An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control

Differential role of cytosolic Hsp70s in longevity assurance and protein quality control

(2021) Rebecca Andersson et al.   PLoS Genetics

HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson’s Disease and Dementia with Lewy Bodies

(2019) Anastasiia Bohush et al.   Journal of Parkinsons Disease

Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress

(2019) Roja Babazadeh et al.   Cell Reports

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

(2019) Chi-ting Ho et al.   Nature Communications

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

The Plasticity of the Hsp90 Co-chaperone System

(2017) Priyanka Sahasrabudhe et al.   MOLECULAR CELL

Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c

(2017) Chueh-Ling Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

With the Help of MOM: Mitochondrial Contributions to Cellular Quality Control

(2017) Ralf J. Braun et al.   TRENDS IN CELL BIOLOGY

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network

(2017) Matej Usaj et al.   G3-Genes Genomes Genetics

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

(2017) Lindsey B. Shelton et al.   Frontiers in Neuroscience

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanisms of Hsp90 regulation

(2016) C. Prodromou   BIOCHEMICAL JOURNAL

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins

(2016) Sarah Hanzén et al.   CELL

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions

(2016) Sandra Malmgren Hill et al.   Cell Reports

Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility

(2016) Sophie A. Comyn et al.   PLoS Genetics

Systematic Functional Annotation and Visualization of Biological Networks

(2016) Anastasia Baryshnikova   Cell Systems

A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae

(2016) Lei Zhao et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

(2015) S. B. Miller et al.   EMBO JOURNAL

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy

(2015) Stephanie B.M. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

(2015) Holger Franken et al.   Nature Protocols

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase

(2015) Ingo Amm et al.   PLoS One

Protein aggregates are associated with replicative aging without compromising protein quality control

(2015) Juha Saarikangas et al.   eLife

Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance

(2014) D. Oling et al.   EMBO JOURNAL

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

(2014) M. Ogrodnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei

(2014) Johanna L Höög et al.   eLife

Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system

(2013) Ingo Amm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

(2013) Katie J. Wolfe et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens

(2013) Omar Wagih et al.   NUCLEIC ACIDS RESEARCH

Improved Blue, Green, and Red Fluorescent Protein Tagging Vectors for S. cerevisiae

(2013) Sidae Lee et al.   PLoS One

A Network of Ubiquitin Ligases Is Important for the Dynamics of Misfolded Protein Aggregates in Yeast

(2012) Maria A. Theodoraki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast

(2012) Rachel Spokoini et al.   Cell Reports

The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation

(2012) Farzin Khosrow-Khavar et al.   G3-Genes Genomes Genetics

MSnbase-an R/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation

(2011) Laurent Gatto et al.   BIOINFORMATICS

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

(2010) Sabrina Büttner et al.   PLoS One

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

NLR sensors meet at the SGT1–HSP90 crossroad

(2010) Yasuhiro Kadota et al.   TRENDS IN BIOCHEMICAL SCIENCES

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

(2009) Cheuk Hei Ho et al.   NATURE BIOTECHNOLOGY

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

(2009) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Ubiquitin Ligase Hul5 Is Required for Fragment-specific Substrate Degradation in Endoplasmic Reticulum-associated Degradation

(2008) Sonja Kohlmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sgt1 Dimerization Is Required for Yeast Kinetochore Assembly

(2008) Parmil K. Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitylation of Histone H2B

(2008) Fuqiang Geng et al.   MOLECULAR BIOLOGY OF THE CELL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE