Preclinical septic shock research: why we need an animal ICU

Exploring the fate of inhaled monoclonal antibody in the lung parenchyma by microdialysis

(2019) Antoine Guillon et al.   mAbs

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

(2018) Johan Lindqvist et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sepsis-induced myocardial dysfunction

(2018) Keith R. Walley   Current Opinion in Critical Care

Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics

(2018) A. Guillon et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity

(2018) Xiqing Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of Psychosocial Stress on Subsequent Hemorrhagic Shock and Resuscitation in Male Mice

(2018) Dominik Langgartner et al.   SHOCK

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss)

(2018) Marcin F. Osuchowski et al.   SHOCK

A walk on the wild side

(2017) Dustin M. Graham   LAB ANIMAL

Myricetin attenuated LPS induced cardiac injury in vivo and in vitro

(2017) Nan Zhang et al.   PHYTOTHERAPY RESEARCH

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy

(2016) Sebastien Preau et al.   ANTIOXIDANTS & REDOX SIGNALING

Human lung ex vivo infection models

(2016) Andreas C. Hocke et al.   CELL AND TISSUE RESEARCH

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma

(2016) K. Horst et al.   Scientific Reports

Alterations in expression of elastogenic and angiogenic genes by different conditions of mechanical ventilation in newborn rat lung

(2015) Andreas A. Kroon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca2+ removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan

(2015) S. Wagner et al.   BASIC RESEARCH IN CARDIOLOGY

Beta-blocker use in severe sepsis and septic shock: a systematic review

(2015) Filippo Sanfilippo et al.   CURRENT MEDICAL RESEARCH AND OPINION

Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence

(2015) Antoine Guillon et al.   EUROPEAN RESPIRATORY JOURNAL

Critical Care Evidence—New Directions

(2015) John J. Marini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Low tidal volume ventilation ameliorates left ventricular dysfunction in mechanically ventilated rats following LPS-induced lung injury

(2015) Thomas GV Cherpanath et al.   BMC Anesthesiology

Animal models for influenza virus transmission studies: a historical perspective

(2015) Nicole M Bouvier   Current Opinion in Virology

Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma

(2015) Julia Kemmler et al.   PLoS One

Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets

(2015) Antoine Guillon et al.   PLoS One

Effects and Mechanism Analysis of Combined Infusion by Levosimendan and Vasopressin on Acute Lung Injury in Rats Septic Shock

(2014) Xuebing Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Genome modification by CRISPR/Cas9

(2014) Yuanwu Ma et al.   FEBS Journal

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abandon the Mouse Research Ship? Not Just Yet!

(2014) Marcin F. Osuchowski et al.   SHOCK

Optimal Management of the Critically Ill: Anaesthesia, Monitoring, Data Capture, and Point-of-Care Technological Practices in Ovine Models of Critical Care

(2014) Saul Chemonges et al.   Biomed Research International

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Troponin Elevation in Severe Sepsis and Septic Shock

(2013) Giora Landesberg et al.   CRITICAL CARE MEDICINE

Carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine kidney ischemia/reperfusion injury

(2013) Šárka Matějková et al.   INTENSIVE CARE MEDICINE

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruption of Calcium Homeostasis in Cardiomyocytes Underlies Cardiac Structural and Functional Changes in Severe Sepsis

(2013) Mara R. N. Celes et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship between Age/Gender-Induced Survival Changes and the Magnitude of Inflammatory Activation and Organ Dysfunction in Post-Traumatic Sepsis

(2012) Susanne Drechsler et al.   PLoS One

Type 2 Diabetes Mellitus in Mice Aggravates the Renal Impact of Hemorrhagic Shock

(2012) Virginie Dupuy et al.   SHOCK

New insights into the pathophysiology of aspiration pneumonia

(2011) A. Guillon et al.   BRITISH JOURNAL OF ANAESTHESIA

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Effects of Combined Levosimendan and Vasopressin on Pulmonary Function in Porcine Septic Shock

(2011) Muhuo Ji et al.   INFLAMMATION

Comparison of carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury

(2011) Florian Simon et al.   INTENSIVE CARE MEDICINE

Recurrent Recruitment Manoeuvres Improve Lung Mechanics and Minimize Lung Injury during Mechanical Ventilation of Healthy Mice

(2011) Lucy Kathleen Reiss et al.   PLoS One

Septic cardiomyopathy

(2011) Antoine Vieillard-Baron   Annals of Intensive Care

Protective Role of Peroxisome Proliferator–activated Receptor-β/δ in Septic Shock

(2010) Amar Kapoor et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ventricular Dilation Is Associated With Improved Cardiovascular Performance and Survival in Sepsis

(2010) Sergio L. Zanotti Cavazzoni et al.   CHEST

Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock*

(2010) Sebastian Rehberg et al.   CRITICAL CARE MEDICINE

Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats

(2010) Massimo Collino et al.   FREE RADICAL BIOLOGY AND MEDICINE

DIRECT CARDIAC EFFECTS OF DOBUTAMINE, DOPAMINE, EPINEPHRINE, AND LEVOSIMENDAN IN ISOLATED SEPTIC RAT HEARTS

(2010) York A. Zausig et al.   SHOCK

LEVOSIMENDAN INCREASES PORTAL BLOOD FLOW AND ATTENUATES INTESTINAL INTRAMUCOSAL ACIDOSIS IN EXPERIMENTAL SEPTIC SHOCK

(2010) Javier García-Septien et al.   SHOCK

Inotropic Support During Experimental Endotoxemic Shock: Part I. The Effects of Levosimendan on Splanchnic Perfusion

(2009) Doris Cunha-Goncalves et al.   ANESTHESIA AND ANALGESIA

Inotropic Support During Experimental Endotoxemic Shock: Part II. A Comparison of Levosimendan with Dobutamine

(2009) Doris Cunha-Goncalves et al.   ANESTHESIA AND ANALGESIA

Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury

(2009) Aimalohi Esechie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of levosimendan in sepsis and septic shock

(2009) Bernardo Bollen Pinto et al.   Current Opinion in Anesthesiology

Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock

(2008) Michael Fries et al.   CRITICAL CARE MEDICINE

Modeling human lung disease in animals

(2007) Lorraine B. Ware   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY