Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease

Azure C Targets and Modulates Toxic Tau Oligomers

(2018) Filippa Lo Cascio et al.   ACS Chemical Neuroscience

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

(2018) Isaac Bishof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

(2018) Laura M. Taylor et al.   Molecular Neurodegeneration

TDP-43 and FUS en route from the nucleus to the cytoplasm

(2017) Helena Ederle et al.   FEBS LETTERS

RNA-binding proteins in neurodegeneration: mechanisms in aggregate

(2017) Erin G. Conlon et al.   GENES & DEVELOPMENT

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders

(2017) Brandon Maziuk et al.   Frontiers in Molecular Neuroscience

Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis

(2017) Rachel H. Tan et al.   Acta Neuropathologica Communications

De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies

(2017) Kana Mitsuhashi et al.   Scientific Reports

Distinguishing aggregate formation and aggregate clearance using cell-based assays

(2016) Evelien Eenjes et al.   JOURNAL OF CELL SCIENCE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

(2016) James Taggart et al.   Nature Communications

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina

(2016) Daniel Murphy et al.   PLoS Genetics

RNA-binding proteins implicated in neurodegenerative diseases

(2016) Mark R Cookson   Wiley Interdisciplinary Reviews-RNA

Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

(2016) Cecilia A. Brunello et al.   Scientific Reports

Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules

(2015) Virgil Muresan et al.   Neurodegenerative Diseases

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

(2015) Cristian A Lasagna-Reeves et al.   eLife

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

(2015) Cristian A Lasagna-Reeves et al.   eLife

Forgetting Is Regulated via Musashi-Mediated Translational Control of the Arp2/3 Complex

(2014) Nils Hadziselimovic et al.   CELL

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

(2014) Marcos J. Guerrero-Muñoz et al.   NEUROBIOLOGY OF DISEASE

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

(2014) Nicole F. Liachko et al.   PLoS Genetics

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

(2014) Yarden Katz et al.   eLife

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

(2013) J. Janssens et al.   HUMAN MOLECULAR GENETICS

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice

(2011) L. de Andres-Aguayo et al.   BLOOD

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

3′-Untranslated region ofdoublecortinmRNA is a binding target of the Musashi1 RNA-binding protein

(2009) Kenichi Horisawa et al.   FEBS LETTERS

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and regulation of the mammalian Musashi mRNA translational regulator

(2008) Angus M. MacNicol et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP

(2008) Hironori Kawahara et al.   JOURNAL OF CELL BIOLOGY

Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt

(2008) Jun Kaneko et al.   NEUROSCIENCE LETTERS