Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation

MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination

(2020) Wei Liu et al.   Viruses-Basel

USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I

(2020) Xinyue Tao et al.   PLoS Pathogens

A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination

(2020) Yuan-Qin Min et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impairment of the deISGylation activity of FMDV Lpro causes attenuation in vitro and in vivo

(2020) Gisselle N. Medina et al.   JOURNAL OF VIROLOGY

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease

(2020) Brendan T Freitas et al.   ACS Infectious Diseases

Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity

(2020) GuanQun Liu et al.   IMMUNITY

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay

(2020) Eleni Pitsillou et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Conserved strategies for pathogen evasion of cGAS–STING immunity

(2020) James B Eaglesham et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

(2020) Theresa Klemm et al.   EMBO JOURNAL

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

(2020) Wioletta Rut et al.   Science Advances

To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system

(2019) Adam Hage et al.   JOURNAL OF GENERAL VIROLOGY

14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases

(2019) Soham Gupta et al.   PLoS Pathogens

Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

(2019) Gianni Gori Savellini et al.   PLoS Pathogens

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

(2018) Maria T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

RIG-I Detects Kaposi’s Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner

(2018) Yugen Zhang et al.   mBio

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

(2018) Marios G. Koliopoulos et al.   Nature Communications

Subgenomic flaviviral RNAs: What do we know after the first decade of research

(2018) Andrii Slonchak et al.   ANTIVIRAL RESEARCH

Seneca Valley Virus 3C protease negatively regulates the type I interferon pathway by acting as a viral deubiquitinase

(2018) Qiao Xue et al.   ANTIVIRAL RESEARCH

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

(2018) Jacint G. Sanchez et al.   JOURNAL OF MOLECULAR BIOLOGY

The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation

(2018) Christine Zimmermann et al.   JOURNAL OF VIROLOGY

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

(2018) Junsu Ban et al.   Viruses-Basel

ISGylation – a key to lock the cell gates for preventing the spread of threats

(2017) Carolina Villarroya-Beltri et al.   JOURNAL OF CELL SCIENCE

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5

(2017) Hong-Lei Zhang et al.   JOURNAL OF VIROLOGY

The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling

(2017) Cindy Chiang et al.   JOURNAL OF VIROLOGY

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease

(2017) Florine E.M. Scholte et al.   Cell Reports

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

(2016) Jie Li et al.   Cellular & Molecular Immunology

Viral evasion of DNA-stimulated innate immune responses

(2016) Maria H Christensen et al.   Cellular & Molecular Immunology

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

(2016) Jacint G. Sanchez et al.   Cell Reports

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

(2016) Helene Minyi Liu et al.   EBioMedicine

Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

(2015) Shanping He et al.   MOLECULAR CELL

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5

(2014) Meredith E. Davis et al.   Cell Host & Microbe

Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Products

(2014) Y. Nan et al.   JOURNAL OF VIROLOGY

Downregulation of MicroRNA miR-526a by Enterovirus Inhibits RIG-I-Dependent Innate Immune Response

(2014) C. Xu et al.   JOURNAL OF VIROLOGY

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25

(2014) E.-K. Pauli et al.   Science Signaling

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase

(2013) Y. Xing et al.   JOURNAL OF GENERAL VIROLOGY

ISG15 Is Counteracted by Vaccinia Virus E3 Protein and Controls the Proinflammatory Response against Viral Infection

(2013) B. Eduardo-Correia et al.   JOURNAL OF VIROLOGY

Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I

(2013) G. Gori-Savellini et al.   JOURNAL OF VIROLOGY

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15

(2012) Z. Sun et al.   JOURNAL OF VIROLOGY

Amino Acid Requirements for MDA5 and LGP2 Recognition by Paramyxovirus V Proteins: a Single Arginine Distinguishes MDA5 from RIG-I

(2012) K. R. Rodriguez et al.   JOURNAL OF VIROLOGY

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease

(2011) Y. A. Karpe et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of RIG-I-Mediated Signaling by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Deubiquitinase ORF64

(2011) K.-S. Inn et al.   JOURNAL OF VIROLOGY

Arterivirus and Nairovirus Ovarian Tumor Domain-Containing Deubiquitinases Target Activated RIG-I To Control Innate Immune Signaling

(2011) P. B. van Kasteren et al.   JOURNAL OF VIROLOGY

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

(2011) M. Akutsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

(2011) Scott W. Werneke et al.   PLoS Pathogens

Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein

(2011) Junyi Jiang et al.   Protein & Cell

RNA Structures Required for Production of Subgenomic Flavivirus RNA

(2010) A. Funk et al.   JOURNAL OF VIROLOGY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Kaposi's Sarcoma-Associated Herpesvirus Encodes a Viral Deubiquitinase

(2009) C. M. Gonzalez et al.   JOURNAL OF VIROLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

(2008) Gorben P. Pijlman et al.   Cell Host & Microbe

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

(2008) M. U. Gack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA