Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Equilibrative Nucleoside Transporters-1 Inhibitors Act as Anti-epileptic Agents by Inhibiting Glutamatergic Transmission

(2021) Shih-Yin Ho et al.   Frontiers in Neuroscience

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

(2020) Jin Zheng et al.   Acta Neuropathologica Communications

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Maternal erythrocyte ENT1–mediated AMPK activation counteracts placental hypoxia and supports fetal growth

(2020) Seisuke Sayama et al.   JCI Insight

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy

(2020) Victoria Gomez-Murcia et al.   NEUROBIOLOGY OF AGING

Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons

(2020) Wanling Peng et al.   SCIENCE

Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process

(2019) Manon Domise et al.   Cell Death & Disease

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

(2019) Kevin Carvalho et al.   BRAIN

Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology

(2018) Patricia Alonso-Andrés et al.   BRAIN PATHOLOGY

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

(2018) Chia-Chia Lee et al.   MOLECULAR NEUROBIOLOGY

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

(2018) Mariana Temido-Ferreira et al.   MOLECULAR PSYCHIATRY

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

(2018) António C. Silva et al.   NEUROBIOLOGY OF DISEASE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2018) Emilie Faivre et al.   Frontiers in Molecular Neuroscience

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Instant Clue: A Software Suite for Interactive Data Visualization and Analysis

(2018) Hendrik Nolte et al.   Scientific Reports

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

(2018) Snehajyoti Chatterjee et al.   EMBO Molecular Medicine

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

(2018) Hong Wang et al.   Molecular Neurodegeneration

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model

(2017) E Lauretti et al.   Translational Psychiatry

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey

(2016) J. D. Young   BIOCHEMICAL SOCIETY TRANSACTIONS

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

TheMAPTgene is differentially methylated in the progressive supranuclear palsy brain

(2016) Vincent Huin et al.   MOVEMENT DISORDERS

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning

(2016) Ching-Pang Chang et al.   Scientific Reports

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

(2016) Manon Domise et al.   Scientific Reports

Mitochondrial ATP synthase activity is impaired by suppressedO-GlcNAcylation in Alzheimer's disease

(2015) Moon-Yong Cha et al.   HUMAN MOLECULAR GENETICS

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid  

(2014) T. Ma et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells

(2013) Lorena Medina-Pulido et al.   BIOCHEMICAL JOURNAL

Hypoglycemia Induces Tau Hyperphosphorylation

(2013) Chu-Wan Lee et al.   Current Alzheimer Research

Tau Pathology is Present In Vivo and Develops In Vitro in Sensory Neurons from Human P301S Tau Transgenic Mice: A System for Screening Drugs against Tauopathies

(2013) M. Mellone et al.   JOURNAL OF NEUROSCIENCE

Reactive astrocytes secrete lcn2 to promote neuron death

(2013) F. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Striatal Adenosine Signaling Regulates EAAT2 and Astrocytic AQP4 Expression and Alcohol Drinking in Mice

(2012) Moonnoh R Lee et al.   NEUROPSYCHOPHARMACOLOGY

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

An emerging role for adenosine and its receptors in bone homeostasis

(2012) Jack Ham et al.   Frontiers in Endocrinology

Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier

(2011) A. J. Carman et al.   JOURNAL OF NEUROSCIENCE

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

(2010) Ann Van der Jeugd et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Adenosine, energy metabolism and sleep homeostasis

(2010) Tarja Porkka-Heiskanen et al.   SLEEP MEDICINE REVIEWS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH