Zebrafish Models for the Safety and Therapeutic Testing of Nanoparticles with a Focus on Macrophages

Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs

(2021) Yufei Xie et al.   Frontiers in Cell and Developmental Biology

Therapeutic Manipulation of Tumor-associated Macrophages: Facts and Hopes from a Clinical and Translational Perspective

(2021) Paola Allavena et al.   CLINICAL CANCER RESEARCH

Innate immune evasion revealed in a colorectal zebrafish xenograft model

(2021) Vanda Póvoa et al.   Nature Communications

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

(2021) Weisen Zhang et al.   Advanced Science

Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

(2021) Jae-Geun Lee et al.   Cells

Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina

(2021) Salvatore L. Stella et al.   Cells

3D Cell Culture Models: Drug Pharmacokinetics, Safety Assessment, and Regulatory Consideration

(2021) Hongbing Wang et al.   CTS-Clinical and Translational Science

Stab2-Mediated Clearance of Supramolecular Polymer Nanoparticles in Zebrafish Embryos

(2020) Victorio Saez Talens et al.   BIOMACROMOLECULES

ZnO Nanoparticles Induced Caspase-Dependent Apoptosis in Gingival Squamous Cell Carcinoma through Mitochondrial Dysfunction and p70S6K Signaling Pathway

(2020) Shih-Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions

(2020) Nils‐Jørgen Knudsen Dal et al.   Small

Anti–Inflammatory and Antioxidant Properties of the Ethanol Extract of Clerodendrum Cyrtophyllum Turcz in Copper Sulfate-Induced Inflammation in Zebrafish

(2020) Thu Hang Nguyen et al.   Antioxidants

Combined Therapy for Alzheimer’s Disease: Tacrine and PAMAM Dendrimers Co-Administration Reduces the Side Effects of the Drug without Modifying its Activity

(2020) Daniela E. Igartúa et al.   AAPS PHARMSCITECH

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

(2020) Xiaodan Qin et al.   Jove-Journal of Visualized Experiments

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

(2020) Xuezhi Yang et al.   CELL PROLIFERATION

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

(2020) Berna Kaya et al.   Cell Reports

The Relationship Between Gut Microbiota and Inflammatory Diseases: The Role of Macrophages

(2020) Ji Wang et al.   Frontiers in Microbiology

Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis

(2020) Agnese Kocere et al.   EBioMedicine

Zebrafish as a Model for Fish Diseases in Aquaculture

(2020) Louise von Gersdorff Jørgensen   Pathogens

Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy

(2020) Shuai Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis

(2020) Laura Gambari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delivering the power of nanomedicine to patients today

(2020) Matthieu Germain et al.   JOURNAL OF CONTROLLED RELEASE

Single-cell imaging of human cancer xenografts using adult immunodeficient zebrafish

(2020) Chuan Yan et al.   Nature Protocols

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

(2020) Sandra Valle et al.   Nature Communications

Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment

(2020) Pablo Cabezas-Sáinz et al.   Cells

Gut Microbiota and Immune System Interactions

(2020) Ji Youn Yoo et al.   Microorganisms

Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

(2020) Yihua Yang et al.   BIOMATERIALS

Polymeric Nanoparticles-Based Brain Delivery with Improved Therapeutic Efficacy of Ginkgolide B in Parkinson’s Disease

(2020) Yuying Zhao et al.   International Journal of Nanomedicine

Zebrafish as a preclinical in vivo screening model for nanomedicines

(2019) Sandro Sieber et al.   ADVANCED DRUG DELIVERY REVIEWS

The zebrafish model of tuberculosis - no lungs needed

(2019) Ghada Bouz et al.   CRITICAL REVIEWS IN MICROBIOLOGY

The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation

(2019) Emma R. Dorris et al.   JOURNAL OF IMMUNOLOGY

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo

(2019) Sandro Sieber et al.   Nanomedicine-Nanotechnology Biology and Medicine

The biodistribution and immuno-responses of differently shaped non-modified gold particles in zebrafish embryos

(2019) M. van Pomeren et al.   Nanotoxicology

Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy

(2019) Sha Xiong et al.   MOLECULAR PHARMACEUTICS

Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test

(2019) Sandra Vranic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

(2019) Chuan Yan et al.   CELL

A Manganese-Superoxide Dismutase From Thermus thermophilus HB27 Suppresses Inflammatory Responses and Alleviates Experimentally Induced Colitis

(2019) Yang Sheng et al.   INFLAMMATORY BOWEL DISEASES

InCl3 mediated heteroarylation of indoles and their derivatization via C H activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis

(2019) Rajnikanth Sunke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages

(2019) Samuel Seoane et al.   JOURNAL OF PATHOLOGY

Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile

(2019) Maximo Coronado et al.   Frontiers in Immunology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system

(2019) Latufa Youssouf et al.   CARBOHYDRATE POLYMERS

Nanomaterials meet zebrafish: Toxicity evaluation and drug delivery applications

(2019) Hao-Ran Jia et al.   JOURNAL OF CONTROLLED RELEASE

The size and composition of polymeric nanocapsules dictate their interaction with macrophages and biodistribution in zebrafish

(2019) José Crecente-Campo et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

(2019) Guorong Hu et al.   Frontiers in Immunology

Adult immune compromised zebrafish for xenograft cell transplantation studies

(2019) Chuan Yan et al.   EBioMedicine

Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review

(2019) Tateiwa et al.   Cells

Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease

(2019) Tongkai Chen et al.   ACS Applied Materials & Interfaces

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

(2019) Sasha Jardine et al.   GASTROENTEROLOGY

Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

(2019) Ibrahim Javed et al.   Nature Communications

Zebrafish embryo as a replacement model for initial biocompatibility studies of biomaterials and drug delivery systems

(2019) Theresa S.P. Rothenbücher et al.   Acta Biomaterialia

Longitudinal and quantitative assessment platform for concurrent analysis of anti-tumor efficacy and cardiotoxicity of nano-formulated medication in vivo

(2019) Wei-Ming Tu et al.   ANALYTICA CHIMICA ACTA

Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles

(2019) Xiang Li et al.   CHEMOSPHERE

Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus

(2019) Marie Cerna   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toxicological study of metal and metal oxide nanoparticles in zebrafish

(2019) Changcun Bai et al.   JOURNAL OF APPLIED TOXICOLOGY

Macrophages in Zebrafish Models of Liver Diseases

(2019) Arkadi Shwartz et al.   Frontiers in Immunology

Developments in zebrafish avatars as radiotherapy sensitivity reporters — towards personalized medicine

(2019) Bruna Costa et al.   EBioMedicine

Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses

(2019) Anfray et al.   Cells

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

(2018) Frederick Campbell et al.   ACS Nano

Synergistic Toxicity Produced by Mixtures of Biocompatible Gold Nanoparticles and Widely Used Surfactants

(2018) Aurora L. Ginzburg et al.   ACS Nano

Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy

(2018) Zhiqi Xie et al.   Acta Biomaterialia

Porous Porphyrin-Based Organosilica Nanoparticles for NIR Two-Photon Photodynamic Therapy and Gene Delivery in Zebrafish

(2018) Chiara Mauriello Jimenez et al.   ADVANCED FUNCTIONAL MATERIALS

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease

(2018) Holm H. Uhlig et al.   Annual Review of Immunology

Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis

(2018) Yin Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Developmental toxicity, oxidative stress and immunotoxicity induced by three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in zebrafish embryos

(2018) Hui Li et al.   CHEMOSPHERE

Implications of macrophage polarization in autoimmunity

(2018) Samanta C. Funes et al.   IMMUNOLOGY

Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish

(2018) Abraham Heriberto Garcia Campoy et al.   International Journal of Nanomedicine

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization

(2018) Daniela E. Igartúa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells

(2018) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Bilayer polymeric nanocapsules: A formulation approach for a thermostable and adjuvanted E. coli antigen vaccine

(2018) José Crecente-Campo et al.   JOURNAL OF CONTROLLED RELEASE

Effects of silver nanoparticles with different dosing regimens and exposure media on artificial ecosystem

(2018) Jingwen Zeng et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Ecotoxicity of different-shaped silver nanoparticles: Case of zebrafish embryos

(2018) Natalia B. Abramenko et al.   JOURNAL OF HAZARDOUS MATERIALS

Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish

(2018) Narahari Rishitha et al.   LIFE SCIENCES

Advanced tools for the safety assessment of nanomaterials

(2018) Bengt Fadeel et al.   Nature Nanotechnology

An orthotopic glioblastoma animal model suitable for high-throughput screenings

(2018) Linda Pudelko et al.   NEURO-ONCOLOGY

Cadmium exposure exacerbates severe hyperlipidemia and fatty liver changes in zebrafish via impairment of high-density lipoproteins functionality

(2018) Jae-Yong Kim et al.   TOXICOLOGY IN VITRO

The Use of Chitosan-Coated Membrane Vesicles for Immunization Against Salmonid Rickettsial Septicemia in an Adult Zebrafish Model

(2018) Julia Tandberg et al.   Zebrafish

The zebrafish: A fintastic model for hematopoietic development and disease

(2018) Aniket V. Gore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Rapid Response Fluorescence Probe Enabled In Vivo Diagnosis and Assessing Treatment Response of Hypochlorous Acid-Mediated Rheumatoid Arthritis

(2018) Huan Feng et al.   Advanced Science

Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics

(2018) Rosemary Thwaite et al.   Frontiers in Immunology

Recent advances of polysaccharide-based nanoparticles for oral insulin delivery

(2018) Qiaobin Hu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae

(2018) Xiaolin Zhang et al.   International Journal of Nanomedicine

Minimum information reporting in bio–nano experimental literature

(2018) Matthew Faria et al.   Nature Nanotechnology

pH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish

(2018) Alexandra Van Driessche et al.   CHEMISTRY OF MATERIALS

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model

(2018) Denver D. Britto et al.   Disease Models & Mechanisms

A multifunctional drug nanocarrier for efficient anticancer therapy

(2018) Carmen Teijeiro-Valiño et al.   JOURNAL OF CONTROLLED RELEASE

Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model

(2018) Chung-I Yu et al.   Marine Drugs

Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

(2018) Berney Peng et al.   Materials Today

Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio)

(2018) Katharina Dach et al.   TOXICOLOGICAL SCIENCES

Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings

(2018) Haiqiang Liu et al.   ENVIRONMENTAL POLLUTION

Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity

(2017) Houcheng Cheng et al.   ENVIRONMENTAL POLLUTION

Zebrafish ( Danio rerio ) as a model to visualize infection dynamics of Vibrio anguillarum following intraperitoneal injection and bath exposure

(2017) Jacob Günther Schmidt et al.   FISH & SHELLFISH IMMUNOLOGY

ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

(2017) Carles Cornet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

(2017) Chun Y. Wong et al.   JOURNAL OF CONTROLLED RELEASE

Assessment of the permeability and toxicity of polymeric nanocapsules using the zebrafish model

(2017) Carmen Teijeiro-Valiño et al.   Nanomedicine

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles

(2017) Nadya Velikova et al.   Nanomedicine-Nanotechnology Biology and Medicine

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

(2017) Peter Popp Wibroe et al.   Nature Nanotechnology

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models

(2017) Rodrigo Castañeda et al.   PHYTOMEDICINE

Targeting tumor associated macrophages: The new challenge for nanomedicine

(2017) Fernando Torres Andón et al.   SEMINARS IN IMMUNOLOGY

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

(2017) Hui Ge et al.   Drug Design Development and Therapy

Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation

(2017) Jennifer Mesureur et al.   PLoS Pathogens

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles

(2017) Liyu Chen et al.   Frontiers in Neuroscience

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

(2017) Ping Li et al.   Frontiers in Pharmacology

Radiation-Sensitive Dendrimer-Based Drug Delivery System

(2017) Szu-Yuan Wu et al.   Advanced Science

Specific and Efficient Uptake of Surfactant-Free Poly(Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion

(2017) Julien Rességuier et al.   Frontiers in Immunology

Mapping the Glyco-Gold Nanoparticles of Different Shapes Toxicity, Biodistribution and Sequestration in Adult Zebrafish

(2017) Sivakoti Sangabathuni et al.   Scientific Reports

The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages

(2016) Kiavash Movahedi et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish

(2016) Minjie Chen et al.   AQUATIC TOXICOLOGY

Nanostructured recombinant cytokines: A highly stable alternative to short-lived prophylactics

(2016) Débora Torrealba et al.   BIOMATERIALS

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model

(2016) Arturas Kavaliauskis et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation

(2016) Jing Lu et al.   EMBO JOURNAL

Reproductive toxicity of azoxystrobin to adult zebrafish ( Danio rerio )

(2016) Fangjie Cao et al.   ENVIRONMENTAL POLLUTION

Combined toxicity of silica nanoparticles and methylmercury on cardiovascular system in zebrafish (Danio rerio) embryos

(2016) Junchao Duan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs

(2016) Kimberly C. Brannen et al.   ILAR JOURNAL

Developmental toxicity of auranofin in zebrafish embryos

(2016) Xiao-Yan Gao et al.   JOURNAL OF APPLIED TOXICOLOGY

Predicting the in vivo accumulation of nanoparticles in tumor based on in vitro macrophage uptake and circulation in zebrafish

(2016) Hyeyoun Chang et al.   JOURNAL OF CONTROLLED RELEASE

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo toxicological assessment of biologically synthesized silver nanoparticles in adult Zebrafish ( Danio rerio )

(2016) Chandran Krishnaraj et al.   JOURNAL OF HAZARDOUS MATERIALS

Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson’s Disease

(2016) Tongkai Chen et al.   MOLECULAR PHARMACEUTICS

Zebrafish as a model system for characterization of nanoparticles against cancer

(2016) Lasse Evensen et al.   Nanoscale

Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri

(2016) Rozalia Korbut et al.   PLoS One

Redox and pH Dual Responsive Polymer Based Nanoparticles for In Vivo Drug Delivery

(2016) Chung Yen Ang et al.   Small

Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines

(2016) Lambert Bodewein et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections

(2016) Roberto Díez-Martínez et al.   Scientific Reports

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

(2016) Chiranjib Chakraborty et al.   JOURNAL OF NANOBIOTECHNOLOGY

Toxicity Evaluation of New Engineered Nanomaterials in Zebrafish

(2016) Maria V. Brundo et al.   Frontiers in Physiology

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

In vivo toxicity assessment of angiogenesis and the live distribution of nano-graphene oxide and its PEGylated derivatives using the developing zebrafish embryo

(2015) Jinyoung Jeong et al.   CARBON

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

(2015) L. Ye et al.   DEVELOPMENT

An inducible transgene reports activation of macrophages in live zebrafish larvae

(2015) Leslie E. Sanderson et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration

(2015) Fabien Delaspre et al.   DIABETES

Toxic effects of magnesium oxide nanoparticles on early developmental and larval stages of zebrafish (Danio rerio)

(2015) Mehdi Ghobadian et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Silver nanoparticles affect the neural development of zebrafish embryos

(2015) Qi Xin et al.   JOURNAL OF APPLIED TOXICOLOGY

Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

(2015) Bryan Harper et al.   JOURNAL OF NANOPARTICLE RESEARCH

Studies on polymer-coated zinc oxide nanoparticles: UV-blocking efficacy and in vivo toxicity

(2015) Koyeli Girigoswami et al.   Materials Science & Engineering C-Materials for Biological Applications

Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish

(2015) Carina Beatrice Vibe et al.   Nanotoxicology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Identification of polarized macrophage subsets in zebrafish

(2015) Mai Nguyen-Chi et al.   eLife

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

(2015) Guangliang Wang et al.   eLife

Embryonic oxidative stress results in reproductive impairment for adult zebrafish

(2015) Trent A.C. Newman et al.   Redox Biology

Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

(2014) M. Nguyen-Chi et al.   Disease Models & Mechanisms

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

(2014) V. Torraca et al.   Disease Models & Mechanisms

The importance of nanoparticle shape in cancer drug delivery

(2014) Nghia P Truong et al.   Expert Opinion on Drug Delivery

Highly versatile immunostimulating nanocapsules for specific immune potentiation

(2014) Sara Vicente et al.   Nanomedicine

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation

(2014) A. Bernut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: Importance of zinc ions

(2014) Nadja Rebecca Brun et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Through the looking glass: witnessing host–virus interplay in zebrafish

(2014) Jean-Pierre Levraud et al.   TRENDS IN MICROBIOLOGY

SiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish

(2014) Xiang Li et al.   Scientific Reports

Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation

(2013) Kunal Bhattacharya et al.   ADVANCED DRUG DELIVERY REVIEWS

Anti-inflammatory compounds of “Qin-Jiao”, the roots of Gentiana dahurica (Gentianaceae)

(2013) Yan-Ming Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer

(2013) Shajesh Palantavida et al.   Nanomedicine-Nanotechnology Biology and Medicine

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Soybean Meal Induces Intestinal Inflammation in Zebrafish Larvae

(2013) Manuel I. Hedrera et al.   PLoS One

Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase

(2013) Fernando T. Andón et al.   Small

An adult zebrafish model for preclinical tuberculosis vaccine development

(2013) Kaisa E. Oksanen et al.   VACCINE

Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish

(2013) Nuno Palha et al.   PLoS Pathogens

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

The zebrafish as a model for paediatric diseases

(2012) Olli Lohi et al.   ACTA PAEDIATRICA

Targeting the Tumor Microenvironment for Cancer Therapy

(2012) N. E. Sounni et al.   CLINICAL CHEMISTRY

A model 450 million years in the making: zebrafish and vertebrate immunity

(2012) S. A. Renshaw et al.   Disease Models & Mechanisms

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Surface functionalities of gold nanoparticles impact embryonic gene expression responses

(2012) Lisa Truong et al.   Nanotoxicology

Retinoic Acid Signaling Plays a Restrictive Role in Zebrafish Primitive Myelopoiesis

(2012) Dong Liang et al.   PLoS One

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

(2012) Xiaopin Duan et al.   Small

Zebrafish-As an integrative model for twenty-first century toxicity testing

(2011) Nisha S. Sipes et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes

(2011) Samuli Rounioja et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

(2011) A. T. Nguyen et al.   Disease Models & Mechanisms

Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype

(2011) Yovani Marrero-Ponce et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator

(2010) R. T. Phennicie et al.   INFECTION AND IMMUNITY

Zebrafish as a Model Host for Candida albicans Infection

(2010) C. C. Chao et al.   INFECTION AND IMMUNITY

Hematopoietic development in the zebrafish

(2010) Elizabeth J. Paik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Chitosan-based nanostructures: A delivery platform for ocular therapeutics

(2009) Maria de la Fuente et al.   ADVANCED DRUG DELIVERY REVIEWS

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model

(2009) C. Michailidou et al.   Disease Models & Mechanisms

Zebrafish blood stem cells

(2009) Aye T. Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Zebrafish as a New Model for Herpes Simplex Virus Type 1 Infection

(2009) Javier S. Burgos et al.   Zebrafish

Zebrafish as a model for infectious disease and immune function

(2008) Con Sullivan et al.   FISH & SHELLFISH IMMUNOLOGY

Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas

(2008) Seung Woo Park et al.   GASTROENTEROLOGY

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