Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Berberine alters gut microbial function through modulation of bile acids

(2021) Patricia G. Wolf et al.   BMC MICROBIOLOGY

Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways

(2021) Yanyan Wang et al.   Cells

Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

(2021) Jin-Dong Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-Like Peptide-2 and Improving the Gut Microbiota

(2021) Ying Wang et al.   Frontiers in Endocrinology

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

(2021) Xingxing Li et al.   npj Biofilms and Microbiomes

Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion

(2021) Chaoran Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

(2020) Wei-Jia Kong et al.   PHARMACOLOGY & THERAPEUTICS

Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans

(2020) Ayo P. Doumatey et al.   Frontiers in Cellular and Infection Microbiology

Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics

(2020) Wangxiao Tan et al.   Oxidative Medicine and Cellular Longevity

Berberine pharmacology and the gut microbiota: A hidden therapeutic link

(2020) Solomon Habtemariam   PHARMACOLOGICAL RESEARCH

Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

(2020) Gang Ren et al.   Frontiers in Pharmacology

Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE−/− Mice

(2020) Min Wu et al.   Frontiers in Pharmacology

Functional nano-vector boost anti-atherosclerosis efficacy of berberine in Apoe(/–) mice

(2020) Xiaolei Ma et al.   Acta Pharmaceutica Sinica B

Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes

(2020) Leyuan Li et al.   Gut Microbes

The effect of Berberine on weight loss in order to prevent obesity: A systematic review

(2020) Zahra Ilyas et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy

(2020) Xiao Ke et al.   Drug Design Development and Therapy

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

(2020) Solomon Habtemariam   Biomedicines

Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease

(2020) Caitlin Vanessa Lewis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment

(2020) Fan Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

(2020) Yifei Zhang et al.   Nature Communications

Synergistic Effect of Berberine-Based Chinese Medicine Assembled Nanostructures on Diarrhea-Predominant Irritable Bowel Syndrome In Vivo

(2020) Lei Li et al.   Frontiers in Pharmacology

Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice

(2020) Hui Cao et al.   Frontiers in Pharmacology

Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice

(2020) Meng Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence

(2020) Xinmei Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity

(2020) Qingxuan Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine

(2020) Xizhan Xu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults

(2019) Melissa Erickson et al.   Nutrients

Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome

(2019) Ziwei Song et al.   Microbiome

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3

(2019) Xi Xu et al.   FASEB JOURNAL

Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone

(2019) Shu-Rong Ma et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes

(2019) Xinmin S Li et al.   EUROPEAN HEART JOURNAL

Using herbal medicine to target the “microbiota-metabolism-immunity” axis as possible therapy for cardiovascular disease

(2019) Wang Anlu et al.   PHARMACOLOGICAL RESEARCH

Berberine Influences Blood Glucose via Modulating the Gut Microbiome in Grass Carp

(2019) Houjun Pan et al.   Frontiers in Microbiology

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy

(2019) Yanhai Feng et al.   PLoS One

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

(2019) Dongdong Wang et al.   PHARMACOLOGICAL REVIEWS

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice

(2019) Wang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine Inhibits Adipogenesis in Porcine Adipocytes via AMP‐Activated Protein Kinase‐Dependent and ‐Independent Mechanisms

(2019) Yongqing Yang et al.   LIPIDS

Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation

(2019) Masahiro Takahara et al.   Scientific Reports

Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target

(2019) Shengjie Yang et al.   Frontiers in Pharmacology

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

(2019) Cai‐Na Li et al.   PHYTOTHERAPY RESEARCH

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

(2019) Giovanni Tarantino et al.   Journal of Clinical Medicine

Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe −/− mice

(2018) Lin Zhu et al.   ATHEROSCLEROSIS

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway

(2018) Dan Liu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Enterococcus faecium WEFA23 from infant lessens high-fat-diet-induced hyperlipidemia via cholesterol 7-alpha-hydroxylase gene by altering the composition of gut microbiota in rats

(2018) Fuqing Huang et al.   JOURNAL OF DAIRY SCIENCE

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

(2018) W. Zhu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microbial modulation of cardiovascular disease

(2018) J. Mark Brown et al.   NATURE REVIEWS MICROBIOLOGY

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

(2018) Lina Xu et al.   PHARMACOLOGICAL RESEARCH

Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial

(2018) Jie Ming et al.   Trials

Gut microbiota derived metabolites in cardiovascular health and disease

(2018) Zeneng Wang et al.   Protein & Cell

Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration

(2018) Ru Feng et al.   Frontiers in Pharmacology

Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice

(2018) Yafei Shi et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice

(2018) Jie Yin et al.   JOURNAL OF PINEAL RESEARCH

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Lifestyle Intervention Decreases Urine Trimethylamine N -Oxide Levels in Prepubertal Children with Obesity

