Clostridium difficile phages: still difficult?

Characterization of Temperate Phages Infecting Clostridium difficile Isolates of Human and Animal Origins

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biogenesis and functions of bacterial S-layers

(2014) Robert P. Fagan et al.   NATURE REVIEWS MICROBIOLOGY

What Does the Talking?: Quorum Sensing Signalling Genes Discovered in a Bacteriophage Genome

(2014) Katherine R. Hargreaves et al.   PLoS One

Guidelines for Diagnosis, Treatment and Prevention of Clostridium difficile Infections

(2013) Christina M Surawicz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system

(2013) Emma Meader et al.   ANAEROBE

Genetically Diverse Clostridium difficile Strains Harboring Abundant Prophages in an Estuarine Environment

(2013) K. R. Hargreaves et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Construction of a Prophage-Free Variant of Corynebacterium glutamicum ATCC 13032 for Use as a Platform Strain for Basic Research and Industrial Biotechnology

(2013) Meike Baumgart et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Back to the future: evolving bacteriophages to increase their effectiveness against the pathogenPseudomonas aeruginosaPAO1

(2013) Alex Betts et al.   Evolutionary Applications

Novel avenues for Clostridium difficile infection drug discovery

(2013) Mario Zucca et al.   Expert Opinion on Drug Discovery

Lack of the host membrane protease FtsH hinders release of the Lactococcus lactis bacteriophage TP712

(2013) C. Roces et al.   JOURNAL OF GENERAL VIROLOGY

Impact of cleaning and other interventions on the reduction of hospital-acquired Clostridium difficile infections in two hospitals in England assessed using a breakpoint model

(2013) G.J. Hughes et al.   JOURNAL OF HOSPITAL INFECTION

Determination of the attP and attB sites of phage  CD27 from Clostridium difficile NCTC 12727

(2013) R. Williams et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Proteomic Comparison of Historic and Recently Emerged Hypervirulent Clostridium difficile Strains

(2013) Jenn-Wei Chen et al.   JOURNAL OF PROTEOME RESEARCH

Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome

(2013) Sheetal R. Modi et al.   NATURE

Genome sequence and analysis of a broad-host range lytic bacteriophage that infects the Bacillus cereus group

(2013) Tarek F El-Arabi et al.   Virology Journal

A Multifaceted Study of Pseudomonas aeruginosa Shutdown by Virulent Podovirus LUZ19

(2013) R. Lavigne et al.   mBio

Phage  C2 Mediates Transduction of Tn6215, Encoding Erythromycin Resistance, between Clostridium difficile Strains

(2013) S. Goh et al.   mBio

Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers

(2013) Michael S.M. Brouwer et al.   Nature Communications

Importance of prophages to evolution and virulence of bacterial pathogens

(2013) Louis-Charles Fortier et al.   Virulence

Exploring the risks of phage application in the environment

(2013) Sean Meaden et al.   Frontiers in Microbiology

Evidence ofIn VivoProphage Induction during Clostridium difficile Infection

(2012) Mathieu Meessen-Pinard et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prophage Carriage and Diversity within Clinically Relevant Strains of Clostridium difficile

(2012) Jinyu Shan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clostridium difficile genotypes other than ribotype 078 that are prevalent among human, animal and environmental isolates

(2012) Sandra Janezic et al.   BMC MICROBIOLOGY

Fidaxomicin Preserves the Intestinal Microbiome During and After Treatment of Clostridium difficile Infection (CDI) and Reduces Both Toxin Reexpression and Recurrence of CDI

(2012) T. J. Louie et al.   CLINICAL INFECTIOUS DISEASES

Changing Epidemiology of Clostridium difficile Infection Following the Introduction of a National Ribotyping-Based Surveillance Scheme in England

(2012) M. H. Wilcox et al.   CLINICAL INFECTIOUS DISEASES

Consequences of Clostridium difficile infection: understanding the healthcare burden

(2012) E. Bouza   CLINICAL MICROBIOLOGY AND INFECTION

Phages limit the evolution of bacterial antibiotic resistance in experimental microcosms

(2012) Quan-Guo Zhang et al.   Evolutionary Applications

Recovery of viable cyanophages from the sediments of a eutrophic lake at decadal timescales

(2012) Kate R. Hargreaves et al.   FEMS MICROBIOLOGY ECOLOGY

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

(2012) Miao He et al.   NATURE GENETICS

Molecular Characterization of Podoviral Bacteriophages Virulent for Clostridium perfringens and Their Comparison with Members of the Picovirinae

(2012) Nikolay V. Volozhantsev et al.   PLoS One

Succession in the Gut Microbiome following Antibiotic and Antibody Therapies for Clostridium difficile

(2012) Gregory L. Peterfreund et al.   PLoS One

Pseudomonas Biofilms, Cystic Fibrosis, and Phage: a Silver Lining?

(2012) H. Brussow   mBio

Clostridium difficile in seafood and fish

(2011) Devon Metcalf et al.   ANAEROBE

In vivo lysogenization of a Clostridium difficile bacteriophage ФCD119

(2011) Govind Revathi et al.   ANAEROBE

Bacteriophage-Mediated Dispersal of Campylobacter jejuni Biofilms

(2011) Patcharin Siringan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Easyfig: a genome comparison visualizer

(2011) M. J. Sullivan et al.   BIOINFORMATICS

Modified phages: Novel antimicrobial agents to combat infectious diseases

(2011) Zahra Moradpour et al.   BIOTECHNOLOGY ADVANCES

Isolation and characterization of Clostridium difficile from shellfish and marine environments

(2011) Vincenzo Pasquale et al.   FOLIA MICROBIOLOGICA

Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens

(2011) O. Sekulovic et al.   JOURNAL OF BACTERIOLOGY

Wall Teichoic Acid-Dependent Adsorption of Staphylococcal Siphovirus and Myovirus

(2011) G. Xia et al.   JOURNAL OF BACTERIOLOGY

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Clostridium difficile Mixed Infection and Reinfection: Fig 1

(2011) David W. Eyre et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291

(2011) A. M. Buckley et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Ecology drives a global network of gene exchange connecting the human microbiome

(2011) Chris S. Smillie et al.   NATURE

The costs of evolving resistance in heterogeneous parasite environments

(2011) B. Koskella et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

(2010) Emma Meader et al.   ANAEROBE

The occurrence and high diversity of Clostridium difficile genotypes in rivers

(2010) Valerija Zidaric et al.   ANAEROBE

The phage-host arms race: Shaping the evolution of microbes

(2010) Adi Stern et al.   BIOESSAYS

Genome analysis of the Clostridium difficile phage ΦCD6356, a temperate phage of the Siphoviridae family

(2010) Marianne Horgan et al.   GENE

Comparative Metagenomic Study of Alterations to the Intestinal Microbiota and Risk of NosocomialClostridum difficile–Associated Disease

(2010) Amee R. Manges et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile in vegetables, Canada

(2010) D.S. Metcalf et al.   LETTERS IN APPLIED MICROBIOLOGY

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model System

(2009) W. Fu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Classification of Myoviridae bacteriophages using protein sequence similarity

(2009) Rob Lavigne et al.   BMC MICROBIOLOGY

Bacteremia due to Clostridium difficile—review of the literature

(2009) Donice B. Libby et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Proteomic and Genomic Characterization of Highly Infectious Clostridium difficile 630 Spores

(2009) T. D. Lawley et al.   JOURNAL OF BACTERIOLOGY

Recurrent Clostridium difficile infection: A review of risk factors, treatments, and outcomes

(2009) Stuart Johnson   JOURNAL OF INFECTION

Bacteriophage-Mediated Toxin Gene Regulation in Clostridium difficile

(2009) R. Govind et al.   JOURNAL OF VIROLOGY

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

The Secret Life of the Anthrax Agent Bacillus anthracis: Bacteriophage-Mediated Ecological Adaptations

(2009) Raymond Schuch et al.   PLoS One

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

(2009) Richard A Stabler et al.   GENOME BIOLOGY

Both Oral Metronidazole and Oral Vancomycin Promote Persistent Overgrowth of Vancomycin-Resistant Enterococci during Treatment of Clostridium difficile-Associated Disease

(2008) W. N. Al-Nassir et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence ofClostridium difficileInfection Due to a New Hypervirulent Strain, Polymerase Chain Reaction Ribotype 078

(2008) Abraham Goorhuis et al.   CLINICAL INFECTIOUS DISEASES

Molecular Characterization of a Clostridium difficile Bacteriophage and Its Cloned Biologically Active Endolysin

(2008) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY