HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response
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Title
HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response
Authors
Keywords
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Journal
Viruses-Basel
Volume 13, Issue 6, Pages 1102
Publisher
MDPI AG
Online
2021-06-10
DOI
10.3390/v13061102
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Note: Only part of the references are listed.- Statins attenuate antiviral IFN‐β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)‐treated hyperlipidemic mice and macrophages
- (2021) Atsushi Koike et al. FEBS Journal
- Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation
- (2021) Cindy Chiang et al. Viruses-Basel
- Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein
- (2021) Wen Meng et al. Cell Death & Disease
- The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
- (2021) Ziyang Fu et al. Nature Communications
- EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
- (2021) Minsu Jang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of interferon-stimulated gene 15 and lysine 48-linked ubiquitin binding to the SARS-CoV-2 papain-like protease by small molecules: In silico studies
- (2021) Eleni Pitsillou et al. CHEMICAL PHYSICS LETTERS
- High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
- (2021) Yao Zhao et al. Protein & Cell
- ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
- (2021) GuanQun Liu et al. Nature Microbiology
- Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques
- (2020) Alexandra Greenberg et al. AMERICAN JOURNAL OF PATHOLOGY
- Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19
- (2020) Valentino Clemente et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
- (2020) Yaya Wang et al. JOURNAL OF CELL SCIENCE
- Impairment of the deISGylation activity of FMDV Lpro causes attenuation in vitro and in vivo
- (2020) Gisselle N. Medina et al. JOURNAL OF VIROLOGY
- Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions
- (2020) Marta Martin-Fernandez et al. Cell Reports
- ISGylation of hepatitis C virus NS5A protein promotes viral RNA replication via the recruitment of cyclophilin A
- (2020) Takayuki Abe et al. JOURNAL OF VIROLOGY
- Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
- (2020) Donghyuk Shin et al. NATURE
- Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins
- (2020) Caleb D. Swaim et al. Cell Reports
- Interferon stimulated gene 15 promotes Zika virus replication through regulating Jak/STAT and ISGylation pathways
- (2020) Yancui Wang et al. VIRUS RESEARCH
- ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells
- (2020) Jaya Bhushan et al. mBio
- ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain
- (2020) Stephanie Devignot et al. PLoS Neglected Tropical Diseases
- Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis
- (2020) John V. Dzimianski et al. Acta Crystallographica Section D-Structural Biology
- Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
- (2019) John V. Dzimianski et al. PLoS Pathogens
- Interferon-stimulated gene 15 (ISG15) restricts Zika virus replication in primary human corneal epithelial cells
- (2019) Pawan Kumar Singh et al. Ocular Surface
- E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity
- (2019) Yi Zheng et al. CELLULAR IMMUNOLOGY
- HECT E3 Ligases: A Tale With Multiple Facets
- (2019) Janine Weber et al. Frontiers in Physiology
- Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection
- (2019) Florine E. M. Scholte et al. mBio
- Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
- (2019) Shang-Ze Li et al. Nature Communications
- Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease
- (2019) Jozlyn R. Clasman et al. ANTIVIRAL RESEARCH
- The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
- (2019) Yifeng Zhang et al. Nature Communications
- Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases
- (2019) John V. Dzimianski et al. PLoS One
- Structural mechanisms of HECT-type ubiquitin ligases
- (2018) Sonja Lorenz BIOLOGICAL CHEMISTRY
- Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity
- (2018) Ermela Paparisto et al. JOURNAL OF VIROLOGY
- Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L
- (2018) Myoung Kyu Lee et al. JOURNAL OF VIROLOGY
- ISG15 in antiviral immunity and beyond
- (2018) Yi-Chieh Perng et al. NATURE REVIEWS MICROBIOLOGY
- ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia
- (2018) Piotr Przanowski et al. NEUROCHEMISTRY INTERNATIONAL
- Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
- (2018) Kirby N. Swatek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells
- (2018) Julia Hollingsworth et al. NEOPLASIA
- Overexpression of cellular telomerase RNA enhances virus-induced cancer formation
- (2018) Ahmed Kheimar et al. ONCOGENE
- Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing
- (2017) Christopher Bianco et al. JOURNAL OF VIROLOGY
- Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease
- (2017) Florine E.M. Scholte et al. Cell Reports
- Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
- (2017) Wei Zhang et al. PLoS Pathogens
- ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
- (2017) Sara Baldanta et al. PLoS Pathogens
- Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress
- (2017) Jingjing Liang et al. PLoS Pathogens
- RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
- (2017) Takuma Yoshizumi et al. Scientific Reports
- In vivo Ebola virus infection leads to a strong innate response in circulating immune cells
- (2016) Ignacio S. Caballero et al. BMC GENOMICS
- Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species
- (2016) M. K. Deaton et al. JOURNAL OF VIROLOGY
- Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme
- (2016) Spencer Hill et al. MOLECULAR AND CELLULAR BIOLOGY
- TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS
- (2016) Young Bong Choi et al. MOLECULAR AND CELLULAR BIOLOGY
- ISG15 deficiency and increased viral resistance in humans but not mice
- (2016) Scott D. Speer et al. Nature Communications
- Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
- (2016) Chen Zhao et al. Nature Communications
- Ubc13: the Lys63 ubiquitin chain building machine
- (2016) Curtis D. Hodge et al. Oncotarget
- Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus
- (2016) Lu Dai et al. Oncotarget
- Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators
- (2016) Ye Ji Kim et al. PLoS Pathogens
- The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis
- (2016) Mark Swanson et al. Cancers
- Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin
- (2016) Jian Lei et al. VIROLOGICA SINICA
- The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
- (2015) Yahira M. Báez-Santos et al. ANTIVIRAL RESEARCH
- Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
- (2015) Daichao Xu et al. Autophagy
- A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance
- (2015) Jacqueline Smith et al. BMC GENOMICS
- Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase
- (2015) Patricia Domingues et al. JOURNAL OF GENERAL VIROLOGY
- Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
- (2015) Sarah R. Jacobs et al. JOURNAL OF VIROLOGY
- Biology of Zika Virus Infection in Human Skin Cells
- (2015) Rodolphe Hamel et al. JOURNAL OF VIROLOGY
- Endothelial Cell Proteomic Response toRickettsia conoriiInfection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/Cadherin Signaling
- (2015) Yingxin Zhao et al. MOLECULAR & CELLULAR PROTEOMICS
- The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication
- (2015) Chringma Sherpa et al. NUCLEIC ACIDS RESEARCH
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis
- (2015) Jun-Bao Fan et al. Scientific Reports
- Isg15 controls p53 stability and functions
- (2014) Yi-Fu Huang et al. CELL CYCLE
- A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis
- (2014) S. El Maadidi et al. JOURNAL OF IMMUNOLOGY
- Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
- (2014) Xianqin Zhang et al. NATURE
- Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export
- (2014) Matthew Woods et al. Retrovirology
- Viral OTU Deubiquitinases: A Structural and Functional Comparison
- (2014) Ben A. Bailey-Elkin et al. PLoS Pathogens
- Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
- (2014) Kiira Ratia et al. PLoS Pathogens
- IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
- (2013) HyeonJoo Cheon et al. EMBO JOURNAL
- ISG15 Is Counteracted by Vaccinia Virus E3 Protein and Controls the Proinflammatory Response against Viral Infection
- (2013) B. Eduardo-Correia et al. JOURNAL OF VIROLOGY
- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
- (2013) Linn Fagerberg et al. MOLECULAR & CELLULAR PROTEOMICS
- Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming
- (2013) Elena Maspero et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Interferon-induced ISG15 pathway: an ongoing virus–host battle
- (2013) Chen Zhao et al. TRENDS IN MICROBIOLOGY
- Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
- (2013) Helen M. Lazear et al. PLoS Pathogens
- Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
- (2013) Hari B Kamadurai et al. eLife
- The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis
- (2013) Yasufumi Kaneda OncoImmunology
- The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells
- (2012) Hwa Young Yim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Differential Responses of Immune Cells to Type I Interferon Contribute to Host Resistance to Viral Infection
- (2012) Thomas Baranek et al. Cell Host & Microbe
- K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites
- (2012) Frédérick A Mallette et al. CELL RESEARCH
- HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells
- (2012) Diede Oudshoorn et al. PLoS One
- Over-expression of mitochondrial antiviral signaling protein inhibits coxsackievirus B3 infection by enhancing type-I interferons production
- (2012) Qing-Meng Zhang et al. Virology Journal
- Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
- (2011) Elena Maspero et al. EMBO REPORTS
- Human dendritic cells promote an antiviral immune response when stimulated by CVT-E002
- (2011) Ramses Ilarraza et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
- (2011) Woong Kim et al. MOLECULAR CELL
- Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains
- (2011) M. Akutsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease
- (2011) T. W. James et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag
- (2011) Matthew W Woods et al. Retrovirology
- ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
- (2011) Jianfeng Dai et al. Virology Journal
- Inhibition of Hepatitis C Virus Replication by IFN-Mediated ISGylation of HCV-NS5A
- (2010) M.-J. Kim et al. JOURNAL OF IMMUNOLOGY
- Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein
- (2010) Y. Tang et al. JOURNAL OF IMMUNOLOGY
- Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein
- (2010) G. A. Versteeg et al. JOURNAL OF VIROLOGY
- The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon
- (2010) K. M. Graef et al. JOURNAL OF VIROLOGY
- Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
- (2010) H. X. Shi et al. MOLECULAR AND CELLULAR BIOLOGY
- The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15
- (2010) Larissa A. Durfee et al. MOLECULAR CELL
- ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells
- (2010) C. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antiviral Properties of ISG15
- (2010) Deborah J. Lenschow Viruses-Basel
- Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
- (2009) David Komander et al. EMBO REPORTS
- A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities
- (2009) Renuka K. Pandya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antiviral Activity of Innate Immune Protein ISG15
- (2009) Ronald N. Harty et al. Journal of Innate Immunity
- Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex
- (2009) Hari B. Kamadurai et al. MOLECULAR CELL
- Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
- (2009) H. Cheon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acute induction of cell death-related IFN stimulated genes (ISG) differentiates highly from moderately virulent CSFV strains
- (2009) Patricia Renson et al. VETERINARY RESEARCH
- Characterization of Polyubiquitin Chain Structure by Middle-down Mass Spectrometry
- (2008) Ping Xu et al. ANALYTICAL CHEMISTRY
- The RCC1 superfamily: From genes, to function, to disease
- (2008) Ouadah Hadjebi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Regulation of the Nuclear Factor (NF)-κB Pathway by ISGylation
- (2008) Miki Minakawa et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response
- (2008) Oxana A. Malakhova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Whole-Genome Expression Profiling Reveals That Inhibition of Host Innate Immune Response Pathways by Ebola Virus Can Be Reversed by a Single Amino Acid Change in the VP35 Protein
- (2008) A. L. Hartman et al. JOURNAL OF VIROLOGY
- ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
- (2008) A. Okumura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15
- (2008) Susana Guerra et al. PLoS Pathogens
- UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I
- (2007) Kei-Ichiro Arimoto et al. MOLECULAR IMMUNOLOGY
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