(2018) María Jesús Leal-Witt et al.   Obesity

Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials

(2018) Jianqing Ju et al.   PHYTOMEDICINE

Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice

(2018) Yongning Sun et al.   Nutrition & Diabetes

The Role of Gut Microbiota in Atherosclerosis and Hypertension

(2018) Junli Ma et al.   Frontiers in Pharmacology

Review of Biguanide (Metformin) Toxicity

(2018) George Sam Wang et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids

(2018) Shi-Jun Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A next generation probiotic, Akkermansia muciniphila

(2018) Qixiao Zhai et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation

(2018) Yuan Tian et al.   DRUG METABOLISM AND DISPOSITION

Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways

(2018) Yang Yu et al.   International Heart Journal

Safety and efficacy of statin therapy

(2018) Bhavin B. Adhyaru et al.   Nature Reviews Cardiology

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

(2018) Hong-Xin Cui et al.   Oxidative Medicine and Cellular Longevity

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

(2017) Xinmin S. Li et al.   EUROPEAN HEART JOURNAL

Comprehensive evaluation of SCFA production in the intestinal bacteria regulated by berberine using gas-chromatography combined with polymerase chain reaction

(2017) Lu-Lu Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Type 2 diabetes

(2017) Sudesna Chatterjee et al.   LANCET

Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

(2017) Yan Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels

(2017) Jian Hui Xu et al.   Molecular Medicine Reports

Atherosclerosis: Association between the gut microbiome and atherosclerosis

(2017) William T. Barrington et al.   Nature Reviews Cardiology

Amelioration of intestinal barrier dysfunction by berberine in the treatment of nonalcoholic fatty liver disease in rats

(2017) Donghao Li et al.   Pharmacognosy Magazine

Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine

(2017) Yan Wang et al.   Theranostics

Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats

(2017) Jing Gong et al.   Frontiers in Pharmacology

Dose-response effect of berberine on bile acid profile and gut microbiota in mice

(2016) Ying Guo et al.   BMC Complementary and Alternative Medicine

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

(2016) Meng Li et al.   Journal of Translational Medicine

Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

(2016) Runbin Sun et al.   MOLECULAR PHARMACOLOGY

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Role of gut microbiota in atherosclerosis

(2016) Annika Lindskog Jonsson et al.   Nature Reviews Cardiology

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Modulation of Microbiota-Gut-Brain Axis by Berberine Resulting in Improved Metabolic Status in High-Fat Diet-Fed Rats

(2016) Honglin Sun et al.   Obesity Facts

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

(2016) Ming-liang Chen et al.   mBio

Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese

(2016) Raphael N. Alolga et al.   Scientific Reports

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis

(2015) Rebecca C. Schugar et al.   CURRENT OPINION IN LIPIDOLOGY

Systematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease

(2015) Giovanni Tarantino et al.   Future Microbiology

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

(2015) Xiao-Yang Li et al.   Journal of Translational Medicine

A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

(2015) Shenghua Gu et al.   Molecular BioSystems

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

(2015) Hong-Mei Yan et al.   PLoS One

Berberine inhibits hepatic gluconeogenesisviathe LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

(2015) Shu-Jun Jiang   WORLD JOURNAL OF GASTROENTEROLOGY

Application of Berberine on Treating Type 2 Diabetes Mellitus

(2015) Bing Pang et al.   International Journal of Endocrinology

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

Transforming berberine into its intestine-absorbable form by the gut microbiota

(2015) Ru Feng et al.   Scientific Reports

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

The contributory role of gut microbiota in cardiovascular disease

(2014) W.H. Wilson Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

(2014) S. O'Neill et al.   Obesity Reviews

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats

(2013) C Y Shan et al.   JOURNAL OF ENDOCRINOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-Like Receptor 4 Activation in Microvascular Endothelial Cells Triggers a Robust Inflammatory Response and Cross Talk With Mononuclear Cells via Interleukin-6

(2012) Zhongyang Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

(2012) Xu Zhang et al.   PLoS One

Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats

(2011) Wei Chen et al.   AAPS PHARMSCITECH

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

(2011) Weidong Xie et al.   PLoS One

Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats

(2010) Yanwen Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

(2009) Yueshan Hu et al.   FITOTERAPIA

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Gut Microbiota and Its Possible Relationship With Obesity

(2009) John K. DiBaise et al.   MAYO CLINIC PROCEEDINGS

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

(2009) Hao Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine modulates insulin signaling transduction in insulin-resistant cells

(2009) Li-Zhong Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA