The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

(2020) Minrui Fan et al.   NATURE

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter

(2020) Sagnika Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

(2020) Chongyuan Wang et al.   eLife

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

(2020) Yan Wang et al.   eLife

A Rapid and Sensitive Nucleic Acid Amplification Technique for Mycoplasma Screening of Cell Therapy Products

(2020) Lisa Dreolini et al.   Molecular Therapy-Methods & Clinical Development

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+uptake

(2020) Horia Vais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of intact human MCU supercomplex with the auxiliary MICU subunits

(2020) Wei Zhuo et al.   Protein & Cell

Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter

(2019) Yangfei Xing et al.   Cell Reports

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

(2019) Yan Wang et al.   CELL

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

(2019) Mayara S. Bertolini et al.   mBio

Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

(2019) Roberta Tufi et al.   Cell Reports

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

(2019) Benjamin Gottschalk et al.   Nature Communications

Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

(2019) Ghazaleh Ashrafi et al.   NEURON

Molecular regulation of MCU: Implications in physiology and disease

(2018) Neeharika Nemani et al.   CELL CALCIUM

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

(2018) Maria Patron et al.   CELL DEATH AND DIFFERENTIATION

Cryo-EM structure of a mitochondrial calcium uniporter

(2018) Jiho Yoo et al.   SCIENCE

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

(2018) Chao Fan et al.   NATURE

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+

(2018) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity

(2018) Jennifer Wettmarshausen et al.   Cell Reports

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

(2015) Kira M. Holmström et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Regulation of the mitochondrial Ca2+ uniporter by MICU1 and MICU2

(2014) J. Kevin Foskett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

NCLX: The mitochondrial sodium calcium exchanger

(2013) Liron Boyman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

MCU encodes the pore conducting mitochondrial calcium currents

(2013) Dipayan Chaudhuri et al.   eLife

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Activity of the mitochondrial calcium uniporter varies greatly between tissues

(2012) Francesca Fieni et al.   Nature Communications

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Calmodulin as a direct detector of Ca2+ signals

(2011) Guido C Faas et al.   NATURE NEUROSCIENCE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays

(2010) Thomas E. Gunter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA