Mechanisms ofin vitroresistance to dihydroartemisinin inPlasmodium falciparum

Lack of Association of the S769N Mutation in Plasmodium falciparum SERCA (PfATP6) with Resistance to Artemisinins

(2012) Long Cui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Increasedpfmdr1Copy Number and Sequence Polymorphisms in Plasmodium falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-Lumefantrine

(2011) Nahla B. Gadalla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomewide Scan Reveals Amplification ofmdr1as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

(2011) Sofia Borges et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artesunate Tolerance in Transgenic Plasmodium falciparum Parasites Overexpressing a Tryptophan-Rich Protein

(2011) Guillaume Deplaine et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

(2011) Sachel Mok et al.   BMC GENOMICS

Malaria drug resistance is associated with defective DNA mismatch repair

(2011) Meryl A. Castellini et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

(2011) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones

(2010) Fátima Nogueira et al.   ACTA TROPICA

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spontaneous Mutations in thePlasmodium falciparumSarcoplasmic/ Endoplasmic Reticulum Ca2+-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies

(2010) Kazuyuki Tanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigations into the Role of the Plasmodium falciparum SERCA (PfATP6) L263E Mutation in Artemisinin Action and Resistance

(2010) S. G. Valderramos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum

(2010) M. Chavchich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

(2010) Dorothee Beez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum

(2010) M. Imwong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia

(2010) Harald Noedl et al.   CLINICAL INFECTIOUS DISEASES

Waking the Sleeping Beauty

(2010) François Nosten   JOURNAL OF INFECTIOUS DISEASES

Artemisinin‐Induced Dormancy inPlasmodium falciparum: Duration, Recovery Rates, and Implications in Treatment Failure

(2010) Franka Teuscher et al.   JOURNAL OF INFECTIOUS DISEASES

The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum

(2010) Jun Miao et al.   MOLECULAR MICROBIOLOGY

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

(2010) Jigar J. Patel et al.   MOLECULAR MICROBIOLOGY

Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether

(2010) Ramesh Chandra et al.   PARASITOLOGY INTERNATIONAL

Experimental Evolution of Resistance to Artemisinin Combination Therapy Results in Amplification of the mdr1 Gene in a Rodent Malaria Parasite

(2010) Louise A. Rodrigues et al.   PLoS One

Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

(2010) Xavier C. Ding et al.   TRENDS IN PARASITOLOGY

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Disruption of aPlasmodium falciparumMultidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

(2009) Dipak Kumar Raj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells

(2009) Oscar Akide-Ndunge et al.   MALARIA JOURNAL

Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

(2009) Pharath Lim et al.   MALARIA JOURNAL

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum

(2009) Jing Yuan et al.   Nature Chemical Biology

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

(2008) Onguma Natalang et al.   BMC GENOMICS

Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum

(2008) Azar Radfar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diversity of the sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6)

(2008) Sabina Dahlström et al.   INFECTION GENETICS AND EVOLUTION

Glucose-6-phosphate dehydrogenase deficiency

(2008) MD Cappellini et al.   LANCET

No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China

(2008) Guoqing Zhang et al.   MALARIA JOURNAL

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation

(2008) Joseph M Gonzales et al.   PLOS BIOLOGY