Cerebroprotection for Acute Ischemic Stroke: Looking Ahead

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

(2020) Michael D Hill et al.   LANCET

Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain

(2020) Yujiao Lu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

(2020) Joon-Hyuk Lee et al.   NATURE

Stroke Treatment Academic Industry Roundtable X

(2019) Sean I. Savitz et al.   STROKE

Neuroprotection and vasculoprotection using genetically targeted protease-ligands

(2019) Padmesh S. Rajput et al.   BRAIN RESEARCH

Remote Ischemic Conditioning as an Additional Treatment for Acute Ischemic Stroke

(2019) Thijs R.J. Landman et al.   STROKE

Neuron‐generated thrombin induces a protective astrocyte response via protease activated receptors

(2019) Padmesh S. Rajput et al.   GLIA

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

(2018) Ranjeet K. Sinha et al.   BLOOD

MicroRNA-based therapeutics in central nervous system injuries

(2018) Ping Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy

(2018) Chuanjie Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reproducibility of preclinical animal research improves with heterogeneity of study samples

(2018) Bernhard Voelkl et al.   PLOS BIOLOGY

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical

(2018) Gregory J. Bix et al.   Translational Stroke Research

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ

(2018) Patrick Lyden et al.   ANNALS OF NEUROLOGY

Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia

(2018) Patrick D Lyden et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System

(2018) Ciro De Luca et al.   Frontiers in Cellular Neuroscience

Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases

(2017) Ciro De Luca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Validating and comparing stroke prognosis scales

(2017) Terence J. Quinn et al.   NEUROLOGY

Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery

(2017) Changhong Xing et al.   PROGRESS IN NEUROBIOLOGY

Translational Stroke Research

(2017) Francesca Bosetti et al.   STROKE

Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials

(2017) Joseph P. Broderick et al.   STROKE

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in ThrombosisHighlights

(2016) John H. Griffin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A review on animal models of stroke: An update

(2016) Anil Kumar et al.   BRAIN RESEARCH BULLETIN

Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke

(2016) Oana M Dumitrascu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exosomes in stroke pathogenesis and therapy

(2016) Zheng Gang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)

(2016) Patrick Lyden et al.   STROKE

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection

(2016) Patrick Lyden et al.   STROKE

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic

(2016) John H. Griffin et al.   THROMBOSIS RESEARCH

Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update

(2016) Sarah K. McCann et al.   Translational Stroke Research

Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy

(2016) Italo Linfante et al.   Translational Stroke Research

Tyrosine Kinase Inhibitor as a new Therapy for Ischemic Stroke and other Neurologic Diseases: is there any Hope for a Better Outcome?

(2015) Iwona Gagalo et al.   Current Neuropharmacology

Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema

(2015) Jilin Bai et al.   International Journal of Stroke

Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

(2014) Emily S Sena et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protease activated receptor-1 mediates cytotoxicity during ischemia using in vivo and in vitro models

(2014) P.S. Rajput et al.   NEUROSCIENCE

Transcranial Laser Therapy in Acute Stroke Treatment

(2014) Werner Hacke et al.   STROKE

Found in Translation

(2014) Ulrich Dirnagl et al.   STROKE

Direct Thrombin Inhibitor Argatroban Reduces Stroke Damage in 2 Different Models

(2014) Patrick Lyden et al.   STROKE

Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation

(2014) Changhong Xing et al.   STROKE

Hypothermia for acute ischaemic stroke

(2013) Tzu-Ching Wu et al.   LANCET NEUROLOGY

Induction of Cooling With a Passive Head and Neck Cooling Device

(2013) Sven Poli et al.   STROKE

The secretome signature of reactive glial cells and its pathological implications

(2012) Mithilesh Kumar Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

(2012) B. Chen et al.   JOURNAL OF NEUROSCIENCE

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Statistical Analysis of the Primary Outcome in Acute Stroke Trials

(2012) Philip M.W. Bath et al.   STROKE

Contemporary Outcome Measures in Acute Stroke Research

(2012) Kennedy R. Lees et al.   STROKE

RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research

(2012) Paul A. Lapchak et al.   Translational Stroke Research

Neuroprotective features of mesenchymal stem cells

(2011) Antonio Uccelli et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Bone Marrow Mesenchymal Stem Cells: Agents of Immunomodulation and Neuroprotection

(2011) Ibrahim Kassis et al.   Current Stem Cell Research & Therapy

Neuroprotection in acute ischemic stroke - current status

(2010) E. Auriel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

(2010) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Mechanisms of action, physiological effects, and complications of hypothermia

(2009) Kees H. Polderman   CRITICAL CARE MEDICINE

Recent advances in pharmacologic neuroprotection

(2009) Jean Mantz et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

The neurovascular unit in the setting of stroke

(2009) G. J. del Zoppo   JOURNAL OF INTERNAL MEDICINE

Effectiveness and Safety of Transcranial Laser Therapy for Acute Ischemic Stroke

(2009) Justin A. Zivin et al.   STROKE

Empirical Evidence of Bias in the Design of Experimental Stroke Studies

(2008) Nicolas A. Crossley et al.   STROKE

Good Laboratory Practice

(2008) Malcolm R. Macleod et al.   STROKE