) Mauro Montalbano et al.   Nature Communications

SON and SRRM2 are essential for nuclear speckle formation

(2020) İbrahim Avşar Ilik et al.   eLife

Tau Modulates VGluT1 Expression

(2019) Giacomo Siano et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

(2019) Atsushi Aoyagi et al.   Science Translational Medicine

Improved TGIRT-seq methods for comprehensive transcriptome profiling with decreased adapter dimer formation and bias correction

(2019) Hengyi Xu et al.   Scientific Reports

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs

(2019) James M. Burke et al.   MOLECULAR CELL

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

(2019) Jeanna M. Wheeler et al.   Science Translational Medicine

Dysregulation of RNA Splicing in Tauopathies

(2019) Daniel J. Apicco et al.   Cell Reports

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

(2018) Guadalupe Sepulveda et al.   eLife

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

(2018) Towfique Raj et al.   NATURE GENETICS

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology

(2018) Hikari Tanaka et al.   MOLECULAR PSYCHIATRY

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

(2018) Giorgio Ulrich et al.   Scientific Reports

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

Nuclear speckles: molecular organization, biological function and role in disease

(2017) Lukasz Galganski et al.   NUCLEIC ACIDS RESEARCH

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice

(2017) Noah R. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic production of single-molecule FISH and RNA capture probes

(2017) Imre Gaspar et al.   RNA

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Tau mis-splicing in the pathogenesis of neurodegenerative disorders

(2016) Sun Ah Park et al.   BMB Reports

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

(2016) Jonathan L. Schmid-Burgk et al.   Nature Communications

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

A new view of transcriptome complexity and regulation through the lens of local splicing variations

(2016) Jorge Vaquero-Garcia et al.   eLife

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Coordinated Dynamics of RNA Splicing Speckles in the Nucleus

(2015) Qiao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

(2015) Marie Violet et al.   NEUROBIOLOGY OF DISEASE

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Transcriptional landscape of repetitive elements in normal and cancer human cells

(2014) Steven W Criscione et al.   BMC GENOMICS

Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease

(2014) Chadwick M. Hales et al.   BRAIN PATHOLOGY

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

(2014) Chadwick M Hales et al.   Molecular Neurodegeneration

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus

(2013) Chang Liu et al.   PLoS One

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

(2012) Ismael Santa-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

(2012) Clotilde Lagier-Tourenne et al.   NATURE NEUROSCIENCE

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MSUT2 is a determinant of susceptibility to tau neurotoxicity

(2011) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Ensembl BioMarts: a hub for data retrieval across taxonomic space

(2011) R. J. Kinsella et al.   Database-The Journal of Biological Databases and Curation

Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin

(2010) Magdalena Maj et al.   JOURNAL OF ENDOCRINOLOGY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Next Generation Sequencing of miRNAs – Strategies, Resources and Methods

(2010) Susanne Motameny et al.   Genes

Pericentrin in cellular function and disease

(2009) Benedicte Delaval et al.   JOURNAL OF CELL BIOLOGY

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome

(2009) R. J. Grainger et al.   RNA

Binding of ATP to UAP56 is necessary for mRNA export

(2008) K. P. Kota et al.   JOURNAL OF CELL SCIENCE