Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

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Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

(2021) Guido Papa et al.   PLoS Pathogens

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

(2021) Christoph Muus et al.   NATURE MEDICINE

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

(2021) Yunkai Zhu et al.   Nature Communications

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

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Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

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Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

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Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

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The protein expression profile of ACE2 in human tissues

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Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

(2020) Hongjing Gu et al.   SCIENCE

Identification of required host factors for SARS-CoV-2 infection in human cells

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A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

(2020) Anna Bruchez et al.   SCIENCE

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

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Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

(2020) Lizhou Zhang et al.   Nature Communications

Multiplex assessment of protein variant abundance by massively parallel sequencing

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CADD: predicting the deleteriousness of variants throughout the human genome

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Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

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Landscape of X chromosome inactivation across human tissues

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A platform for functional assessment of large variant libraries in mammalian cells

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Quantitative analysis of mammalian translation initiation sites by FACS-seq

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LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus

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Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

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Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

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Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

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Enzymatic assembly of DNA molecules up to several hundred kilobases

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Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases

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