Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Melissa D. Conrad, Victor Asua, Shreeya Garg, David Giesbrecht, Karamoko Niare, Sawyer Smith, Jane F. Namuganga, Thomas Katairo, Jennifer Legac, Rebecca M. Crudale, Patrick K. Tumwebaze, Samuel L. Nsobya, Roland A. Cooper, Moses R. Kamya, Grant Dorsey, Jeffrey A. Bailey, Philip J. Rosenthal
Summary: This study identified multifocal emergence and spread of Plasmodium falciparum with partial resistance to artemisinins in Uganda. The emergence and spread of resistance were predominantly observed in areas where effective malaria control had been discontinued or transmission was unstable.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Parasitology
Linda E. Amoah, Kwame K. Asare, Donu Dickson, Sherik-Fa Anang, Abena Busayo, Dorcas Bredu, George Asumah, Nana Peprah, Alexander Asamoah, Benjamin Abuaku, Keziah L. Malm
Summary: Clinical presentations of malaria in Ghana are mainly caused by Plasmodium falciparum, with a minor contribution from Plasmodium malariae and Plasmodium ovale. PCR can detect low-density (submicroscopic) malaria infections, and more sensitive point-of-care tools are needed to diagnose these cases.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Brendan Fries, Carlos A. Guerra, Guillermo A. Garcia, Sean L. Wu, Jordan M. Smith, Jeremias Nzamio Mba Oyono, Olivier T. Donfack, Jose Osa Osa Nfumu, Simon Hay, David L. Smith, Andrew J. Dolgert
Summary: Different population layers performed differently in matching the gold standard distribution at different population densities. Choosing the appropriate population map has a significant impact on burden estimates in a malaria model.
Article
Microbiology
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C. Heimsch, Kristina Haeussler, Patrick Maloney, Palak Gosalia, Janina Preuss, Mahsa Rahbari, Oleksii Skorokhod, Elena Valente, Daniela Ulliers, Luigi Felice Simula, Kathrin Buchholz, Michael P. Hedrick, Paul Hershberger, Thomas D. Y. Chung, Michael R. Jackson, Evelin Schwarzer, Stefan Rahlfs, Lars Bode, Katja Becker, Anthony B. Pinkerton
Summary: This study reports on a highly selective PfGluPho inhibitor, SBI-0797750, which shows potent activity against Plasmodium parasites. The compound disturbs the redox potential and H2O2 homeostasis of the parasites, without harming red blood cell integrity and phagocytosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Vladimir Vigdorovich, Hardik Patel, Alexander Watson, Andrew Raappana, Laura Reynolds, William Selman, Suzannah Beeman, Paul T. Edlefsen, Stefan H. I. Kappe, D. Noah Sather
Summary: The currently approved malaria vaccine only provides partial protection and targets a single parasite protein (CSP). This study tested multiple additional vaccine targets in combination with CSP and found that certain combinations enhanced protection against malaria infection in mice. This research suggests that a multiprotein immunization approach could lead to higher levels of protection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Article
Microbiology
Danielle Stanisic, Mei-Fong Ho, Reshma Nevagi, Emily Cooper, Maddison Walton, Md Tanjir Islam, Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth, Michael F. Good
Summary: Malaria vaccine research has shifted towards whole-parasite vaccines, which present a broad repertoire of antigens to the immune system to limit antigenic polymorphism. This study developed an enhanced liposomal vaccine that induced protective immune responses in mice and strong cellular immune responses, making significant progress towards evaluating the vaccine in clinical trials.
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Abalinda M. Gorret, Rabbison Muhindo, Emma Baguma, Moses Ntaro, Edgar M. Mulogo, Molly Deutsch-Feldman, Jonathan J. Juliano, Dan Nyehangane, Ross M. Boyce
Summary: A study conducted in western Uganda found that malaria rapid diagnostic tests perform similarly in diagnosing children with Plasmodium falciparum malaria, whether using capillary or venous blood, with high sensitivity, specificity, and agreement between sample types. Only a few tests would have led to a different clinical diagnosis when following the manufacturer's recommended interpretation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Mohd Amirul Fitri A. Rahim, Sriwipa Chuangchaiya, Paisit Chanpum, Laun Palawong, Panuwat Kantee, Nor Diyana Dian, Inke Nadia D. Lubis, Paul C. S. Divis, Akira Kaneko, Kevin K. A. Tetteh, Zulkarnain Md Idris
Summary: This study investigated malaria infection, knowledge, attitudes, and practices related to malaria exposure in a rural community in northeastern Thailand. The results showed that the residents had adequate knowledge and awareness about malaria, but improvements were needed in positive attitudes and practices. The findings are important for informing malaria control measures and achieving the goal of malaria elimination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Trent D. Ashton, Anna Ngo, Paola Favuzza, Hayley E. Bullen, Maria R. Gancheva, Ornella Romeo, Molly Parkyn Schneider, Nghi Nguyen, Ryan W. J. Steel, Sandra Duffy, Kym N. Lowes, Helene Jousset Sabroux, Vicky M. Avery, Justin A. Boddey, Danny W. Wilson, Alan F. Cowman, Paul R. Gilson, Brad E. Sleebs
Summary: This study focuses on refining the physicochemical properties of a new antimalarial class, with the aim to improve aqueous solubility, metabolism, and reduce adverse effects. Although the optimized compounds show potent activity against asexual parasites, they exhibit modest activity against early-stage gametocytes and no activity against pre-erythrocytic liver parasites. Surprisingly, the refined physicochemical properties did not lead to improved oral efficacy in a mouse model of malaria compared to previous studies.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Brodie L. Bailey, William Nguyen, Anna Ngo, Christopher D. Goodman, Maria R. Gancheva, Paola Favuzza, Laura M. Sanz, Francisco-Javier Gamo, Kym N. Lowes, Geoffrey I. McFadden, Danny W. Wilson, Benoit Laleu, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs
Summary: The study identified a triazolopyrimidine compound with good activity against Plasmodium falciparum and high selectivity against human cells, but faced challenges such as slow onset of action and low aqueous solubility. Further optimization is needed for its development as a potential partner in anti-malarial treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Theresa Reiker, Monica Golumbeanu, Andrew Shattock, Lydia Burgert, Thomas A. Smith, Sarah Filippi, Ewan Cameron, Melissa A. Penny
Summary: Individual-based models are essential in the global fight against infectious diseases, but the complexity of the models can pose challenges for calibration. The authors propose using a Bayesian optimization framework to calibrate a complex malaria transmission simulator, resulting in improved fitting outcomes compared to previous calibrations.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinas, Akhil B. Vaidya
Editorial Material
Parasitology
Kyle Jarrod McLean, Marcelo Jacobs-Lorena
TRENDS IN PARASITOLOGY
(2016)
Article
Microbiology
Jessica D. Wiley, Emilio F. Merino, Priscilla M. Krai, Kyle J. McLean, Abhai K. Tripathi, Joel Vega-Rodriguez, Marcelo Jacobs-Lorena, Michael Klemba, Maria B. Cassera
Article
Multidisciplinary Sciences
Hiromi Ikadai, Kathryn Shaw Saliba, Stefan M. Kanzok, Kyle J. McLean, Takeshi Q. Tanaka, Jun Cao, Kim C. Williamson, Marcelo Jacobs-Lorena
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Microbiology
Yuemei Dong, Suchismita Das, Chris Cirimotich, Jayme A. Souza-Neto, Kyle J. McLean, George Dimopoulos
Article
Multidisciplinary Sciences
Kyle Jarrod McLean, Judith Straimer, Christine S. Hopp, Joel Vega-Rodriguez, Jennifer L. Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C. Dumoulin, Chantal T. Harris, Xinran Tong, Melanie J. Shears, Johan Ankarklev, Bjorn F. C. Kafsack, David A. Fidock, Photini Sinnis
SCIENTIFIC REPORTS
(2019)
Article
Infectious Diseases
Kyle Jarrod McLean, Marcelo Jacobs-Lorena
Editorial Material
Parasitology
Kyle Jarrod McLean, Jacquin C. Niles
Summary: The recent study reveals that a non-ApiAP2 DNA-binding protein in the Plasmodium falciparum genome serves as a transcription factor in the gametocytogenesis cascade and plays a crucial role in determining the distinct morphology of gametocytes.
TRENDS IN PARASITOLOGY
(2022)
Article
Biology
Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena
LIFE SCIENCE ALLIANCE
(2018)