Review
Cell Biology
Jack G. Allen, Jeffery S. Tessem
Summary: The MCU Complex plays a crucial role in beta-cell function and insulin secretion by regulating mitochondrial calcium influx. Dysfunction in this complex can result in impaired insulin secretion.
Article
Biochemistry & Molecular Biology
Elianne P. Bulthuis, Merel J. W. Adjobo-Hermans, Bastiaan de Potter, Saskia Hoogstraten, Lisanne H. T. Wezendonk, Omar A. Z. Tutakhel, Liesbeth T. Wintjes, Bert van den Heuvel, Peter H. G. M. Willems, Erik-Jan Kamsteeg, M. Estela Rubio Gozalbo, Suzanne C. E. H. Sallevelt, Suzanne M. Koudijs, Joost Nicolai, Charlotte I. de Bie, Jessica E. Hoogendijk, Werner J. H. Koopman, Richard J. Rodenburg
Summary: In this study, the genetic, clinical, and cellular characteristics of two patients with SMDT1 variants and muscle problems were investigated. The variants were found to result in the absence of EMRE protein, formation of MCU subcomplex, and impaired mitochondrial Ca2+ uptake, potentially contributing to the muscle-related symptoms observed in the patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Md Imam Faizan, Tanveer Ahmad
Summary: Classical necroptosis signaling is mediated by death receptors and traditional caspase inhibitory signals, while a non-classical model of necroptosis with relatively unexplored molecular mechanism has emerged, showing close association with mitochondrial dysfunction. Contradictory reports complicate the definitiveness of this emerging model.
Article
Neurosciences
Lisa Schwarz, Karan Sharma, Lorenzo D. Dodi, Lara-Sophie Rieder, Petra Fallier-Becker, Nicolas Casadei, Julia C. Fitzgerald
Summary: A heterozygous point mutation Miro1 R272Q has been found in Parkinson's disease patients, which affects mitochondrial morphology and function, leading to impaired dopaminergic function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Claire Angebault, Mathieu Panel, Mathilde Lacote, Jennifer Rieusset, Alain Lacampagne, Jeremy Fauconnier
Summary: In the early stages of Duchenne muscular dystrophy (DMD), the heart exhibits impaired sarco-endoplasmic reticulum (SR/ER)-mitochondria interactions and mitochondrial dysfunction, resulting in disrupted mitochondrial Ca2+ homeostasis and complex I dysfunction. Treatment with metformin could reverse these abnormalities, offering a potential therapeutic perspective in DMD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Vikas Arige, Trayambak Pathak, J. Cory Benson, Martin T. Johnson, Ahmed Emam Abdelnaby, Natalia Lakomski, Nadine Hempel, Jung Min Han, Genevieve Dupont, David Yule, James Sneyd, Mohamed Trebak
Summary: The study demonstrates that MCU is a universal regulator of intracellular Ca2+ signaling across mammalian cell types, affecting Ca2+ signal transduction and nuclear translocation through multiple mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Katalin Marta, Prottoy Hasan, Macarena Rodriguez-Prados, Melanie Paillard, Gyorgy Hajnoczky
Summary: Mitochondrial Ca2+ uptake is crucial for meeting the fluctuating energy demands of cells and is mediated by the Ca2+ uniporter. Pharmacological manipulation of mtCU is key to understanding its physiological significance, but specific inhibitors have not been identified. Success in developing small molecule mtCU inhibitors is expected to have clinical impact in various diseases.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Akira Watanabe, Kousuke Maeda, Atsushi Nara, Mei Hashida, Mizune Ozono, Ayaka Nakao, Akiko Yamada, Yasuo Shinohara, Takenori Yamamoto
Summary: Mitochondrial calcium homeostasis is crucial in cell survival and aerobic metabolism. This study provides insights into the stoichiometry of the mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE), revealing tissue-specific differences and proposing a novel stoichiometric model.
Article
Multidisciplinary Sciences
Dorian Ziegler, David Vindrieux, Delphine Goehrig, Sara Jaber, Guillaume Collin, Audrey Griveau, Clotilde Wiel, Nadia Bendridi, Sophia Djebali, Valerio Farfariello, Natacha Prevarskaya, Lea Payen, Jacqueline Marvel, Sebastien Aubert, Jean-Michel Flaman, Jennifer Rieusset, Nadine Martin, David Bernard
Summary: The lack of ITPR2 in mice leads to improved aging, which is associated with a decreased number of contacts between mitochondria and endoplasmatic reticulum.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Karthik Ramachandran, Soumya Maity, Alagar R. Muthukumar, Soundarya Kandala, Dhanendra Tomar, Tarek Mohamed Abd El-Aziz, Cristel Allen, Yuyang Sun, Manigandan Venkatesan, Travis R. Madaris, Kevin Chiem, Rachel Truitt, Neelanjan Vishnu, Gregory Aune, Allen Anderson, Luis Martinez, Wenli Yang, James D. Stockand, Brij B. Singh, Subramanya Srikantan, W. Brian Reeves, Muniswamy Madesh
Summary: SARS-CoV-2 infection causes significant changes in cellular components such as mitochondria, ion channels, and protein quality control. The viral proteins selectively target cellular organelles, including the endoplasmic reticulum and mitochondria. Cyclosporin A has been found to alleviate cell death and cardiomyocyte damage.
Article
Biochemistry & Molecular Biology
Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk, Michal A. Zmijewski
Summary: The study reveals that calcitriol can directly affect the activity of the mitochondrial potassium channel in human astrocytoma cells, suggesting its potential role in regulating mitochondrial function.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Medicine, General & Internal
Katarzyna Konieczka, Josef Flammer
Summary: Flammer syndrome is characterized by primary vascular dysregulation and various symptoms and signs. While most patients are healthy, it can increase the risk of certain diseases like normal tension glaucoma. Treatment is recommended based on the severity of symptoms or potential contribution to disease progression. Studies suggest targeted therapy for FS not only alleviates symptoms but may also slow glaucoma damage in some cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Materials Science, Biomaterials
Mengting Xu, Jie Xing, Bo Yuan, Lulu He, Liheng Lu, Nengwen Chen, Peijun Cai, Aiguo Wu, Juan Li
Summary: Metal ions widely exist in biological systems and play important roles in biochemical processes. Monitoring and analyzing metal ions in biological systems can provide insights into physiological processes and disease causes. Organic small-molecule fluorescent probes are a promising method for metal ion detection due to their advantages in fluorescence quantum yield, modification, biocompatibility, sensitivity, and real-time detection. This review summarizes recent studies on fluorescent probes for alkali and alkaline earth metal ions in biological systems, including their structures and sensing mechanisms. The challenges, trends, and prospects of using fluorescent probes in metal ion detection are also discussed, aiming to provide guidance for future development in this field.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Biochemistry & Molecular Biology
Maithili Joshi, Siddhi Joshi, Mihir Khambete, Mariam Degani
Summary: Calcium dysregulation is associated with Alzheimer's disease (AD) and understanding its mechanisms is crucial for developing new therapies. This review provides a detailed account of the physiology of calcium homeostasis and its dysregulation in AD, as well as discussions on calcium channel blockers and multitarget molecules explored in AD research.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Cell Biology
Dominic Tscherrig, Rajesh Bhardwaj, Daniel Biner, Jan Dernic, Daniela Ross-Kaschitza, Christine Peinelt, Matthias A. Hediger, Martin Lochner
Summary: Changes in Ca2+ levels regulate many physiological functions, and the endoplasmic reticulum is the major Ca2+ store in cells. Store-operated calcium entry (SOCE) is a refilling process that involves protein-protein interactions between Ca2+ sensing STIM in the ER and Orai proteins in the plasma membrane, forming selective Ca2+ channels. Abnormal SOCE is associated with diseases and cancers, making STIM and Orai important therapeutic targets. Novel GSK-7975A-based molecular probes have been developed for studying SOCE in different cells and settings.
Article
Cell Biology
Nicola Fameli, Cornelis van Breemen, Klaus Groschner
Summary: The study provides evidence for the importance of junctional membrane architecture in cellular function. Through modeling and prediction, it is shown that nano-scale membrane spacing plays a crucial role in junctional ER Ca2+ refilling and signaling efficiency. Additionally, interactions between Ca2+ and the phospholipid membrane surface are suggested to support interfacial Ca2+ transport and receptor targeting. This research introduces a new concept in pathophysiology.
Article
Cell Biology
Satomi Ohtsuka, Yumi Miyai, Hiroyuki Mima, Masaki Magari, Yoichi Chiba, Futoshi Suizu, Hiroyuki Sakagami, Masaki Ueno, Hiroshi Tokumitsu
Summary: This study characterized the splice variants of mouse CaMKKI3/2 and found that CaMKKI3-3 and I3-3x were functionally active and likely to be bona fide CaMKIV kinases involved in the regulation of spermiogenesis.
