7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

Interleukin-20 inhibits the osteogenic differentiation of MC3T3-E1 cells via the GSK3β/β-catenin signalling pathway

(2021) Xi Chen et al.   ARCHIVES OF ORAL BIOLOGY

BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

(2020) Yan‐Man Zhou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tuna Bone Powder Alleviates Glucocorticoid‐Induced Osteoporosis via Coregulation of the NF‐κB and Wnt/β‐Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism

(2020) Jingjing Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence

(2020) Surya Narayan Pandey et al.   PSYCHOPHARMACOLOGY

Cxcl9l and Cxcr3.2 regulate recruitment of osteoclast progenitors to bone matrix in a medaka osteoporosis model

(2020) Quang Tien Phan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF promoted osteoblast migration and fracture healing by up‐regulating integrin β1 via TrkB‐mediated ERK1/2 and AKT signalling

(2020) Zitao Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

(2020) Zhenlei Zhao et al.   Molecular Metabolism

The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice

(2019) Xiangde Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

Psoralen accelerates bone fracture healing by activating both osteoclasts and osteoblasts

(2019) Tan Zhang et al.   FASEB JOURNAL

State of the art in osteoporosis risk assessment and treatment

(2019) J. Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Influence of Calcium Supplementation against Fluoride-Mediated Osteoblast Impairment in Vitro: Involvement of the Canonical Wnt/β-Catenin Signaling Pathway

(2019) Jinming Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of new beta-type Ti-40Nb implant materials, brain-derived neurotrophic factor, acetylcholine and nicotine on human mesenchymal stem cells of osteoporotic and non osteoporotic donors

(2018) Vivien Kauschke et al.   PLoS One

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Brain-Derived Neurotrophic Factor on the Neurogenesis and Osteogenesis in Bone Engineering

(2018) Qing Liu et al.   TISSUE ENGINEERING PART A

Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model

(2018) Vivien Kauschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss

(2018) Min Jiang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sophoridine from Sophora Flower Attenuates Ovariectomy Induced Osteoporosis through the RANKL-ERK-NFAT Pathway

(2017) Xiaoying Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

BDNF regulates the expression and secretion of VEGF from osteoblasts via the TrkB/ERK1/2 signaling pathway during fracture healing

(2017) Zitao Zhang et al.   Molecular Medicine Reports

Osteoporosis: Staying strong

(2017) Carolyn Brown   NATURE

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy

(2017) Benjamin Z. Leder   Current Osteoporosis Reports

Wnt signaling and cellular metabolism in osteoblasts

(2016) Courtney M. Karner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway

(2016) Yan-Qiu Liu et al.   Scientific Reports

Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells

(2016) Shoichiro Kokabu et al.   Stem Cells International

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders

(2016) Chaoyang Liu et al.   Translational Neurodegeneration

Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis

(2016) Bente Langdahl et al.   Therapeutic Advances in Musculoskeletal Disease

Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation

(2015) Rahul Agrawal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice

(2015) Chi Bun Chan et al.   CHEMISTRY & BIOLOGY

TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

(2015) Lei Gao et al.   JOURNAL OF NEUROCHEMISTRY

BDNF and its TrkB receptor in human fracture healing

(2014) Olaf Kilian et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling

(2014) Vivek Gupta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice

(2014) Meghan E. McGee-Lawrence et al.   BONE

Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

(2014) Xia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation

(2014) Ju-Young Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Replication

(2014) Paul Blainey et al.   NATURE METHODS

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Effects of ovariectomy on the changes in microarchitecture and material level properties in response to hind leg disuse in female rats

(2012) Laurent Maïmoun et al.   BONE

Effects of Phytoestrogen α-ZAL and Mechanical Stimulation on Proliferation, Osteoblastic Differentiation, and OPG/RANKL Expression in MC3T3-E1 Pre-Osteoblasts

(2012) Lu Liu et al.   Cellular and Molecular Bioengineering

P.2.019 BDNF/TrkB signaling in learning and memory: the effects of 7,8-dihydroxyflavone on object memory

(2012) E. Bollen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A Phytoestrogen Diarylheptanoid Mediates Estrogen Receptor/Akt/Glycogen Synthase Kinase 3β Protein-dependent Activation of the Wnt/β-Catenin Signaling Pathway

(2012) Kanit Bhukhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of BDNF in Multiple Myeloma Blocks Osteoclastogenesis via Down-Regulated Stroma-Derived RANKL Expression Both In Vitro and In Vivo

(2012) Li-Sha Ai et al.   PLoS One

Effects of Cheonnyuncho (Opuntia humifusa) seeds treatment on the mass, quality, and the turnover of bone in ovariectomized rats

(2011) Jieun Park et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma

(2011) Chun-Yan Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Bone remodelling at a glance

(2011) J. C. Crockett et al.   JOURNAL OF CELL SCIENCE

Bisphosphonates in the treatment of osteoporosis: a review of their contribution and controversies

(2011) Ian R. Reid   SKELETAL RADIOLOGY

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

(2009) Andreas Leibbrandt et al.   Annals of the New York Academy of Sciences

Bone remodeling in rheumatic disease: a question of balance

(2009) Nicole C. Walsh et al.   IMMUNOLOGICAL REVIEWS

Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis

(2009) Ichiro Takada et al.   Nature Reviews Rheumatology

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

(2008) Natalie A. Sims et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Potential new drug targets for osteoporosis

(2008) Chad Deal   Nature clinical practice. Rheumatology