Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function

(2021) Bridie Jane Goggins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium

(2021) Stephanie A. Cevallos et al.   mBio

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

(2021) András Maifeld et al.   Nature Communications

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

(2021) Peter A.C. Wing et al.   Cell Reports

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

GSTO1‐1 is an upstream suppressor of M2 macrophage skewing and HIF‐1α‐induced eosinophilic airway inflammation

(2020) Leon A. Sokulsky et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mucosal inflammation downregulates PHD1 expression promoting a barrier‐protective HIF‐1α response in ulcerative colitis patients

(2020) Eric Brown et al.   FASEB JOURNAL

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

(2020) Yutaka Nakamura et al.   Mucosal Immunology

Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier

(2020) Jhimmy Talbot et al.   NATURE

The effects of daily fasting hours on shaping gut microbiota in mice

(2020) Linghao Li et al.   BMC MICROBIOLOGY

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

(2020) Isha H. Jain et al.   CELL

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin

(2020) Ruth X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

(2020) Inês Mesquita et al.   Cell Reports

High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease

(2020) Jee-Yon Lee et al.   Cell Host & Microbe

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α

(2020) Chao Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The HIF target ATG9A is Essential for Epithelial Barrier Function and Tight Junction Biogenesis

(2020) Alexander S. Dowdell et al.   MOLECULAR BIOLOGY OF THE CELL

Dietary fiber metabolites regulate innate lymphoid cell responses

(2020) Ali Sepahi et al.   Mucosal Immunology

Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice

(2020) Shanna L. Ashley et al.   Science Translational Medicine

Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function

(2020) Kevin C. Allan et al.   Cell Stem Cell

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

(2020) Emma U. Hammarlund et al.   SCIENCE

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection

(2019) Bernard C. Lo et al.   JOURNAL OF IMMUNOLOGY

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

(2019) Juan Liu et al.   IMMUNITY

Lipopolysaccharide and interferon-γ team up to activate HIF-1α via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells

(2019) Iván Parra-Izquierdo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression

(2019) Stephanie Muenchau et al.   MOLECULAR AND CELLULAR BIOLOGY

Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome

(2019) Lehao Ren et al.   VIROLOGY

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

(2019) José Luís Fachi et al.   Cell Reports

HIF-1α regulates IL-1β and IL-17 in sarcoidosis

(2019) Jaya Talreja et al.   eLife

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands

(2019) Blanda Di Luccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease

(2019) Tingting Qian et al.   MOLECULAR IMMUNOLOGY

Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes

(2019) Lihua Sun et al.   Frontiers in Immunology

Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity

(2019) Eunyoung Chun et al.   IMMUNITY

Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway

(2019) Ruijuan Guan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

(2019) José Luís Fachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier

(2018) En-De Hu et al.   CELLULAR IMMUNOLOGY

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells

(2018) Jennifer K. Bando et al.   IMMUNITY

Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

(2018) Marco Colonna   IMMUNITY

Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction

(2018) Tuo Shao et al.   JOURNAL OF HEPATOLOGY

HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis

(2018) Akil Hammami et al.   Scientific Reports

Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

(2018) Aspen T Reese et al.   eLife

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

(2018) Kairui Mao et al.   NATURE

Induction of HIF-1α by HIV-1 Infection in CD4+ T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

(2018) Gabriel Duette et al.   mBio

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury

(2018) Qiang Zhu et al.   Cell Death & Disease

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation

(2018) Zuo-Lin Li et al.   KIDNEY INTERNATIONAL

Nitric Oxide Modulates Macrophage Responses toMycobacterium tuberculosisInfection through Activation of HIF-1α and Repression of NF-κB

(2017) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

(2017) Leon Zheng et al.   JOURNAL OF IMMUNOLOGY

HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages

(2017) Ting Wang et al.   MEDIATORS OF INFLAMMATION

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model

(2017) Tingting Chen et al.   Food & Function

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

(2017) Xinkun Guo et al.   Emerging Microbes & Infections

Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

(2017) Annelies Geirnaert et al.   Scientific Reports

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Targeting hypoxia-mediated mucin 2 production as a therapeutic strategy for mucinous tumors

(2016) Ashok K. Dilly et al.   Translational Research

Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia

(2016) Victoria I. Holden et al.   mBio

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

(2016) Erica Miraglia et al.   Scientific Reports

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Complementarity and redundancy of IL-22-producing innate lymphoid cells

(2015) Lucille C Rankin et al.   NATURE IMMUNOLOGY

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

(2015) Di Fan et al.   NATURE MEDICINE

Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea

(2014) Isabel Moreno-Indias et al.   EUROPEAN RESPIRATORY JOURNAL

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection

(2014) Xiaohuan Guo et al.   IMMUNITY

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

CCR6 identifies lymphoid tissue inducer cells within cryptopatches

(2010) A. Lügering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection

(2008) Helene A. Haeberle et al.   PLoS One

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY