Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

In Vitro Susceptibility of Plasmodium falciparum Isolates from the China–Myanmar Border Area to Piperaquine and Association with Candidate Markers

(2021) Yu Si et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distribution and temporal dynamics of P. falciparum chloroquine resistance transporter mutations associated with piperaquine resistance in Northern Cambodia

(2021) Biraj Shrestha et al.   JOURNAL OF INFECTIOUS DISEASES

Continued Low Efficacy of Artemether-Lumefantrine in Angola?

(2021) Charlotte Rasmussen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human genetics and malaria resistance

(2020) Silvia N. Kariuki et al.   HUMAN GENETICS

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

(2020) Ryan C. Henrici et al.   mBio

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance

(2020) Faiza Amber Siddiqui et al.   mBio

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei.

(2020) Nelson V. Simwela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

(2020) Rob W van der Pluijm et al.   LANCET

Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol

(2020) Mariangela L’Episcopia et al.   Parasites & Vectors

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

(2020) Nina F. Gnädig et al.   PLoS Pathogens

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

(2020) Luana C Mathieu et al.   eLife

Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response

(2020) Melissa R. Rosenthal et al.   ACS Infectious Diseases

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

(2020) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

‘Artemisinin Resistance’: Something New or Old? Something of a Misnomer?

(2020) Thomas E. Wellems et al.   TRENDS IN PARASITOLOGY

K13, the Cytostome, and Artemisinin Resistance

(2020) Stanley C. Xie et al.   TRENDS IN PARASITOLOGY

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

(2020) David S. Khoury et al.   TRENDS IN PARASITOLOGY

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

(2020) Aoli Xiong et al.   Cell Reports

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

(2020) Kathryn J. Wicht et al.   Annual Review of Microbiology

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

(2020) Clare R. Harding et al.   Nature Communications

Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently

(2020) Harvie P Portugaliza et al.   eLife

Case Report: The First Case of Genotypically Confirmed K13 Propeller Mutation in Sri Lanka and Its Implications on the Elimination Status of Malaria

(2020) Deepika Fernando et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Asymptomatic recrudescence after artemether–lumefantrine treatment for uncomplicated falciparum malaria: a systematic review and meta-analysis

(2020) Rida Mumtaz et al.   MALARIA JOURNAL

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport

(2020) Carla Calçada et al.   mBio

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

(2020) Aabha I. Sharma et al.   PLoS Genetics

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

(2020) Olivo Miotto et al.   PLoS Pathogens

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

(2019) Jerzy M. Dziekan et al.   Science Translational Medicine

The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial

(2019) Lorenz von Seidlein et al.   PLOS MEDICINE

Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy

(2019) M Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Temporizing Solution to “Artemisinin Resistance”

(2019) Jigang Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

(2019) Daniel M Parker et al.   eLife

Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum

(2019) Leila S. Ross et al.   Cell Host & Microbe

Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

(2019) William L Hamilton et al.   LANCET INFECTIOUS DISEASES

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

An alternative dogma on reduced artemisinin susceptibility: A new shadow from east to west

(2019) Thirumalaisamy P. Velavan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13

(2019) Romain Coppée et al.   Scientific Reports

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

(2019) Kit Kennedy et al.   PLOS BIOLOGY

Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates

(2019) Abigail R. Tirrell et al.   MALARIA JOURNAL

Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)

(2019) Jaishree Raman et al.   MALARIA JOURNAL

Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro

(2019) Ryan C. Henrici et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

(2019) Jonathan Kim et al.   NATURE

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

(2019) Xue Li et al.   PLoS Genetics

Stochastic Protein Alkylation by Antimalarial Peroxides

(2019) Joëlle Jourdan et al.   ACS Infectious Diseases

Origin and Spread of Evolving Artemisinin-Resistant Plasmodium falciparum Malarial Parasites in Southeast Asia

(2019) Matthew R. Hassett et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum

(2019) Miguel Silva et al.   LANCET INFECTIOUS DISEASES

Autophagy‐related protein Pf ATG18 participates in food vacuole dynamics and autophagy‐like pathway in Plasmodium falciparum

(2019) Palak Agrawal et al.   MOLECULAR MICROBIOLOGY

Evolution of resistance in vitro reveals mechanisms of artemisinin activity inToxoplasma gondii

(2019) Alex Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistance

(2019) Jyoti Chhibber-Goel et al.   International Journal for Parasitology-Drugs and Drug Resistance

Emergence and Spread of kelch13 Mutations Associated with Artemisinin Resistance in Plasmodium falciparum Parasites in 12 Thai Provinces from 2007 to 2016

(2018) Theerayot Kobasa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine

(2018) Angana Mukherjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?

(2018) Shalini Nair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance

(2018) Souvik Bhattacharjee et al.   BLOOD

Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance

(2018) Faiza A Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Drug resistance in Plasmodium

(2018) Kasturi Haldar et al.   NATURE REVIEWS MICROBIOLOGY

Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates

(2018) Tryphena Adams et al.   Parasites & Vectors

Evolutionary ARMS Race: Antimalarial Resistance Molecular Surveillance

(2018) Christiane Prosser et al.   TRENDS IN PARASITOLOGY

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

(2018) Selina Bopp et al.   Nature Communications

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite

(2018) Rowena E Martin et al.   CURRENT OPINION IN PHARMACOLOGY

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

(2018) Leila S. Ross et al.   Nature Communications

Dihydroartemisinin–Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance

(2018) Laura E. Heller et al.   BIOCHEMISTRY

Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites

(2018) Laura E. Heller et al.   BIOCHEMISTRY

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites

(2018) Ernst Jonscher et al.   Cell Host & Microbe

Mass drug administration with dihydroartemisinin-piperaquine and malaria transmission dynamics in The Gambia - a prospective cohort study

(2018) Julia Mwesigwa et al.   CLINICAL INFECTIOUS DISEASES

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

(2018) Duangkamon Loesbanluechai et al.   International Journal for Parasitology-Drugs and Drug Resistance

Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons

(2017) Reginald A. Kavishe et al.   FEBS Journal

Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia

(2017) Christian M. Parobek et al.   Genome Biology and Evolution

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

(2017) Sonia Agrawal et al.   JOURNAL OF INFECTIOUS DISEASES

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

(2017) Roberto Amato et al.   LANCET INFECTIOUS DISEASES

Emergence of Plasmodium falciparum triple mutant in Cambodia

(2017) Gabriele Rossi et al.   LANCET INFECTIOUS DISEASES

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

(2017) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

(2017) Angana Mukherjee et al.   MALARIA JOURNAL

Seasonal malaria chemoprevention: successes and missed opportunities

(2017) Matthew E. Coldiron et al.   MALARIA JOURNAL

Immunity as a predictor of anti-malarial treatment failure: a systematic review

(2017) Katherine O’Flaherty et al.   MALARIA JOURNAL

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

(2017) Mateusz M. Plucinski et al.   MALARIA JOURNAL

Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam

(2017) Ngo Viet Thanh et al.   MALARIA JOURNAL

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

(2017) Satish K. Dhingra et al.   mBio

Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites

(2017) Priyanka Bansal et al.   mBio

Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation

(2017) Kyle Jarrod McLean et al.   mBio

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

Split dosing of artemisinins does not improve antimalarial therapeutic efficacy

(2017) N. J. White et al.   Scientific Reports

A Unique Plasmodium falciparum K13 Gene Mutation in Northwest Ethiopia

(2016) Abebe Genetu Bayih et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

(2016) Youyou Tu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of the Artemisinin Binding Site for Translationally Controlled Tumor Protein (TCTP) by Bioorthogonal Click Chemistry

(2016) Weichao Li et al.   BIOCONJUGATE CHEMISTRY

Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled Trial

(2016) Thomas P. Eisele et al.   JOURNAL OF INFECTIOUS DISEASES

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Dihydroartemisinin–Piperaquine for the Prevention of Malaria in Pregnancy

(2016) Abel Kakuru et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms

(2016) Didier Ménard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

(2016) C. D. Goodman et al.   SCIENCE

Artemisinin Action and Resistance in Plasmodium falciparum

(2016) Leann Tilley et al.   TRENDS IN PARASITOLOGY

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites

(2016) Devendra Kumar Gupta et al.   Scientific Reports

Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border

(2016) Zenglei Wang et al.   Scientific Reports

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue

(2016) Kiall F. Suazo et al.   Scientific Reports

Artemether-lumefantrine and dihydroartemisinin-piperaquine exert inverse selective pressure on Plasmodium falciparum drug sensitivity associated haplotypes in Uganda

(2016) Aimee R. Taylor et al.   Open Forum Infectious Diseases

Distinctive origin of artemisinin-resistant Plasmodium falciparum on the China-Myanmar border

(2016) Run Ye et al.   Scientific Reports

No Robust Evidence of Lumefantrine Resistance

(2015) Kamal Hamed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ex VivoDrug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance

(2015) Suwanna Chaorattanakawee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

(2015) Amanda Hott et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

(2015) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

(2015)   BMC Medicine

Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

(2015) Valentine Duru et al.   BMC Medicine

Mitochondrial Membrane Potential in a Small Subset of Artemisinin-Induced DormantPlasmodium falciparumParasites In Vitro

(2015) Christopher L. Peatey et al.   JOURNAL OF INFECTIOUS DISEASES

Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial

(2015) Adoke Yeka et al.   JOURNAL OF INFECTIOUS DISEASES

A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance ofPlasmodium falciparumFollowing Artemisinin Treatment

(2015) Fang Huang et al.   JOURNAL OF INFECTIOUS DISEASES

Independent Emergence of thePlasmodium falciparumKelch Propeller Domain Mutant Allele C580Y in Guyana

(2015) Stella M. Chenet et al.   JOURNAL OF INFECTIOUS DISEASES

Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study

(2015) Michele D Spring et al.   LANCET INFECTIOUS DISEASES

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

(2015) Maya A Olshina et al.   MALARIA JOURNAL

Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007–2012

(2015) Zenglei Wang et al.   MALARIA JOURNAL

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

(2015) S. Bhatt et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation inpfcrt

(2015) Stéphane Pelleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development

(2015) Chan Choo Yap et al.   Frontiers in Cellular Neuroscience

Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa

(2015) Brandyce St. Laurent et al.   Nature Communications

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach

(2015) Lisa J. White et al.   PLOS MEDICINE

Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine

(2014) Meera Venkatesan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Malaria in Children in Zaire and Uíge Provinces, Angola

(2014) Mateusz M. Plucinski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

(2014) Anusha M. Gopalakrishnan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum

(2014) Nanhua Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin SensitivityIn Vitro

(2014) Chanaki Amaratunga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate

(2014) Andreas Martin Lisewski et al.   CELL

Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

(2014) Gisela Henriques et al.   JOURNAL OF INFECTIOUS DISEASES

Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study

(2014) Steve M. Taylor et al.   JOURNAL OF INFECTIOUS DISEASES

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children

(2014) Melissa D. Conrad et al.   PLoS One

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stagePlasmodium falciparum

(2013) Martha Clark et al.   BRITISH JOURNAL OF HAEMATOLOGY

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

(2013) Gisela Henriques et al.   MALARIA JOURNAL

The interplay between drug resistance and fitness in malaria parasites

(2013) Philip J. Rosenthal   MOLECULAR MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Reduced Susceptibility of Plasmodium falciparum to Artesunate in Southern Myanmar

(2013) Myat P. Kyaw et al.   PLoS One

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy

(2013) Sanjeev Krishna et al.   TRENDS IN PARASITOLOGY

Artemisinin resistance is a clear and present danger

(2013) Arjen M. Dondorp et al.   TRENDS IN PARASITOLOGY

Artemisinin resistance in Plasmodium falciparum: what is it really?

(2013) Pedro Eduardo Ferreira et al.   TRENDS IN PARASITOLOGY

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya

(2013) Steffen Borrmann et al.   Scientific Reports

Malaria Burden and Artemisinin Resistance in the Mobile and Migrant Population on the Thai–Myanmar Border, 1999–2011: An Observational Study

(2013) Verena I. Carrara et al.   PLOS MEDICINE

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria

(2012) Debashish Das et al.   CLINICAL INFECTIOUS DISEASES

Isoprenoid Biosynthesis Inhibition Disrupts Rab5 Localization and Food Vacuolar Integrity in Plasmodium falciparum

(2012) Ruth Howe et al.   EUKARYOTIC CELL

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

(2012) Aung Pyae Phyo et al.   LANCET

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

(2012) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis

(2012) Steve M Taylor et al.   LANCET INFECTIOUS DISEASES

In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam

(2012) Tran Hien et al.   MALARIA JOURNAL

Mechanisms ofin vitroresistance to dihydroartemisinin inPlasmodium falciparum

(2012) Long Cui et al.   MOLECULAR MICROBIOLOGY

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

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Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-PressuredPlasmodium falciparumParasites

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(2011) Youyou Tu   NATURE MEDICINE

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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

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Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

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Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

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Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro

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PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

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Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast

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High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

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Artemisinin‐Induced Dormancy inPlasmodium falciparum: Duration, Recovery Rates, and Implications in Treatment Failure

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The Molecular Mechanism of Action of Artemisinin—The Debate Continues

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Intrahost modeling of artemisinin resistance in Plasmodium falciparum

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Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

(2009) Nicholas J White et al.   MALARIA JOURNAL

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(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative genomics of the Rab protein family in Apicomplexan parasites

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Evidence of Artemisinin-Resistant Malaria in Western Cambodia

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(2008) N. J. White   SCIENCE

A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia

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