mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1‐MMP Endocytosis Arrest

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macropinocytosis confers resistance to therapies targeting cancer anabolism

(2020) Vaishali Jayashankar et al.   Nature Communications

Cross-Talk Between the Tumor Microenvironment, Extracellular Matrix, and Cell Metabolism in Cancer

(2020) Mona Nazemi et al.   Frontiers in Oncology

Direct measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia

(2020) E. Dalaka et al.   Science Advances

Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia

(2020) Anna Zagryazhskaya-Masson et al.   JOURNAL OF CELL BIOLOGY

A large collection of integrated genomically characterized patient-derived xenografts highlighting the heterogeneity of triple-negative breast cancer

(2019) F. Coussy et al.   INTERNATIONAL JOURNAL OF CANCER

Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis

(2019) Xinquan Liu et al.   International Journal of Nanomedicine

Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells

(2019) Ritesh K. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

At a glance: A history of autophagy and cancer

(2019) Xin Wen et al.   SEMINARS IN CANCER BIOLOGY

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

(2019) Robin Ferrari et al.   Nature Communications

Local actin polymerization during endocytic carrier formation

(2018) Claudia Hinze et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tks adaptor proteins at a glance

(2018) Priyanka Saini et al.   JOURNAL OF CELL SCIENCE

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

(2018) Elvira Infante et al.   Nature Communications

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

(2017) Michel Nofal et al.   MOLECULAR CELL

Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration

(2017) Nadia Elkhatib et al.   SCIENCE

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

P-mTOR Expression and Implication in Breast Carcinoma: A Systematic Review and Meta-Analysis

(2017) Xian-Fei Ding et al.   PLoS One

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

(2016) Florian Grahammer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

(2016) Brett A. Morris et al.   EBioMedicine

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

(2015) Valentina Marchesin et al.   JOURNAL OF CELL BIOLOGY

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

V-ATPase/mTOR Signaling Regulates Megalin-Mediated Apical Endocytosis

(2014) Eva Maria Gleixner et al.   Cell Reports

Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells

(2013) Ved P. Sharma et al.   CURRENT BIOLOGY

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics

(2010) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE