Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice

(2021) Katie A. Bretland et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

(2020) Nicolas J. Pillon et al.   Nature Communications

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

(2020) James A. Sanford et al.   CELL

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

(2020) Alana M. Horowitz et al.   SCIENCE

Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects

(2019) Jahae Kim et al.   Scientific Reports

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

(2019) Camilla Steen Jensen et al.   EXPERIMENTAL GERONTOLOGY

Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

(2019) Kexin Wang et al.   MEDIATORS OF INFLAMMATION

Metabolomic Analysis of Skeletal Muscle in Aged Mice

(2019) Ran Uchitomi et al.   Scientific Reports

Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis

(2019) Lars Karlsson et al.   Scientific Reports

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

(2019) Ceereena Ubaida-Mohien et al.   eLife

Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis

(2019) Maricela Robles-Murguia et al.   GENES & DEVELOPMENT

Stereological Investigation of the Effects of Treadmill Running Exercise on the Hippocampal Neurons in Middle-Aged APP/PS1 Transgenic Mice

(2018) Fenglei Chao et al.   JOURNAL OF ALZHEIMERS DISEASE

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review

(2018) Freddy MH Lam et al.   Journal of Physiotherapy

Associations of Gene Sequence Variation and Serum Levels of C-Reactive Protein and Interleukin-6 with Alzheimer's Disease and Dementia

(2018) Ulrika K. Eriksson et al.   JOURNAL OF ALZHEIMERS DISEASE

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Do Non-Responders to Exercise Exist—and If So, What Should We Do About Them?

(2018) Craig Pickering et al.   SPORTS MEDICINE

Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells

(2018) Hyo Youl Moon et al.   NEUROPHARMACOLOGY

Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study

(2017) Jae Seung Chang et al.   Geriatrics & Gerontology International

Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study

(2017) Barbara Fenesi et al.   JOURNAL OF ALZHEIMERS DISEASE

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

(2017) Audrey S. Dickey et al.   Science Translational Medicine

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Acute effects of concentric and eccentric exercise on glucose metabolism and interleukin-6 concentration in healthy males

(2016) Marc Philippe et al.   BIOLOGY OF SPORT

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Exercise Promotes Healthy Aging of Skeletal Muscle

(2016) Gregory D. Cartee et al.   Cell Metabolism

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

(2016) Fan Su et al.   Neuroscience Bulletin

Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

(2016) A. B. Fagundo et al.   Scientific Reports

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

(2016) M Hüttenrauch et al.   Translational Psychiatry

The Effects of Aerobic Exercise on Cognitive Function of Alzheimer’s Disease Patients

(2015) Si-Yu Yang et al.   CNS & Neurological Disorders-Drug Targets

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

(2015) Thierry Paillard et al.   Journal of Clinical Neurology

The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease

(2015) C. Phillips et al.   PHYSICAL THERAPY

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

Exercise-mimetic AICAR transiently benefits brain function

(2015) Davide Guerrieri et al.   Oncotarget

A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice

(2015) Wei Chen et al.   Scientific Reports

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

(2015) Gregory Hook et al.   Frontiers in Neurology

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2014) Laia Salvadó et al.   DIABETOLOGIA

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

(2014) I. L. Campbell et al.   JOURNAL OF NEUROSCIENCE

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice

(2014) Odochi Ohia-Nwoko et al.   Molecular Neurodegeneration

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy

(2014) Constanza J. Cortes et al.   NEURON

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia

(2013) Zhou Wu et al.   NEUROBIOLOGY OF AGING

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

(2012) Michael W. Marlatt et al.   Developmental Neurobiology

Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain

(2012) L. Sun et al.   JOURNAL OF NEUROSCIENCE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Voluntary Running and Environmental Enrichment Restores Impaired Hippocampal Neurogenesis in a Triple Transgenic Mouse Model of Alzheimers Disease

(2011) J. J. Rodriguez et al.   Current Alzheimer Research

Physical Activity, Physical Function, and Incident Dementia in Elderly Men: The Honolulu-Asia Aging Study

(2011) D. R. Taaffe et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Endurance factors improve hippocampal neurogenesis and spatial memory in mice

(2011) T. Kobilo et al.   LEARNING & MEMORY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

(2011) Karim Belarbi et al.   NEUROBIOLOGY OF DISEASE

Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease

(2010) J. Kálmán et al.   ACTA NEUROLOGICA SCANDINAVICA

Physical Activity and Alzheimer Disease Course

(2010) Nikolaos Scarmeas et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Effect of Apolipoprotein E epsilon4 on the association between health behaviors and cognitive function in late midlife

(2010) Severine Sabia et al.   Molecular Neurodegeneration

Will testing for apolipoprotein E assist in tailoring dementia risk reduction? A review

(2009) Lee-Fay Low et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers

(2008) Sean P. Deeny et al.   BIOLOGICAL PSYCHOLOGY

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

(2008) Nicola T. Lautenschlager et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

(2008) A. Parachikova et al.   NEUROBIOLOGY OF DISEASE

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON