Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/− mouse model of ALSP, which can be rescued via CSF1R inhibitors

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

(2020) Ellis Chika Onwordi et al.   Nature Communications

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

(2020) Violeta Chitu et al.   Cell Reports

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

(2020) Liam Kempthorne et al.   Acta Neuropathologica Communications

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

(2020) Phi T. Nguyen et al.   CELL

To Kill a Microglia: A Case for CSF1R Inhibitors

(2020) Kim N. Green et al.   TRENDS IN IMMUNOLOGY

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

(2020) Joshua D. Crapser et al.   EBioMedicine

Microglial reduction of colony stimulating factor‐1 receptor expression is sufficient to confer adult onset leukodystrophy

(2020) Fabrizio Biundo et al.   GLIA

CSF1R signaling is a regulator of pathogenesis in progressive MS

(2020) Nellwyn Hagan et al.   Cell Death & Disease

In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay

(2019) Daniel Schulz et al.   Scientific Reports

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

(2019) Nynke Oosterhof et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phenotypic impacts of CSF1R deficiencies in humans and model organisms

(2019) David A. Hume et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

(2019) James W. Fawcett et al.   NATURE REVIEWS NEUROSCIENCE

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

(2019) Renzo Mancuso et al.   BRAIN

Factors predictive of the presence of a CSF1R mutation in patients with leukoencephalopathy

(2019) Yasufumi Kondo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses

(2019) Christine Gottschling et al.   Scientific Reports

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

(2019) Joshua D Crapser et al.   BRAIN

Clinicopathologic characterization and abnormal autophagy of CSF1R-related leukoencephalopathy

(2019) Wo-Tu Tian et al.   Translational Neurodegeneration

Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

(2018) Yeon-Joo Jung et al.   Biomolecules & Therapeutics

Partial loss of function of colony-stimulating factor 1 receptor in a patient with white matter abnormalities

(2018) T. Konno et al.   EUROPEAN JOURNAL OF NEUROLOGY

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)

(2018) Scott J. Adams et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

(2018) Clare Pridans et al.   JOURNAL OF IMMUNOLOGY

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

(2018) Nynke Oosterhof et al.   Cell Reports

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

(2017) Emilia Favuzzi et al.   NEURON

Extracellular matrix alterations in the ketamine model of schizophrenia

(2017) Gabriela Matuszko et al.   NEUROSCIENCE

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week

(2015) Maria Nikodemova et al.   JOURNAL OF NEUROIMMUNOLOGY

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held

(2015) Maren Blosa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia linked CSF1R mutation: Report of four Korean cases

(2015) Eun-Joo Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

(2015) Violeta Chitu et al.   NEUROBIOLOGY OF DISEASE

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

(2015) H Pantazopoulos et al.   Translational Psychiatry

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Enlarging the Nosological Spectrum of Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids (HDLS)

(2014) Sarah Hoffmann et al.   BRAIN PATHOLOGY

Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury

(2014) Zai-Wang Li et al.   Journal of Neuroinflammation

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

M-CSF receptor mutations in hereditary diffuse leukoencephalopathy with spheroids impair not only kinase activity but also surface expression

(2013) Masateru Hiyoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation

(2013) Clarissa L Waites et al.   EMBO JOURNAL

Chondroitin Sulfate Proteoglycan Tenascin-R Regulates Glutamate Uptake by Adult Brain Astrocytes

(2013) Hiroaki Okuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

(2013) M. Geissler et al.   JOURNAL OF NEUROSCIENCE

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

CSF1R mutations link POLD and HDLS as a single disease entity

(2013) A. M. Nicholson et al.   NEUROLOGY

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS

(2013) T. Konno et al.   NEUROLOGY

Investigations into the involvement of NMDA mechanisms in recognition memory

(2013) E. Clea Warburton et al.   NEUROPHARMACOLOGY

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Perineuronal nets protect fast-spiking interneurons against oxidative stress

(2013) J.-H. Cabungcal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis

(2013) E P Azevedo et al.   Cell Death & Disease

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function

(2013) Clare Pridans et al.   Scientific Reports

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

(2012) Sayan Nandi et al.   DEVELOPMENTAL BIOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Molecular signals of plasticity at the tetrapartite synapse

(2011) Alexander Dityatev et al.   CURRENT OPINION IN NEUROBIOLOGY

Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury

(2011) Ellen M. Andrews et al.   EXPERIMENTAL NEUROLOGY

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

The role of hippocampal subregions in memory for stimulus associations

(2010) Rosamund F. Langston et al.   BEHAVIOURAL BRAIN RESEARCH

Perineuronal net formation and structure in aggrecan knockout mice

(2010) K.A. Giamanco et al.   NEUROSCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE