Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome

(2021) Malte Christoph Rühlemann et al.   NATURE GENETICS

Large-scale association analyses identify host factors influencing human gut microbiome composition

(2021) Alexander Kurilshikov et al.   NATURE GENETICS

Diversity and Function of Glial Cell Types in Multiple Sclerosis

(2021) Lucas Schirmer et al.   TRENDS IN IMMUNOLOGY

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

(2021) Louise Dupraz et al.   Cell Reports

Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions

(2020) Erin C. Davis et al.   DIGESTIVE DISEASES AND SCIENCES

The microbiome and inflammatory bowel disease

(2020) Kerri L. Glassner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effect of sex on multiple sclerosis risk and disease progression

(2020) Rhonda R Voskuhl   Multiple Sclerosis Journal

Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity

(2020) Erin A. Yamamoto et al.   Frontiers in Immunology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Human microbiome: an academic update on human body site specific surveillance and its possible role

(2020) Elakshi Dekaboruah et al.   ARCHIVES OF MICROBIOLOGY

The Gut–CNS Axis in Multiple Sclerosis

(2020) Atsushi Kadowaki et al.   TRENDS IN NEUROSCIENCES

Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis

(2020) Daiki Takewaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity

(2020) Theresa L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human microbiota and effectiveness of cancer chemotherapy

(2020) Yu.V. Shvets et al.   Experimental Oncology

IL-12 and IL-23/Th17 axis in systemic lupus erythematosus

(2019) Maddalena Larosa et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Mitchell T Wallin et al.   LANCET NEUROLOGY

Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

(2019) Denis Awany et al.   Frontiers in Genetics

What is new and relevant for sequencing-based microbiome research? A minireview

(2019) Alena M. Fricker et al.   Journal of Advanced Research

Gut Microbe to Brain Signaling: What Happens in Vagus…

(2019) Christine Fülling et al.   NEURON

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

‘RA and the microbiome: do host genetic factors provide the link?

(2019) Philippa M. Wells et al.   JOURNAL OF AUTOIMMUNITY

Intrauterine Microbiota: Missing, or the Missing Link?

(2019) Helen J. Chen et al.   TRENDS IN NEUROSCIENCES

Murine Genetic Background has a Stronger Impact on the Composition of the Gut Microbiota than Maternal Inoculation or Exposure to Unlike Exogenous Microbiota

(2019) Hila Korach-Rechtman et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

(2019) Pei Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Temporal development of the infant gut microbiome

(2019) Rebecca E. Moore et al.   Open Biology

Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond

(2019) Kwon et al.   Cells

The vaginal microbial communities of healthy expectant Brazilian mothers and its correlation with the newborn’s gut colonization

(2019) Priscila Dobbler et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

(2019) Shirong Liu et al.   Cell Host & Microbe

Determinants of IBD Heritability: Genes, Bugs, and More

(2018) Williams Turpin et al.   INFLAMMATORY BOWEL DISEASES

Th17 plasticity and its relevance to inflammatory bowel disease

(2018) Aito Ueno et al.   JOURNAL OF AUTOIMMUNITY

Translocation of a gut pathobiont drives autoimmunity in mice and humans

(2018) S. Manfredo Vieira et al.   SCIENCE

Host genetic variation and its microbiome interactions within the Human Microbiome Project

(2018) Raivo Kolde et al.   Genome Medicine

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

You are what you eat: diet, health and the gut microbiota

(2018) Niv Zmora et al.   Nature Reviews Gastroenterology & Hepatology

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

(2018) Mitja Mitrovič et al.   CELL

Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus

(2018) Taco A. van der Meulen et al.   JOURNAL OF AUTOIMMUNITY

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Human genetic variation and the gut microbiome in disease

(2017) Andrew Brantley Hall et al.   NATURE REVIEWS GENETICS

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationships between gastrointestinal microbiota and blood group antigens

(2017) Anuhya Gampa et al.   PHYSIOLOGICAL GENOMICS

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Dysbiosis Is Associated with Altered Short-Chain Fatty Acids and Serum-Free Fatty Acids in Systemic Lupus Erythematosus

(2017) Javier Rodríguez-Carrio et al.   Frontiers in Immunology

ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins

(2016) Emily R. Davenport et al.   BMC GENOMICS

Genetic Determinants of the Gut Microbiome in UK Twins

(2016) Julia K. Goodrich et al.   Cell Host & Microbe

Host Selection of Microbiota via Differential Adhesion

(2016) Kirstie McLoughlin et al.   Cell Host & Microbe

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2016) Aiden Haghikia et al.   IMMUNITY

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria

(2016) K L Flannigan et al.   Mucosal Immunology

Breaking down the gut microbiome composition in multiple sclerosis

(2016) Adrian Budhram et al.   Multiple Sclerosis Journal

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Association of host genome with intestinal microbial composition in a large healthy cohort

(2016) Williams Turpin et al.   NATURE GENETICS

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus

(2016) Zhixing He et al.   Gut Pathogens

Breaking down the gut microbiome composition in multiple sclerosis

(2016) Adrian Budhram et al.   Multiple Sclerosis Journal

The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies

(2016) Peng Zhang et al.   PeerJ

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Role of the Gut Microbiome in Modulating Arthritis Progression in Mice

(2016) Xiaofei Liu et al.   Scientific Reports

The gut microbiome in autoimmunity: Sex matters

(2015) Andres Gomez et al.   CLINICAL IMMUNOLOGY

The Gut Microbiome in Multiple Sclerosis

(2015) Daniel W. Mielcarz et al.   Current Treatment Options in Neurology

The immunogenetics of multiple sclerosis: A comprehensive review

(2015) Jill A. Hollenbach et al.   JOURNAL OF AUTOIMMUNITY

Genetics of autoimmune diseases: insights from population genetics

(2015) Paula S Ramos et al.   JOURNAL OF HUMAN GENETICS

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

A comprehensive repertoire of prokaryotic species identified in human beings

(2015) Perrine Hugon et al.   LANCET INFECTIOUS DISEASES

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

(2015) Lazaros Belbasis et al.   LANCET NEUROLOGY

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Genome-Wide Association Studies of the Human Gut Microbiota

(2015) Emily R. Davenport et al.   PLoS One

Testicular hypofunction and multiple sclerosis: Cause or consequence?

(2014) Claudio Voci   ANNALS OF NEUROLOGY

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden

(2014) Helga Westerlind et al.   BRAIN

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

The Genetic Predisposition and the Interplay of Host Genetics and Gut Microbiome in Crohn Disease

(2014) Hu Jianzhong   CLINICS IN LABORATORY MEDICINE

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β

(2014) Simona Rolla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

(2014) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

(2014) A. Hevia et al.   mBio

Analysis of the Human Gut Microbiome and Association With Disease

(2013) Gary D. Wu et al.   Clinical Gastroenterology and Hepatology

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease

(2013) Kareem Rashid Rumah et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Progress in Multiple Sclerosis Genetics

(2012) An Goris et al.   CURRENT GENOMICS

Infant antibiotic exposures and early-life body mass

(2012) L Trasande et al.   INTERNATIONAL JOURNAL OF OBESITY

Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis

(2012) Anthony T. Cao et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host Genes Related to Paneth Cells and Xenobiotic Metabolism Are Associated with Shifts in Human Ileum-Associated Microbial Composition

(2012) Tianyi Zhang et al.   PLoS One

Inflammatory Bowel Diseases Phenotype, C. difficile and NOD2 Genotype Are Associated with Shifts in Human Ileum Associated Microbial Composition

(2012) Ellen Li et al.   PLoS One

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunogenetic Architecture of Autoimmune Disease

(2012) A. Goris et al.   Cold Spring Harbor Perspectives in Biology

Predominant Effect of Host Genetics on Levels of Lactobacillus johnsonii Bacteria in the Mouse Gut

(2011) Keren Buhnik-Rosenblau et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple Sclerosis

(2011) Tzu-Yun McDowell et al.   NEUROEPIDEMIOLOGY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Genes, viruses and microbes

(2010) Alison Simmons   NATURE

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis

(2010) Adam E. Handel et al.   PLoS One

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Multiple Sclerosis and Regulatory T Cells

(2008) Cristina Maria Costantino et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY