Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
D. Alejandro Canaria, Maia G. Clare, Bingyu Yan, Charlotte B. Campbell, Zachariah A. Ismaio, Nicole L. Anderson, Sungtae Park, Alexander L. Dent, Majid Kazemian, Matthew R. Olson
Summary: This study reveals the importance of IL-2 in the differentiation of Th9 cells, as IL-2 signaling is required for optimal NF-kB activation and IL-9 production. The addition of the NF-kB-activating cytokine IL-1 beta can rescue Th9 differentiation under IL-2 limiting conditions by enhancing the sensitivity of Th9 cells to limited IL-2 resources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qiong Luo, Yijun Liu, Ke Shi, Xuecheng Shen, Yaqi Yang, Xuejiao Liang, Liangliang Lu, Wenxuan Qiao, Airu Chen, Dongmei Hong, Yang Sun, Qiang Xu
Summary: IL-17 therapy has limited efficacy in autoimmune diseases, and a molecular complex containing SHP2 and Act1 mediates an alternative pathway for IL-17R signaling, which could be a therapeutic option for IL-17-related diseases.
Article
Multidisciplinary Sciences
Lihi Radomir, Matthias P. Kramer, Michal Perpinial, Nofar Schottlender, Stav Rabani, Keren David, Anna Wiener, Hadas Lewinsky, Shirly Becker-Herman, Rina Aharoni, Ron Milo, Claudia Mauri, Idit Shachar
Summary: Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10(+) Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmunity, thereby hinting SLAMF5 as a potential target for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Stephanie A. Amici, Wissam Osman, Mireia Guerau-de-Arellano
Summary: This study found that PRMT5 promotes G1/S cell cycle progression and is associated with disease severity in an animal model of multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Alba Sanchez-Fernandez, Stephanie Zandee, Jesus Amo-Aparicio, Marc Charabati, Alexandre Prat, Cecilia Garlanda, Elan Z. Eisenmesser, Charles A. Dinarello, Ruben Lopez-Vales
Summary: This study demonstrates that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1-R8. Administration of recombinant human IL-37 exerts therapeutic actions in EAE mice, but IL-37 transcripts are not up-regulated in peripheral blood mononuclear cells and brain lesions of MS patients.
Article
Multidisciplinary Sciences
Anett Mazlo, Ramona Kovacs, Noemi Miltner, Marta Toth, Zoltan Vereb, Krisztina Szabo, Ildiko Bacskai, Kitti Pazmandi, Agota Apati, Tamas Biro, Krisztian Bene, Eva Rajnavolgyi, Attila Bacsi
Summary: Findings suggest that MSCl cells promote differentiation of CTLA-4 expressing DCs through the production of all-trans retinoic acid, leading to the activation and polarization of allogeneic, naive T cells by semi-matured DCs in a CTLA-4 dependent manner. Understanding the molecular mechanisms behind MSC-mediated modulation of DC differentiation may expand the clinical application of MSCs in cell-free therapies.
Article
Multidisciplinary Sciences
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Summary: Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. beta-nicotinamide mononucleotide (beta-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.
NATURE COMMUNICATIONS
(2022)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Steven C. Wilson, Nathanael A. Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M. Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K. Christopher Garcia
Summary: The IL-17 family of cytokines and receptors play crucial roles in host defence and inflammatory diseases. The IL-25-IL-17RB-IL-17RA ternary complex is a C2-symmetric complex, where IL-25 interacts with IL-17RB and two 'wing-like' IL-17RA co-receptors to initiate signal transduction through a 'tip-to-tip' geometry.
Review
Oncology
Farhad Seif, Zahra Torki, Hamidreza Zalpoor, Mehran Habibi, Majid Pornour
Summary: T cells play a crucial role in tumor development and anti-tumor responses in breast cancer patients. The cytokines in the tumor microenvironment can influence the differentiation and function of T cells, thereby affecting breast cancer treatment. This review discusses the factors that affect T cell differentiation in breast cancer, as well as the related clinical trials.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Chemistry, Multidisciplinary
Tae Woo Kim, Yujin Kim, Wonsik Jung, Dong Eon Kim, Hyeongseop Keum, Youngju Son, Sangyong Jon
Summary: BRNPs have shown potential in delaying disease onset, suppressing disease progression and severity, and reducing disease incidence rate in the EAE mouse model, without the need for systemic immunosuppression. Studies have found that BRNPs negatively regulate the differentiation of naive CD4(+) T cells into Th17 cells by scavenging reactive oxygen species.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Marla C. Glass, David R. Glass, John-Paul Oliveria, Berenice Mbiribindi, Carlos O. Esquivel, Sheri M. Krams, Sean C. Bendall, Olivia M. Martinez
Summary: Regulatory B cells (Bregs) secrete interleukin-10 (IL-10) to suppress immune responses, but there is no definitive immunophenotype to identify these B cells. Multiple functional subsets of B cells can produce IL-10, and there is no unique phenotype for IL-10(+) B cells. Furthermore, a significant portion of IL-10(+) B cells also express the pro-inflammatory cytokines IL-6 and tumor necrosis factor alpha (TNF-alpha). However, operationally tolerant liver transplant recipients have an enrichment of IL-10(+) but not TNF-alpha(+) or IL-6(+) B cells compared to those receiving immunosuppression. Therefore, IL-10-producing B cells in humans constitute an induced and transient state arising from various subsets of B cells, which may contribute to the maintenance of immune homeostasis.
