Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages

Cangene Gold Medal Award Lecture — Genomic analysis and modification of Burkholderia cepacia complex bacteriophages1This article is based on a presentation by Dr. Karlene Lynch at the 61st Annual Meeting of the Canadian Society of Microbiologists in St. John’s, Newfoundland and Labrador, on 21 June 2011. Dr. Lynch was the recipient of the 2011 Cangene Gold Medal as the Canadian Graduate Student Microbiologist of the Year, an annual award sponsored by Cangene Corporation intended to recognize excellence in graduate research.

(2012) Karlene H. Lynch et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Characterization of DC1, a Broad-Host-Range Bcep22-Like Podovirus

(2011) Karlene H. Lynch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genomes and Characterization of Phages Bcep22 and BcepIL02, Founders of a Novel Phage Type in Burkholderia cenocepacia

(2011) J. J. Gill et al.   JOURNAL OF BACTERIOLOGY

Spray-dried Respirable Powders Containing Bacteriophages for the Treatment of Pulmonary Infections

(2011) Sadaf Matinkhoo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pulmonary Bacteriophage Therapy on Pseudomonas aeruginosa Cystic Fibrosis Strains: First Steps Towards Treatment and Prevention

(2011) Eric Morello et al.   PLoS One

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

Phenotypic and genotypic variations within a single bacteriophage species

(2011) Pieter-Jan Ceyssens et al.   Virology Journal

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantification of Shiga Toxin-Converting Bacteriophages in Wastewater and in Fecal Samples by Real-Time Quantitative PCR

(2010) L. Imamovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complex

(2010) Karlene H Lynch et al.   BMC GENOMICS

The in vivo efficacy of two administration routes of a phage cocktail to reduce numbers of Campylobacter coli and Campylobacter jejuni in chickens

(2010) Carla M Carvalho et al.   BMC MICROBIOLOGY

Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments

(2010) Matthew B. Sullivan et al.   ENVIRONMENTAL MICROBIOLOGY

Ecogenomics and genome landscapes of marine Pseudoalteromonas phage H105/1

(2010) Melissa Beth Duhaime et al.   ISME Journal

In vitro lung delivery of bacteriophages KS4-M and ΦKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosis

(2010) L. Golshahi et al.   JOURNAL OF APPLIED MICROBIOLOGY

The Stringent Response Is Required for Full Virulence ofMycobacterium tuberculosisin Guinea Pigs

(2010) Lee G. Klinkenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055

(2010) S. Kumari et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs

(2010) Anne Lopes et al.   NUCLEIC ACIDS RESEARCH

Analysis of High-Throughput Sequencing and Annotation Strategies for Phage Genomes

(2010) Matthew R. Henn et al.   PLoS One

Orally Administered P22 Phage Tailspike Protein Reduces Salmonella Colonization in Chickens: Prospects of a Novel Therapy against Bacterial Infections

(2010) Shakeeba Waseh et al.   PLoS One

In vivo efficiency evaluation of a phage cocktail in controlling severe colibacillosis in confined conditions and experimental poultry houses

(2010) Ana Oliveira et al.   VETERINARY MICROBIOLOGY

Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex

(2009) K. D. Seed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Genomic analysis of multiple Roseophage SIO1 strains

(2009) Florent Angly et al.   ENVIRONMENTAL MICROBIOLOGY

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Biosynthesis and Structure of theBurkholderia cenocepaciaK56-2 Lipopolysaccharide Core Oligosaccharide

(2009) Ximena Ortega et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of Bacteriophage Therapy in a Model ofBurkholderia cenocepaciaPulmonary Infection

(2009) Lisa A. Carmody et al.   JOURNAL OF INFECTIOUS DISEASES

Inactivation of Burkholderia cepacia Complex Phage KS9 gp41 Identifies the Phage Repressor and Generates Lytic Virions

(2009) K. H. Lynch et al.   JOURNAL OF VIROLOGY

Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex

(2008) Amanda D Goudie et al.   BMC GENOMICS

Toward Modern Inhalational Bacteriophage Therapy: Nebulization of Bacteriophages of Burkholderia cepacia Complex

(2008) Laleh Golshahi et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Salmonella enterica Serovar Gallinarum Requires ppGpp for Internalization and Survival in Animal Cells

(2008) J.-H. Jeong et al.   JOURNAL OF BACTERIOLOGY

Evidence for the Intense Exchange of MazG in Marine Cyanophages by Horizontal Gene Transfer

(2008) Michael J. Bryan et al.   PLoS One