Plant Natural Flavonoids Against Multidrug Resistant Pathogens

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

(2020) Elizabeth J. Culp et al.   NATURE

The Science of Antibiotic Discovery

(2020) Kim Lewis   CELL

Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria

(2020) Yuan Liu et al.   Advanced Science

A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens

(2020) Meirong Song et al.   Nature Microbiology

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

(2020) James K. Martin et al.   CELL

De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications

(2020) Shuimu Lin et al.   ACCOUNTS OF CHEMICAL RESEARCH

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

(2020) Kumar Sachin Singh et al.   NATURE

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action

(2019) Jason H. Yang et al.   CELL

Synthetic flavonoids with antimicrobial activity: a review

(2019) L.G. Sarbu et al.   JOURNAL OF APPLIED MICROBIOLOGY

Electrically induced bacterial membrane-potential dynamics correspond to cellular proliferation capacity

(2019) James P. Stratford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

(2019) Wooseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Flavones from Morus alba against Methicillin-Resistant Staphylococcus aureus via Targeting the Proton Motive Force and Membrane Permeability

(2019) Shuai-Cheng Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

A metagenomic strategy for harnessing the chemical repertoire of the human microbiome

(2019) Yuki Sugimoto et al.   SCIENCE

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

(2019) Shuai-Cheng Wu et al.   Frontiers in Microbiology

The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria

(2019) Dieter Meier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The biomass distribution on Earth

(2018) Yinon M. Bar-On et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

(2018) Bradley M. Hover et al.   Nature Microbiology

Precise and efficient genome editing in Klebsiella pneumoniae using CRISPR-Cas9 and CRISPR-assisted cytidine deaminase

(2018) Yu Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

(2018) Achara Raksat et al.   JOURNAL OF NATURAL PRODUCTS

A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes

(2018) Catarina Dias et al.   Nature Communications

Phytocompounds modulating Aquaporins: Clinical benefits are anticipated

(2018) Piero Portincasa et al.   FOOD CHEMISTRY

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

(2017) Junying Ma et al.   Nature Communications

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

(2016) John Chu et al.   Nature Chemical Biology

Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase

(2016) Ridao Chen et al.   Nature Chemical Biology

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficientAcinetobacter baumannii

(2016) Joseph M. Boll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance fighters

(2016) K. Kupferschmidt   SCIENCE

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids

(2016) Vera Pader et al.   Nature Microbiology

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Applying thermodynamic profiling in lead finding and optimization

(2015) Gerhard Klebe   NATURE REVIEWS DRUG DISCOVERY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus

(2013) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Flavonoids and their glycosides, including anthocyanins

(2011) Nigel C. Veitch et al.   NATURAL PRODUCT REPORTS

Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study

(2010) Marie-Laurence Lambert et al.   LANCET INFECTIOUS DISEASES

Prenylated Isoflavonoids: Botanical Distribution, Structures, Biological Activities and Biotechnological Studies. An Update (1995 – 2006)

(2009) Bruno Botta et al.   CURRENT MEDICINAL CHEMISTRY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES