Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging

(2019) Ceereena Ubaida-Mohien et al.   Frontiers in Physiology

Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

(2019) Zsofia Turi et al.   Aging-US

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

Muscle‐specific changes in protein synthesis with aging and reloading after disuse atrophy

(2019) Benjamin F. Miller et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

(2018) Marta Gonzalez-Freire et al.   AGING CELL

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction

(2018) Alberto Diaz-Ruiz et al.   AGING CELL

Skeletal muscle mass is controlled by the MRF4–MEF2 axis

(2018) Stefano Schiaffino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

(2018) Irene Franco et al.   Nature Communications

A need for NAD+ in muscle development, homeostasis, and aging

(2018) Michelle F. Goody et al.   Skeletal Muscle

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

(2018) Ana Luisa Cardoso et al.   AGEING RESEARCH REVIEWS

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

(2018) Towfique Raj et al.   NATURE GENETICS

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3

(2018) Yunzhi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages regulate the clearance of living cells by calreticulin

(2018) Dmitri V. Krysko et al.   Nature Communications

Energy Metabolism and Ageing in the Mouse: A Mini-Review

(2017) Vian Azzu et al.   GERONTOLOGY

Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice

(2017) James B. Papizan et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis and ageing: insights from long-lived mutant mice

(2017) William A. Sands et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure and function of human muscle fibres and muscle proteome in physically active older men

(2017) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women

(2017) Jamie N Justice et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

A review of human diseases caused or exacerbated by aberrant complement activation

(2017) Patrick L. McGeer et al.   NEUROBIOLOGY OF AGING

HMGB proteins and arthritis

(2017) Noboru Taniguchi et al.   Human Cell

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

(2017) Marta Murgia et al.   Cell Reports

Exercise and the Skeletal Muscle Epigenome

(2017) Sean L. McGee et al.   Cold Spring Harbor Perspectives in Medicine

Effects of Exercise and Aging on Skeletal Muscle

(2017) Giovanna Distefano et al.   Cold Spring Harbor Perspectives in Medicine

Differentially expressed alternatively spliced genes in skeletal muscle from cancer patients with cachexia

(2017) Ashok Narasimhan et al.   Journal of Cachexia Sarcopenia and Muscle

Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: a pilot study

(2017) H. Alexander Ebhardt et al.   Journal of Cachexia Sarcopenia and Muscle

Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways

(2016) Mehroz Ehsan et al.   ATHEROSCLEROSIS

Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature

(2016) Thomas Gobbetti et al.   BIOLOGICAL CHEMISTRY

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

Impact of aging on mitochondrial function in cardiac and skeletal muscle

(2016) R.T. Hepple   FREE RADICAL BIOLOGY AND MEDICINE

Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians

(2016) Sally Spendiff et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

(2016) Panagiotis Papasaikas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

(2016) Ling Yang et al.   Cell Reports

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

(2016) Daniel M. Waldera-Lupa et al.   Aging-US

Effects of aging, exercise, and disease on force transfer in skeletal muscle

(2015) David C. Hughes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolome and proteome changes with aging in Caenorhabditis elegans

(2015) Neil Copes et al.   EXPERIMENTAL GERONTOLOGY

Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis

(2015) Tyler J. Kirby et al.   JOURNAL OF APPLIED PHYSIOLOGY

Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults

(2015) María Laura Messi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of Inflammation in Muscle Homeostasis and Myogenesis

(2015) Domiziana Costamagna et al.   MEDIATORS OF INFLAMMATION

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Leveraging transcript quantification for fast computation of alternative splicing profiles

(2015) Gael P. Alamancos et al.   RNA

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury

(2015) Tatsuki Matsumoto et al.   PLoS One

1-Dodecyl-3-Methylimidazolium Chloride-Assisted Sample Preparation Method for Efficient Integral Membrane Proteome Analysis

(2014) Qun Zhao et al.   ANALYTICAL CHEMISTRY

“IDEAL” Aging Is Associated with Lower Resting Metabolic Rate: The Baltimore Longitudinal Study of Aging

(2014) Jennifer A. Schrack et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Difference in Muscle Quality over the Adult Life Span and Biological Correlates in the Baltimore Longitudinal Study of Aging

(2014) Ann Zenobia Moore et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sarcopenia-Related Parameters and Incident Disability in Older Persons: Results From the “Invecchiare in Chianti” Study

(2014) Matteo Cesari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates

(2014) Stephanie A. Studenski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inhibition of JAK-STAT signaling stimulates adult satellite cell function

(2014) Feodor D Price et al.   NATURE MEDICINE

Grip Strength across the Life Course: Normative Data from Twelve British Studies

(2014) Richard M. Dodds et al.   PLoS One

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

(2014) Marta Gonzalez-Freire et al.   Frontiers in Aging Neuroscience

A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys

(2013) Thomas D. Pugh et al.   AGING CELL

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Changes in splicing factor expression are associated with advancing age in man

(2013) Alice C. Holly et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Molecular Networks of Human Muscle Adaptation to Exercise and Age

(2013) Bethan E. Phillips et al.   PLoS Genetics

Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders

(2013) Sarah M. Senf   Frontiers in Physiology

Statistical Inference from Multiple iTRAQ Experiments without Using Common Reference Standards

(2012) Shelley M. Herbrich et al.   JOURNAL OF PROTEOME RESEARCH

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

(2011) Lorna W. Harries et al.   AGING CELL

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells

(2011) Yuexi Wang et al.   PROTEOMICS

Associations between energy demands, physical activity, and body composition in adult humans between 18 and 96 y of age

(2010) John R Speakman et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium

(2010) Freya L. Sheeran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Understanding sarcopenia as a geriatric syndrome

(2009) Alfonso J Cruz-Jentoft et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Klhl31 is associated with skeletal myogenesis and its expression is regulated by myogenic signals and Myf-5

(2009) Alaa Abou-Elhamd et al.   MECHANISMS OF DEVELOPMENT

Proteomics of skeletal muscle aging

(2009) Philip Doran et al.   PROTEOMICS

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS