Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Amino acid metabolism as drug target in autoimmune diseases

(2019) Giada Mondanelli et al.   AUTOIMMUNITY REVIEWS

Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease

(2019) Giada Mondanelli et al.   Frontiers in Immunology

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

(2019) Marco Gargaro et al.   Frontiers in Immunology

New 4-Amino-1,2,3-Triazole Inhibitors of Indoleamine 2,3-Dioxygenase Form a Long-Lived Complex with the Enzyme and Display Exquisite Cellular Potency

(2018) Julie Anne Christine Alexandre et al.   CHEMBIOCHEM

Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T-cell subsets in multiple sclerosis patients

(2018) Priscila M. Sacramento et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1

(2018) Ariel Lewis-Ballester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

(2018) Micah T. Nelp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the IDO1/TDO2–KYN–AhR Pathway for Cancer Immunotherapy – Challenges and Opportunities

(2018) Jae Eun Cheong et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes

(2018) Ciriana Orabona et al.   TRENDS IN MOLECULAR MEDICINE

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis

(2017) Laura Negrotto et al.   JOURNAL OF IMMUNOLOGY

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

(2017) Alice Coletti et al.   MedChemComm

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

(2017) Ariel Lewis-Ballester et al.   Nature Communications

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

(2017) Tobias V. Lanz et al.   Scientific Reports

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes

(2017) Giada Mondanelli et al.   Frontiers in Immunology

Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells

(2017) Jae-Myung Yoo et al.   Redox Biology

A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE

(2017) Hsi-Ju Wei et al.   Scientific Reports

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Immune cells from patients with psoriasis are defective in inducing indoleamine 2,3-dioxygenase expression in response to inflammatory stimuli

(2016) M. Llamas-Velasco et al.   BRITISH JOURNAL OF DERMATOLOGY

Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis

(2016) Shyi-Jou Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1

(2016) Elisa Albini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis

(2016) Jie Wen et al.   Journal of Neuroimmune Pharmacology

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

(2016) Claudia Volpi et al.   NEUROPHARMACOLOGY

Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

(2015) Lucia García-Lara et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Tryptophan-Degrading Enzymes in Tumoral Immune Resistance

(2015) Nicolas van Baren et al.   Frontiers in Immunology

N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury

(2014) H. Zhou et al.   JOURNAL OF NEUROSCIENCE

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA-4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3-Dioxygenase Pathway

(2014) Adam P. Cribbs et al.   Arthritis & Rheumatology

Immunological Relevance of the Coevolution of IDO1 and AHR

(2014) Merja Jaronen et al.   Frontiers in Immunology

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

The aryl hydrocarbon receptor: fine-tuning the immune-response

(2010) Marc Veldhoen et al.   CURRENT OPINION IN IMMUNOLOGY

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

(2010) Zhao-Lai Dai   Frontiers in Bioscience-Landmark

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

(2010) Francesca Fallarino et al.   NATURE MEDICINE

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-acetylserotonin activates TrkB receptor in a circadian rhythm

(2010) Sung-Wuk Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Evidence of immune system melatonin production by two pineal melatonin deficient mice, C57BL/6 and Swiss strains

(2009) Araceli Gómez-Corvera et al.   JOURNAL OF PINEAL RESEARCH

Inhibitory Substrate Binding Site of Human Indoleamine 2,3-Dioxygenase

(2009) Changyuan Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

(2008) Jessica B. Katz et al.   IMMUNOLOGICAL REVIEWS

Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism

(2008) Mariola Matysiak et al.   JOURNAL OF NEUROIMMUNOLOGY

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES