Evolution of resistance in vitro reveals mechanisms of artemisinin activity inToxoplasma gondii

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis

(2019) Allen Hopper et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological Activities of Artemisinin Derivatives Beyond Malaria

(2019) Xiaoyan Liu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

(2019) Carlo Giannangelo et al.   TRENDS IN PARASITOLOGY

Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro

(2018) Kimberly F. Breglio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice

(2018) Ildiko Rita Dunay et al.   CLINICAL MICROBIOLOGY REVIEWS

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

(2018) Azadeh Seidi et al.   eLife

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase

(2018) Kevin M. Brown et al.   Cell Host & Microbe

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

(2018) Juliana M. Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dynamics of molecular evolution over 60,000 generations

(2017) Benjamin H. Good et al.   NATURE

Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice

(2017) Gaelle Lentini et al.   PLoS One

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

(2017) Thomas Efferth   SEMINARS IN CANCER BIOLOGY

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

(2017) Kevin M. Brown et al.   mBio

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii

(2017) Shaojun Long et al.   PLoS Pathogens

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

The Import of Proteins into the Mitochondrion ofToxoplasma gondii

(2016) Giel G. van Dooren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Failure of primary atovaquone prophylaxis for prevention of toxoplasmosis in hematopoietic cell transplant recipients

(2016) K. Gajurel et al.   Transplant Infectious Disease

Artemisinin Action and Resistance in Plasmodium falciparum

(2016) Leann Tilley et al.   TRENDS IN PARASITOLOGY

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

(2016) Hernan Lorenzi et al.   Nature Communications

Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii

(2016) Carla M. Cabral et al.   PLoS Pathogens

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo

(2015) Elizabeth Watts et al.   mBio

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

bz-rates : A Web Tool to Estimate Mutation Rates from Fluctuation Analysis

(2015) Alexandre Gillet-Markowska et al.   G3-Genes Genomes Genetics

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

The Peculiarities and Paradoxes of Plasmodium Heme Metabolism

(2014) Paul A. Sigala et al.   Annual Review of Microbiology

Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii

(2014) Andrew Farrell et al.   BMC GENOMICS

A Thiazole Derivative of Artemisinin Moderately ReducesToxoplasma gondiiCyst Burden in Infected Mice

(2014) Tracey L. Schultz et al.   JOURNAL OF PARASITOLOGY

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway

(2014) Min Lu et al.   TUMOR BIOLOGY

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

The global burden of congenital toxoplasmosis: a systematic review

(2013) Paul R Torgerson et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Characterisation of full-length mitochondrial copies and partial nuclear copies (numts) of the cytochrome b and cytochrome c oxidase subunit I genes of Toxoplasma gondii, Neospora caninum, Hammondia heydorni and Hammondia triffittae (Apicomplexa: Sarcocystidae)

(2013) Bjørn Gjerde   PARASITOLOGY RESEARCH

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

(2013) Selina E. R. Bopp et al.   PLoS Genetics

Distinct signalling pathways controlToxoplasmaegress and host-cell invasion

(2012) Sebastian Lourido et al.   EMBO JOURNAL

Mechanisms ofin vitroresistance to dihydroartemisinin inPlasmodium falciparum

(2012) Long Cui et al.   MOLECULAR MICROBIOLOGY

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiazole, Oxadiazole, and Carboxamide Derivatives of Artemisinin are Highly Selective and Potent Inhibitors ofToxoplasma gondii

(2010) Christopher P. Hencken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model

(2009) I. R. Dunay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inferring relative proportions of DNA variants from sequencing electropherograms

(2009) I. M. Carr et al.   BIOINFORMATICS

Tagging of Endogenous Genes in aToxoplasma gondiiStrain Lacking Ku80

(2009) My-Hang Huynh et al.   EUKARYOTIC CELL

Toxoplasmosis snapshots: Global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis

(2009) Georgios Pappas et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

(2009) Richard T. Eastman et al.   NATURE REVIEWS MICROBIOLOGY

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress

(2008) Nirmala Padmanabhan et al.   MOLECULAR BIOLOGY OF THE CELL