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Justin Cruz, Michael A. Irvine, Vishal Avinashi, Edmond S. Chan, Bruce A. Vallance, Lianne Soller, Jonathan W. Bush
Summary: The study aimed to validate and apply the EoEHSS for predicting symptoms and endoscopy response in eosinophilic esophagitis (EoE). The results showed that almost all EoEHSS variables were significantly associated with active EoE and high PEC, with basal zone hyperplasia, eosinophil abscesses, and surface epithelial alteration being the most predictive features for identifying active EoE.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Williams Turpin, Mei Dong, Gila Sasson, Juan Antonio Raygoza Garay, Osvaldo Espin-Garcia, Sun-Ho Lee, Anna Neustaeter, Michelle Smith, Haim Leibovitzh, David S. Guttman, Ashleigh Goethel, Anne M. Griffiths, Hien Q. Huynh, Levinus A. Dieleman, Remo Panaccione, A. Hillary Steinhart, Mark S. Silverberg, Guy Aumais, Kevan Jacobson, David Mack, Sanjay K. Murthy, John K. Marshall, Charles N. Bernstein, Maria T. Abreu, Paul Moayyedi, Andrew D. Paterson, Wei Xu, Kenneth Croitoru
Summary: Mediterranean-like dietary patterns are associated with specific gut microbial compositions and lower levels of intestinal inflammation.
Article
Immunology
Carlene L. Zindl, Steven J. Witte, Vincent A. Laufer, Min Gao, Zongliang Yue, Karen M. Janowski, Baiyi Cai, Blake F. Frey, Daniel J. Silberger, Stacey N. Harbour, Jeffrey R. Singer, Henrietta Turner, Frances E. Lund, Bruce A. Vallance, Alexander F. Rosenberg, Trenton R. Schoeb, Jake Y. Chen, Robin D. Hatton, Casey T. Weaver
Summary: IL-22 produced by ILCs and T cells plays different roles in immune defense against Citrobacter rodentium infection. ILC-derived IL-22 temporarily restrains bacterial growth, while T cell-derived IL-22 protects the intestinal crypts by inducing a host-protective transcriptomic program.
Article
Pediatrics
Amanda S. Nitschke, Jalisa L. Karim, Bruce A. Vallance, Celeste Bickford, Angie Ip, Nancy Lanphear, Bruce Lanphear, Whitney Weikum, Tim F. Oberlander, Gillian E. Hanley
Summary: Research findings suggest that the use of antibiotics during labor and delivery is not associated with an increased risk of autism spectrum disorder in offspring. This indicates that concerns about autism should not influence the decision to administer antibiotics during labor and delivery.
Article
Gastroenterology & Hepatology
Torsten P. M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek Dai, Caixia Ma, Stefan R. Havik, Manon Balvers, Mark Davids, Abraham S. Meijnikman, Omrum Aydin, Bert-Jan H. Van den Born, Marc G. Besselink, Olivier R. Busch, Maurits de Brauw, Arnold van de Laar, Clara Belzer, Martin Stahl, Willem M. de Vos, Bruce A. Vallance, Max Nieuwdorp, C. Bruce Verchere, Daniel H. van Raalte
Summary: This study found that flagellin, which is more abundant in the gut of individuals with T2D, induces an inflammatory response in pancreatic islets and leads to beta-cell dysfunction, suggesting it as a potential therapeutic target for T2D.
Article
Gastroenterology & Hepatology
Kevin Tsai, Caixia Ma, Xiao Han, Joannie Allaire, Genelle R. Lunken, Shauna M. Crowley, Hongbing Yu, Kevan Jacobson, Lijun Xia, John J. Priatel, Bruce A. Vallance
Summary: This article introduces a flow cytometry-based method of measuring intestinal permeability. By detecting orally gavaged ovalbumin (OVA) leaking from the gut and using minute blood samples collected from the tail vein, it allows for repeated testing of the same animal at multiple time points to measure intestinal permeability. The OVA assay shows high sensitivity and effectiveness compared to current methods.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjie Shi, Kaixin Peng, Hongbing Yu, Zi Wang, Shuhong Xia, Siqi Xiao, Dean Tian, Bruce A. Vallance, Qin Yu
Summary: Inflammatory bowel disease (IBD) is an immune-mediated disease. Autotaxin (ATX) is associated with increased inflammatory molecules, however, its effect on IBD is not well understood. This study aimed to explore the possible mechanisms of ATX affecting autophagy leading to the disruption of intestinal epithelial barrier, thereby exacerbating colitis. The results showed that ATX can inhibit autophagy through the mTOR pathway, resulting in exaggerated damage to the intestinal epithelial barrier during colitis. These findings suggest that ATX may be a key pro-colitic factor, and represent a potential therapeutic target for treating IBD in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Gastroenterology & Hepatology
Alexandra E. Livanos, Alexandra Dunn, Jeremy Fischer, Ryan C. Ungaro, Williams Turpin, Sun -Ho Lee, Shumin Rui, Diane Marie Del Valle, Julia J. Jougon, Gustavo Martinez-Delgado, Mark S. Riddle, Joseph A. Murray, Renee M. Laird, Joana Torres, Manasi Agrawal, Jared S. Magee, Thierry Dervieux, Sacha Gnjatic, Dean Sheppard, Bruce E. Sands, Chad K. Poster, Kenneth Croitoru, Francesca Petralia, Jean-Frederic Colombel, Saurabh Mehandru
Summary: This study found that anti-integrin avfi6 autoantibodies are present in patients with ulcerative colitis (UC) and are associated with disease development and outcomes before diagnosis. These findings suggest that anti-avfi6 antibodies may be a useful biomarker for prediction and prognosis of UC.
Article
Medicine, Research & Experimental
Catherine M. Biggs, Anna Cordeiro-Santanach, Sergey V. Prykhozhij, Adam P. Deveau, Yi Lin, Kate L. Bel, Felix Orben, Robert J. Ragotte, Aabida Saferali, Sara Mostafavi, Louie Dinh, Darlene Dai, Katja G. Weinacht, Kerry Dobbs, Lisa Ott de Bruin, Mehul Sharma, Kevin Tsai, John J. Priatel, Richard A. Schreiber, Jacob Rozmus, Martin C. K. Hosking, Kevin E. Shopsowitz, Margaret L. McKinnon, Suzanne Vercauteren, Michael Seear, Luigi D. Notarangelo, Francis C. Lynn, Jason N. Berman, Stuart E. Turvey
Summary: This study identifies the role of JAK1 gene mutations in severe atopic disorders and eosinophilia, and reveals the involvement of JAK1 signaling in atopic immune dysregulation. Additionally, long-term treatment with JAK1/2 inhibitors significantly improves growth, eosinophilia, and clinical symptoms of allergic inflammation in patients.
Article
Gastroenterology & Hepatology
Juan Antonio Raygoza Garay, Williams Turpin, Sun-Ho Lee, Michelle I. Smith, Ashleigh Goethel, Anne M. Griffiths, Paul Moayyedi, Osvaldo Espin-Garcia, Maria Abreu, Guy L. Aumais, Charles N. Bernstein, Irit A. Biron, Maria Cino, Colette Deslandres, Iris Dotan, Wael El-Matary, Brian Feagan, David S. Guttman, Hien Huynh, Levinus A. Dieleman, Jeffrey S. Hyams, Kevan Jacobson, David Mack, John K. Marshall, Anthony Otley, Remo Panaccione, Mark Ropeleski, Mark S. Silverberg, A. Hillary Steinhart, Dan Turner, Baruch Yerushalmi, Andrew D. Paterson, Kenneth Croitoru, W. Xu
Summary: This study is the first to demonstrate that gut microbiome composition is associated with the future onset of Crohn's disease (CD), suggesting that gut microbiome is a contributor in the pathogenesis of CD.
Article
Clinical Neurology
Sung -Pin Fan, Yih-Chih Kuo, Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu, Yu-Hsuan Huang, Han- Lin, Tai -Chung Tseng, Tung -Hung Su, Shiou-Ru Tzeng, Chien -Ting Hsu, Huey -Ling Chen, Chin-Hsien Lin, Yen-Hsuan Ni
Summary: In this retrospective analysis, the clinical characteristics and long-term outcomes of a large cohort of WD patients were determined. Differences were observed between the neuro-psychiatric group and the hepatic group in terms of presentation, neuroimaging, genetic information, and prognosis. The findings suggest that the clinical characteristics and prognosis of WD are influenced by ethnic differences.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Qiaochu Liang, Caixia Ma, Shauna M. Crowley, Joannie M. Allaire, Xiao Han, Raymond W. W. Chong, Nicolle H. Packer, Hong Bing Yu, Bruce A. Vallance
Summary: Enteric bacterial pathogens, such as Citrobacter rodentium, are able to adapt to the host's intestinal environment through metabolizing sialic acid derived from mucins and utilizing it as a carbon source for growth. The bacteria also sense and display chemotactic activity toward sialic acid. Sialic acid induces the secretion of autotransporter proteins, Pic and EspC, which enhance the bacteria's ability to degrade intestinal mucus and adhere to epithelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Israel Matos, Maunish Barvalia, Manreet K. Chehal, A. Gordon Robertson, Iva Kulic, Jessica A. F. D. Silva, Abhinandan Ranganathan, Amy Short, Yu-Hsuan Huang, Erin Long, John J. Priatel, Salim Dhanji, Brad H. Nelson, Danielle L. Krebs, Kenneth W. Harder
Summary: While immunotherapies have improved survival for some cancer patients, many fail to respond. Tumor-derived GCSF alters myeloid cell distribution and is associated with immune cell dysregulation and decreased effectiveness of T-cell adoptive cell therapy. Normalizing GCSF bioactivity may improve immunotherapy in cancers with GCSF overexpression.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)