Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

(2020) Xue Wang et al.   Frontiers in Pharmacology

Role of Interleukin-6 in Depressive Disorder

(2020) Emily Yi-Chih Ting et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

(2020) Jian Qiu et al.   PHARMACOLOGY

Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

(2020) Chunjing Yang et al.   Frontiers in Pharmacology

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

(2019) Bei Zhang et al.   Frontiers in Cellular Neuroscience

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacokinetic considerations for current state-of-the-art antidepressants

(2019) Elżbieta Wyska   Expert Opinion on Drug Metabolism & Toxicology

Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis

(2019) Jia Jia Liu et al.   MOLECULAR PSYCHIATRY

Serum Levels of Tumor Necrosis Factor-α and Loudness Dependence of Auditory Evoked Potentials at Pretreatment and Posttreatment in Patients with Major Depressive Disorder

(2019) Bun-Hee Lee et al.   Brain Sciences

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database

(2018) Carol Coupland et al.   BMC Medicine

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

(2018) Ya-Lin Wang et al.   Journal of Neuroinflammation

Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells

(2018) Huimin Hu et al.   INFLAMMATION

Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder

(2018) Wei Wang et al.   Frontiers in Psychiatry

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

(2017) Mengmeng Li et al.   Journal of Neuroinflammation

Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms.

(2017) Rachel H. Salk et al.   PSYCHOLOGICAL BULLETIN

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment

(2016) Ole Kohler et al.   Current Neuropharmacology

Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation

(2016) Helena Kyunghee Kim et al.   JOURNAL OF PSYCHIATRIC RESEARCH

PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine

(2016) Wenda Xue et al.   Scientific Reports

Catalpol: A Potential Therapeutic for Neurodegenerative Diseases

(2015) B. Jiang et al.   CURRENT MEDICINAL CHEMISTRY

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

(2015) Ji-chun Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production

(2015) Li Wang et al.   NEUROSCIENCE LETTERS

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

(2015) Jun-Ming Wang et al.   PHYSIOLOGY & BEHAVIOR

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

(2015) Juanjuan Tang et al.   Scientific Reports

Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression

(2015) Cristiano Noto et al.   NEUROIMMUNOMODULATION

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice

(2014) Kai Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

The best way forward

(2014) Lisa M. Monteggia et al.   NATURE

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies

(2013) Amirhossein Modabbernia et al.   BIOLOGICAL PSYCHIATRY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Antioxidants as Antidepressants

(2012) Giovanni Scapagnini et al.   CNS DRUGS

Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion

(2012) Hui-Feng Zhu et al.   International Journal of Biological Sciences

Neurobiology of chronic mild stress: Parallels to major depression

(2012) Matthew N. Hill et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Plasma Glucose Lowering Mechanisms of Catalpol, an Active Principle from Roots of Rehmannia glutinosa, in Streptozotocin-Induced Diabetic Rats

(2011) Ja-Ping Shieh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

(2011) Jean-Philippe Guilloux et al.   JOURNAL OF NEUROSCIENCE METHODS

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY