Magnetic Resonance Imaging–Guided Phase 1 Trial of Putaminal AADC Gene Therapy for Parkinson's Disease

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

(2017) Valerie Voon et al.   LANCET NEUROLOGY

Changes in Quality of Life in Parkinson's Disease: How Large Must They Be to Be Relevant?

(2017) Krisztina Horváth et al.   NEUROEPIDEMIOLOGY

Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease

(2017) Yoshihide Sehara et al.   Human Gene Therapy Clinical Development

Depletion of AADC activity in caudate nucleus and putamen of Parkinson’s disease patients; implications for ongoing AAV2-AADC gene therapy trial

(2017) Agnieszka Ciesielska et al.   PLoS One

Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies

(2015) John Forsayeth et al.   MOLECULAR THERAPY

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial

(2014) PD MED Collaborative Group   LANCET

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy

(2013) Raymond T Bartus et al.   MOLECULAR THERAPY

Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease

(2012) Gabriele Mittermeyer et al.   HUMAN GENE THERAPY

Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain

(2011) R. Mark Richardson et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale

(2010) Lisa M. Shulman et al.   ARCHIVES OF NEUROLOGY

Effects of a Dopamine Agonist on the Pharmacodynamics of Levodopa in Parkinson Disease

(2010) Matthew A. Brodsky et al.   ARCHIVES OF NEUROLOGY

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

(2010) Xiaomin Su et al.   MOLECULAR THERAPY

Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

(2010) Piotr Hadaczek et al.   MOLECULAR THERAPY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

Systematic review of levodopa dose equivalency reporting in Parkinson's disease

(2010) Claire L. Tomlinson et al.   MOVEMENT DISORDERS

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY