Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation

(2021) Yunki Lim et al.   Autophagy

Pathophysiology of sepsis-induced cardiomyopathy

(2021) Steven M. Hollenberg et al.   Nature Reviews Cardiology

UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans

(2021) Tomer Shpilka et al.   Nature Communications

Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside

(2021) Hao Zhou et al.   AGEING RESEARCH REVIEWS

At the heart of mitochondrial quality control: many roads to the top

(2021) Roberta A. Gottlieb et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mitochondrial unfolded protein response and its diverse roles in cellular stress

(2021) Ioannis Smyrnias   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial unfolded protein response: A novel pathway in metabolism and immunity

(2021) Li Zhu et al.   PHARMACOLOGICAL RESEARCH

DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis

(2020) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation

(2020) Ravi K. Adapala et al.   BASIC RESEARCH IN CARDIOLOGY

Tryptophane–kynurenine pathway in the remote ischemic conditioning mechanism

(2020) Oussama Bakhta et al.   BASIC RESEARCH IN CARDIOLOGY

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

(2020) Fang Cao et al.   BASIC RESEARCH IN CARDIOLOGY

Murine sca1/flk1-positive cells are not endothelial progenitor cells, but B2 lymphocytes

(2020) Eva Steffen et al.   BASIC RESEARCH IN CARDIOLOGY

FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction

(2020) Christine Veith et al.   BASIC RESEARCH IN CARDIOLOGY

Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury

(2020) Jin Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Pathological Roles of Mitochondrial Oxidative Stress and Mitochondrial Dynamics in Cardiac Microvascular Ischemia/Reperfusion Injury

(2020) Hao Zhou et al.   Biomolecules

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism

(2020) Ying Tan et al.   ACTA PHARMACOLOGICA SINICA

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

(2020) Jin Wang et al.   ANGIOGENESIS

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation

(2020) Timothy D. Le Cras et al.   ANGIOGENESIS

Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3

(2020) Jin Wang et al.   BIOCHEMICAL PHARMACOLOGY

Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans

(2020) Kelly H. Oh et al.   FASEB JOURNAL

Myocardial Edema and Remodeling

(2020) Francisco Vasques-Nóvoa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

(2020) Jin Wang et al.   Acta Pharmaceutica Sinica B

Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis

(2020) Dorothy E. Vatner et al.   BASIC RESEARCH IN CARDIOLOGY

The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells

(2020) Beatrice Pflüger-Müller et al.   BASIC RESEARCH IN CARDIOLOGY

NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux

(2020) You-Jun Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials

(2020) Jin Wang et al.   PHARMACOLOGICAL RESEARCH

Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension

(2020) Max-Paul Winter et al.   BASIC RESEARCH IN CARDIOLOGY

Nuclear-encoded lncRNA MALAT1 epigenetically controls metabolic reprogramming in hepatocellular carcinoma cells through the mitophagy pathway

(2020) Yijing Zhao et al.   Molecular Therapy-Nucleic Acids

Mitochondrial quality surveillance as a therapeutic target in myocardial infarction

(2020) Hang Zhu et al.   Acta Physiologica

SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

(2020) Ying Tan et al.   Molecular Therapy-Nucleic Acids

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

(2019) Dimitra Kokkinaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model

(2019) Takashi Honda et al.   BASIC RESEARCH IN CARDIOLOGY

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Preclinical septic shock research: why we need an animal ICU

(2019) Antoine Guillon et al.   Annals of Intensive Care

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

(2019) Yves T. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glucose withdrawal induces Endothelin 1 release with significant angiogenic effect from first trimester (FTM), but not term human umbilical cord perivascular cells (HUCPVC)

(2019) Peter Szaraz et al.   ANGIOGENESIS

The Challenging Diagnosis of Septic Cardiomyopathy

(2019) Filippo Sanfilippo et al.   CHEST

Extracorporeal Membrane Oxygenation for Septic Shock

(2019) Lars Falk et al.   CRITICAL CARE MEDICINE

Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function

(2019) Jiankai Zhong et al.   Redox Biology

The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis

(2019) Patrick Fournier et al.   ANGIOGENESIS

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer

(2019) Daniela Unterleuthner et al.   ANGIOGENESIS

Angiotropism, pericytic mimicry and extravascular migratory metastasis: an embryogenesis-derived program of tumor spread

(2019) Claire Lugassy et al.   ANGIOGENESIS

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk–Nox2–Drp1-mitochondrial fission pathways

(2018) Hao Zhou et al.   ANGIOGENESIS

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

(2018) Hao Zhou et al.   CELL DEATH AND DIFFERENTIATION

Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based cellular migration

(2018) Hao Zhou et al.   CELLULAR SIGNALLING

Septic Cardiomyopathy

(2018) Sarah J. Beesley et al.   CRITICAL CARE MEDICINE

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

(2018) Qinhua Jin et al.   Redox Biology

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

(2018) Hao Zhou et al.   Redox Biology

Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy

(2018) Ruibing Li et al.   Redox Biology

THE SEPTIC HEART Current Understanding of Molecular Mechanisms and Clinical Implications

(2018) Lukas Martin et al.   CHEST

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

(2017) Hao Zhou et al.   Redox Biology

Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection

(2015) Mark W Pellegrino et al.   BMC BIOLOGY