Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

Characterization of Dynamic UbR-Proteasome Subcomplexes byIn vivoCross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation

(2016) Clinton Yu et al.   MOLECULAR & CELLULAR PROTEOMICS

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

(2016) Byung-Hoon Lee et al.   NATURE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

(2016) Nancy N. Fang et al.   Nature Communications

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

(2015) Jada H Vaden et al.   Molecular Neurodegeneration

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of the interaction of Ubp6 with the 26S proteasome

(2015) Antje Aufderheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular census of 26S proteasomes in intact neurons

(2015) S. Asano et al.   SCIENCE

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

(2015) Daichao Xu et al.   eLife

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

(2014) H. C. Besche et al.   EMBO JOURNAL

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

(2014) P. Unverdorben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Architecture and Assembly of the Eukaryotic Proteasome

(2013) Robert J. Tomko et al.   Annual Review of Biochemistry

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

(2013) Bernard W. Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs

(2013) Andreas Peth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of proteasome inhibitors as research tools and cancer drugs

(2012) Alfred L. Goldberg   JOURNAL OF CELL BIOLOGY

An Early Onset Progressive Motor Neuron Disorder in Scyl1-Deficient Mice Is Associated with Mislocalization of TDP-43

(2012) S. Pelletier et al.   JOURNAL OF NEUROSCIENCE

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation

(2010) Andreas Peth et al.   MOLECULAR CELL

Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

(2010) Kianoush Sadre-Bazzaz et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Isolation of Mammalian 26S Proteasomes and p97/VCP Complexes Using the Ubiquitin-like Domain from HHR23B Reveals Novel Proteasome-Associated Proteins†

(2009) Henrike C. Besche et al.   BIOCHEMISTRY

The Proteasome-Associated Deubiquitinating Enzyme Usp14 Is Essential for the Maintenance of Synaptic Ubiquitin Levels and the Development of Neuromuscular Junctions

(2009) P.-C. Chen et al.   JOURNAL OF NEUROSCIENCE

The Ubiquitin Ligase Hul5 Promotes Proteasomal Processivity

(2009) S. Aviram et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitinated Proteins Activate the Proteasome by Binding to Usp14/Ubp6, which Causes 20S Gate Opening

(2009) Andreas Peth et al.   MOLECULAR CELL

Thymoproteasome: probable role in generating positively selecting peptides

(2008) Shigeo Murata et al.   CURRENT OPINION IN IMMUNOLOGY

Ubiquitin Ligase Hul5 Is Required for Fragment-specific Substrate Degradation in Endoplasmic Reticulum-associated Degradation

(2008) Sonja Kohlmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome

(2007) Elena Koulich et al.   MOLECULAR BIOLOGY OF THE CELL