Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex

A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient

(2021) David Lebeaux et al.   Viruses-Basel

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

(2021) Fernando Gordillo Altamirano et al.   Nature Microbiology

Aztreonam Lysine Increases the Activity of Phages E79 and phiKZ against Pseudomonas aeruginosa PA01

(2021) Carly M. Davis et al.   Microorganisms

Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258

(2021) Shayla Hesse et al.   mBio

A Novel Inducible Prophage from Burkholderia Vietnamiensis G4 is Widely Distributed across the Species and Has Lytic Activity against Pathogenic Burkholderia

(2020) Rebecca Weiser et al.   Viruses-Basel

Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity

(2020) Edison J Cano et al.   CLINICAL INFECTIOUS DISEASES

Bacteriophage Interactions with Mammalian Tissue: Therapeutic Applications

(2019) Haein Huh et al.   ADVANCED DRUG DELIVERY REVIEWS

Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

(2019) Nancy Law et al.   INFECTION

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Evolution of Superinfection Immunity in Cluster A Mycobacteriophages

(2019) Travis N. Mavrich et al.   mBio

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

(2019) Kevin Yehl et al.   CELL

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy

(2019) Anca M Segall et al.   CURRENT OPINION IN MICROBIOLOGY

Indole-3-Acetic Acid in Burkholderia pyrrocinia JK-SH007: Enzymatic Identification of the Indole-3-Acetamide Synthesis Pathway

(2019) Wan-Hui Liu et al.   Frontiers in Microbiology

Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models

(2018) Francesca Forti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Piperacillin and ceftazidime produce the strongest synergistic phage–antibiotic effect in Pseudomonas aeruginosa

(2018) Jumpei Uchiyama et al.   ARCHIVES OF VIROLOGY

Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils

(2018) Pablo Martina et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Contribution of the Immune Response to Phage Therapy

(2018) Oleg Krut et al.   JOURNAL OF IMMUNOLOGY

Burkholderia cenocepacia Prophages—Prevalence, Chromosome Location and Major Genes Involved

(2018) Bartosz Roszniowski et al.   Viruses-Basel

Identification and Characterization of Type IV Pili as the Cellular Receptor of Broad Host Range Stenotrophomonas maltophilia Bacteriophages DLP1 and DLP2

(2018) Jaclyn McCutcheon et al.   Viruses-Basel

Does Treatment Order Matter? Investigating the Ability of Bacteriophage to Augment Antibiotic Activity against Staphylococcus aureus Biofilms

(2018) Dilini Kumaran et al.   Frontiers in Microbiology

Phage-Antibiotic Synergy via Delayed Lysis

(2018) Minjin Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced antibacterial effect of the novel T4-like bacteriophage KARL-1 in combination with antibiotics against multi-drug resistant Acinetobacter baumannii

(2018) Mathias Jansen et al.   Scientific Reports

Synergistic effect of phage therapy using a cocktail rather than a single phage in the control of severe colibacillosis in quails

(2018) Mohammad Naghizadeh et al.   POULTRY SCIENCE

Phage Therapy: Going Temperate?

(2018) Rodrigo Monteiro et al.   TRENDS IN MICROBIOLOGY

A bacteriophages journey through the human body

(2017) Jeremy J. Barr   IMMUNOLOGICAL REVIEWS

Lysogeny in nature: mechanisms, impact and ecology of temperate phages

(2017) Cristina Howard-Varona et al.   ISME Journal

Volcanic Soils as Sources of Novel CO-Oxidizing Paraburkholderia and Burkholderia: Paraburkholderia hiiakae sp. nov., Paraburkholderia metrosideri sp. nov., Paraburkholderia paradisi sp. nov., Paraburkholderia peleae sp. nov., and Burkholderia alpina sp. nov. a Member of the Burkholderia cepacia Complex

(2017) Carolyn F. Weber et al.   Frontiers in Microbiology

Detection of misidentifications of species from the Burkholderia cepacia complex and description of a new member, the soil bacterium Burkholderia catarinensis sp. nov.

(2017) Evelise Bach et al.   Pathogens and Disease

Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy

(2017) C. Duplessis et al.   Journal of the Pediatric Infectious Diseases Society

Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections

(2016) James M. Regeimbal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage-encoded depolymerases: their diversity and biotechnological applications

(2016) Diana P. Pires et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Burkholderia: an update on taxonomy and biotechnological potential as antibiotic producers

(2016) Eliza Depoorter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The temperate Burkholderia phage AP3 of the Peduovirinae shows efficient antimicrobial activity against B. cenocepacia of the IIIA lineage

(2016) Bartosz Roszniowski et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

(2016) Samuel T. Montgomery et al.   EUROPEAN RESPIRATORY JOURNAL

Bacteriophages and its applications: an overview

(2016) Sonika Sharma et al.   FOLIA MICROBIOLOGICA

Synergistic interaction between phage therapy and antibiotics clears Pseudomonas aeruginosa infection in endocarditis and reduces virulence

(2016) Frank Oechslin et al.   JOURNAL OF INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

The mathematics of random mutation and natural selection for multiple simultaneous selection pressures and the evolution of antimicrobial drug resistance

(2016) Alan Kleinman   STATISTICS IN MEDICINE

Evolutionary Rationale for Phages as Complements of Antibiotics

(2016) Clara Torres-Barceló et al.   TRENDS IN MICROBIOLOGY

Intrinsic Resistance of Burkholderia cepacia Complex to Benzalkonium Chloride

(2016) Youngbeom Ahn et al.   mBio

P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality

(2016) Erin A. Ronayne et al.   PLoS Genetics

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy

(2016) Maciej Żaczek et al.   Frontiers in Microbiology

Burkholderia paludis sp. nov., an Antibiotic-Siderophore Producing Novel Burkholderia cepacia Complex Species, Isolated from Malaysian Tropical Peat Swamp Soil

(2016) Kuan Shion Ong et al.   Frontiers in Microbiology

Bacteriophage treatment of intransigent diabetic toe ulcers: a case series

(2016) R. Fish et al.   Journal of Wound Care

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The isolation and characterization of two Stenotrophomonas maltophilia bacteriophages capable of cross-taxonomic order infectivity

(2015) Danielle L. Peters et al.   BMC GENOMICS

Burkholderia stagnalis sp. nov. and Burkholderia territorii sp. nov., two novel Burkholderia cepacia complex species from environmental and human sources

(2015) Birgit De Smet et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

A century of the phage: past, present and future

(2015) George P. C. Salmond et al.   NATURE REVIEWS MICROBIOLOGY

Phage selection for bacterial cheats leads to population decline

(2015) Marie Vasse et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phage therapy redux--What is to be done?

(2015) R. Young et al.   SCIENCE

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Efflux pump-mediated drug resistance in Burkholderia

(2015) Nicole L. Podnecky et al.   Frontiers in Microbiology

Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm

(2015) Katarzyna Danis-Wlodarczyk et al.   PLoS One

Longevity of Patients With Cystic Fibrosis in 2000 to 2010 and Beyond: Survival Analysis of the Cystic Fibrosis Foundation Patient Registry

(2014) Todd MacKenzie et al.   ANNALS OF INTERNAL MEDICINE

Aerosol Phage Therapy Efficacy in Burkholderia cepacia Complex Respiratory Infections

(2014) Diana D. Semler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Burkholderia cepacia Complex Phage-Antibiotic Synergy (PAS): Antibiotics Stimulate Lytic Phage Activity

(2014) Fatima Kamal et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A century of phage research: Bacteriophages and the shaping of modern biology

(2014) Eric C. Keen   BIOESSAYS

Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections

(2014) Chloe E James et al.   ISME Journal

The Contribution of Antibiotic Resistance Mechanisms in Clinical Burkholderia cepacia Complex Isolates: An Emphasis on Efflux Pump Activity

(2014) Sung-Pin Tseng et al.   PLoS One

Phage Neutralization by Sera of Patients Receiving Phage Therapy

(2014) Marzanna Łusiak-Szelachowska et al.   VIRAL IMMUNOLOGY

Clostridium difficile phages: still difficult?

(2014) Katherine R. Hargreaves et al.   Frontiers in Microbiology

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial

(2014) D.D. Rhoads et al.   Journal of Wound Care

Phage-induced diversification improves host evolvability

(2013) Hywel TP Williams   BMC EVOLUTIONARY BIOLOGY

Genomic characterization of JG068, a novel virulent podovirus active against Burkholderia cenocepacia

(2013) Karlene H Lynch et al.   BMC GENOMICS

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Antibiotics in the clinical pipeline in 2013

(2013) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

T4 Phage and Its Head Surface Proteins Do Not Stimulate Inflammatory Mediator Production

(2013) Paulina Miernikiewicz et al.   PLoS One

Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

(2013) Shawna McCallin et al.   VIROLOGY

Methicillin-Resistant Staphylococcus aureus Phage Plaque Size Enhancement Using Sublethal Concentrations of Antibiotics

(2012) Sandeep Kaur et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effects of Sequential and Simultaneous Applications of Bacteriophages on Populations of Pseudomonas aeruginosaIn Vitroand in Wax Moth Larvae

(2012) Alex R. Hall et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages

(2012) Karlene H Lynch et al.   BMC GENOMICS

Synergistic phage-antibiotic combinations for the control ofEscherichia colibiofilmsin vitro

(2012) Elizabeth M. Ryan et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Modelling Co-Infection of the Cystic Fibrosis Lung by Pseudomonas aeruginosa and Burkholderia cenocepacia Reveals Influences on Biofilm Formation and Host Response

(2012) Alessandra Bragonzi et al.   PLoS One

Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

(2012) Shafiqul Alam Sarker et al.   VIROLOGY

The Promise of Bacteriophage Therapy for Burkholderia cepacia Complex Respiratory Infections

(2012) Diana D. Semler et al.   Frontiers in Cellular and Infection Microbiology

Characterization of DC1, a Broad-Host-Range Bcep22-Like Podovirus

(2011) Karlene H. Lynch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genomes and Characterization of Phages Bcep22 and BcepIL02, Founders of a Novel Phage Type in Burkholderia cenocepacia

(2011) J. J. Gill et al.   JOURNAL OF BACTERIOLOGY

Spray-dried Respirable Powders Containing Bacteriophages for the Treatment of Pulmonary Infections

(2011) Sadaf Matinkhoo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Deciphering the Role of RND Efflux Transporters in Burkholderia cenocepacia

(2011) Silvia Bazzini et al.   PLoS One

Bacteriophage-Resistant Mutants in Yersinia pestis: Identification of Phage Receptors and Attenuation for Mice

(2011) Andrey A. Filippov et al.   PLoS One

Bacteriophages and their genomes

(2011) Graham F Hatfull et al.   Current Opinion in Virology

Extreme antimicrobial peptide and polymyxin B resistance in the genus Burkholderia

(2011) Slade Loutet   Frontiers in Cellular and Infection Microbiology

Insights into the role of extracellular polysaccharides in Burkholderia adaptation to different environments

(2011) Ana S. Ferreira   Frontiers in Cellular and Infection Microbiology

Evaluation of lytic activity of staphylococcal bacteriophage Sb-1 against freshly isolated clinical pathogens

(2011) Leila Kvachadze et al.   Microbial Biotechnology

The phage-host arms race: Shaping the evolution of microbes

(2010) Adi Stern et al.   BIOESSAYS

Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complex

(2010) Karlene H Lynch et al.   BMC GENOMICS

The Changing Microbial Epidemiology in Cystic Fibrosis

(2010) J. J. LiPuma   CLINICAL MICROBIOLOGY REVIEWS

Efficacy of Polyvalent Bacteriophage P-27/HP to Control Multidrug Resistant Staphylococcus aureus Associated with Human Infections

(2010) Ragini Gupta et al.   CURRENT MICROBIOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

In vitro lung delivery of bacteriophages KS4-M and ΦKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosis

(2010) L. Golshahi et al.   JOURNAL OF APPLIED MICROBIOLOGY

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriophages as potential new therapeutics to replace or supplement antibiotics

(2010) Mzia Kutateladze et al.   TRENDS IN BIOTECHNOLOGY

Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy

(2010) Geraint B. Rogers et al.   TRENDS IN MICROBIOLOGY

Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex

(2009) K. D. Seed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

(2009) Silvia Buroni et al.   BMC MICROBIOLOGY

Bacteriophage interactions with phagocytes and their potential significance in experimental therapy

(2009) Aneta Kurzępa et al.   CLINICAL AND EXPERIMENTAL MEDICINE

RecurrentBurkholderiaInfection in Patients with Chronic Granulomatous Disease: 11‐Year Experience at a Large Referral Center

(2009) David E. Greenberg et al.   CLINICAL INFECTIOUS DISEASES

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria

(2009) E. Peeters et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Involvement of Two Transport Systems and a Specific Porin in the Uptake of Phthalate by Burkholderia spp.

(2009) H.-K. Chang et al.   JOURNAL OF BACTERIOLOGY

Efficacy of Bacteriophage Therapy in a Model ofBurkholderia cenocepaciaPulmonary Infection

(2009) Lisa A. Carmody et al.   JOURNAL OF INFECTIOUS DISEASES

Inactivation of Burkholderia cepacia Complex Phage KS9 gp41 Identifies the Phage Repressor and Generates Lytic Virions

(2009) K. H. Lynch et al.   JOURNAL OF VIROLOGY

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET

Burkholderia glumaeandB. gladioliCause Bacterial Panicle Blight in Rice in the Southern United States

(2009) Rangaraj Nandakumar et al.   PLANT DISEASE

Quality-Controlled Small-Scale Production of a Well-Defined Bacteriophage Cocktail for Use in Human Clinical Trials

(2009) Maya Merabishvili et al.   PLoS One

Chronic Granulomatous Disease: The European Experience

(2009) J. Merlijn van den Berg et al.   PLoS One

Survey of infection control policies for patients with cystic fibrosis in the United States

(2008) Juyan Zhou et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex

(2008) Amanda D Goudie et al.   BMC GENOMICS

Development of Galleria mellonella as an Alternative Infection Model for the Burkholderia cepacia Complex

(2008) K. D. Seed et al.   INFECTION AND IMMUNITY

Toward Modern Inhalational Bacteriophage Therapy: Nebulization of Bacteriophages of Burkholderia cepacia Complex

(2008) Laleh Golshahi et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology

(2008) E. Mahenthiralingam et al.   JOURNAL OF APPLIED MICROBIOLOGY

The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients

(2008) M. T. G. Holden et al.   JOURNAL OF BACTERIOLOGY