Phenotypic impacts of CSF1R deficiencies in humans and model organisms

IL-34–Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice

(2019) Yukihiro Wada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation

(2019) Long Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

(2019) Nynke Oosterhof et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

(2019) Sarah R. Anderson et al.   Cell Reports

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats

(2018) Clare Pridans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice

(2018) Georgios Vassilakos et al.   FASEB JOURNAL

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)

(2018) Scott J. Adams et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Altered compensatory cytokine signaling underlies the discrepancy betweenFlt3–/–andFlt3l–/–mice

(2018) Vivek Durai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System

(2018) Catherine A. Hawley et al.   JOURNAL OF IMMUNOLOGY

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease

(2018) Jennifer Sjaarda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

(2018) Krista J. Spiller et al.   NATURE NEUROSCIENCE

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3

(2018) Celeste Sassi et al.   NEUROBIOLOGY OF AGING

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

(2018) Anuj Sehgal et al.   Nature Communications

Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus

(2018) Clare Pridans et al.   JOURNAL OF IMMUNOLOGY

Identification and functional characterization of novel mutations including frameshift mutation in exon 4 of CSF1R in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

(2018) Takeshi Miura et al.   JOURNAL OF NEUROLOGY

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

(2018) Nynke Oosterhof et al.   Cell Reports

CSF1R-related leukoencephalopathy

(2018) Takuya Konno et al.   NEUROLOGY

The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages

(2018) David A. Hume et al.   TRENDS IN IMMUNOLOGY

Genome Toxicity and Impaired Stem Cell Function after Conditional Activation of CreERT2 in the Intestine

(2018) Natacha Bohin et al.   Stem Cell Reports

ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages

(2018) Lindsey A. Waddell et al.   Frontiers in Immunology

Autozygosity reveals recessive mutations and novel mechanisms in dominant genes: implications in variant interpretation

(2017) Dorota Monies et al.   GENETICS IN MEDICINE

Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data

(2017) Kim M. Summers et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

(2017) Sarah M Carpanini et al.   NEUROGENETICS

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

(2017) Emily L. Clark et al.   PLoS Genetics

The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates

(2017) David A. Hume et al.   Scientific Reports

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

(2017) Lena Batoon et al.   BIOMATERIALS

Colony stimulating factors (CSFs): Complex roles in atherosclerosis

(2017) Aarushi Singhal et al.   CYTOKINE

Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs

(2016) Kristin A. Sauter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

(2016) Mari Tada et al.   ANNALS OF NEUROLOGY

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated withCSF1Rmutation

(2016) T. Konno et al.   EUROPEAN JOURNAL OF NEUROLOGY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage

(2016) Minshu Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ACsf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep

(2016) Clare Pridans et al.   JOURNAL OF IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics

(2016) Carmen Stabile et al.   NEUROLOGICAL SCIENCES

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Role of IGF Binding Proteins in Regulating Metabolism

(2016) David R. Clemmons   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation

(2015) T. P. Hofer et al.   BLOOD

The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor

(2015) Valerie Garceau et al.   BMC BIOLOGY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages

(2015) Alasdair W. Jubb et al.   JOURNAL OF IMMUNOLOGY

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury

(2015) Yinqiu Wang et al.   KIDNEY INTERNATIONAL

FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors

(2015) C C Smith et al.   LEUKEMIA

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization

(2015) Joanne Tonkin et al.   MOLECULAR THERAPY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

(2015) Violeta Chitu et al.   NEUROBIOLOGY OF DISEASE

Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses

(2015) Hye Rim Chang et al.   Obesity

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

(2015) Erik Arner et al.   SCIENCE

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

(2015) C. C. Smith et al.   Cancer Discovery

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

(2014) T. S. Kim et al.   CLINICAL CANCER RESEARCH

Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage

(2014) A. Balic et al.   DEVELOPMENT

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

(2014) K. A. Sauter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor

(2014) Deborah J Gow et al.   MOLECULAR THERAPY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

A promoter-level mammalian expression atlas

(2014)   NATURE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration

(2014) Kristin A. Sauter et al.   PLoS One

Homeostasis in the mononuclear phagocyte system

(2014) Stephen J. Jenkins et al.   TRENDS IN IMMUNOLOGY

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment

(2013) Tamasin N Doig et al.   BMC GENOMICS

The pro-Forms of Insulin-Like Growth Factor I (IGF-I) Are Predominant in Skeletal Muscle and Alter IGF-I Receptor Activation

(2013) Julia Durzyńska et al.   ENDOCRINOLOGY

Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34

(2013) Sayan Nandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response

(2013) Duy Huynh et al.   PLoS One

Human IL-34 and CSF-1 Establish Structurally Similar Extracellular Assemblies with Their Common Hematopoietic Receptor

(2013) Jan Felix et al.   STRUCTURE

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function

(2013) Clare Pridans et al.   Scientific Reports

Genetic Analysis of Inherited Leukodystrophies

(2013) Rita Guerreiro et al.   JAMA Neurology

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

(2012) Sayan Nandi et al.   DEVELOPMENTAL BIOLOGY

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pig Bone Marrow-Derived Macrophages Resemble Human Macrophages in Their Response to Bacterial Lipopolysaccharide

(2012) R. Kapetanovic et al.   JOURNAL OF IMMUNOLOGY

Identification of IL-34 in teleost fish: Differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor

(2012) Tiehui Wang et al.   MOLECULAR IMMUNOLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Junctional Adhesion Molecule (JAM)-C Deficient C57BL/6 Mice Develop a Severe Hydrocephalus

(2012) Lena Wyss et al.   PLoS One

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CSF-1 receptor fashions the intestinal stem cell niche

(2012) Dilara Akcora et al.   Stem Cell Research

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R

(2012) Xiaolei Ma et al.   STRUCTURE

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

(2011) Maliha A. Alikhan et al.   AMERICAN JOURNAL OF PATHOLOGY

Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects

(2011) Stephen E. Harris et al.   BONE

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone

(2011) Omar M E Albagha et al.   NATURE GENETICS

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1 ), interleukin-34 (IL-34 ), and CSF-1 receptor genes and gene products

(2010) Valerie Garceau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CSF-1, IGF-1, and the control of postnatal growth and development

(2010) Deborah J. Gow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

Septoclast Deficiency Accompanies Postnatal Growth Plate Chondrodysplasia in the Toothless (tl) Osteopetrotic, Colony-Stimulating Factor-1 (CSF-1)-Deficient Rat and Is Partially Responsive to CSF-1 Injections

(2009) Alison Gartland et al.   AMERICAN JOURNAL OF PATHOLOGY

Colony Stimulating Factor-1 Dependence of Paneth Cell Development in the Mouse Small Intestine

(2009) Duy Huynh et al.   GASTROENTEROLOGY

CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice

(2009) Julia Menke et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development

(2008) June Goto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE