Article
Neurosciences
Jonas Blixt, Yutong Song, Michael Wanecek, Eli Gunnarson
Summary: Erythropoietin (EPO) has neuroprotective effects in models of central nervous system injury such as traumatic brain injury (TBI) and ischemic stroke. Previous studies have shown that EPO can preserve astrocyte function and decrease brain edema in TBI. In this study, the effects of EPO on astrocytes in an in vitro model of ischemia were explored, and it was found that EPO increased glutamate uptake, restored intracellular acidification, and increased lactate release, suggesting its potential contribution to neuroprotection in ischemic stroke and brain ischemia secondary to TBI.
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Chengya Dong, Shaohong Wen, Shunying Zhao, Si Sun, Shangfeng Zhao, Wen Dong, Pingxin Han, Qingfang Chen, Ting Gong, Wentao Chen, Wenqian Liu, Xiangrong Liu
Summary: Salidroside has been shown to improve long-term functional outcomes in ischemic stroke by inhibiting reactive astrocyte proliferation, ameliorating glial scar formation, and potentially acting through the Akt/GSK-3 beta pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Haiyun Guo, Zhen Zhang, Tingting Gu, Doutong Yu, Yanru Shi, Zejun Gao, Zhongheng Wang, Wenming Liu, Ze Fan, Wugang Hou, Huaning Wang, Yanhui Cai
Summary: This study found that Salvianolic acid B (SAB) has a neuroprotective effect on brain reperfusion injury by accelerating glycogenolysis in astrocytes. Inhibition of glycogenolysis weakens the neuroprotective effect of SAB.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mauricio Muleiro Alvarez, Felipe Esparza Salazar, Thomas Rodriguez, Francesco D'Egidio, Cesar V. Borlongan, Jea-Young Lee
Summary: This study investigates the role of extracellular vesicles in endogenous repair within the neurovascular unit after ischemic stroke. The findings suggest that CD63 exosomes are spatially and temporally associated with glial activation, neurogenesis, and angiogenesis, indicating their potential contribution to the repair of the neurovascular unit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Helene Roumes, Ursule Dumont, Stephane Sanchez, Leslie Mazuel, Jordy Blanc, Gerard Raffard, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Lactate has shown neuroprotective effects in a neonatal hypoxia-ischemia model, reducing brain lesion volume rapidly and efficiently. Lactate metabolism plays a key role in this protection, and lactate administration holds promise as an effective therapy for neonatal HI insult.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Shuqi Jiang, Huifang Wang, Qiuping Zhou, Qian Li, Nan Liu, Zhenggong Li, Chunbo Chen, Yiyu Deng
Summary: The study showed that Melatonin (MEL) can shift A1 astrocytes towards A2, increase myelin protein expression, reduce axonal hypomyelination, and improve neurological function in septic neonatal rats.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Neurosciences
Mina Borbor, Dongpei Yin, Ulf Brockmeier, Chen Wang, Marius Doeckel, Matthias Pillath-Eilers, Britta Kaltwasser, Dirk M. Hermann, Egor Dzyubenko
Summary: This study reveals that astrocytes play a crucial role in the maintenance of neuronal networks and their dysfunction can contribute to neurodegeneration. The researchers found that ischemia-reperfusion induces metabolic reprogramming in astrocytes, resulting in mitochondrial dysfunction and synaptic degeneration. Inhibiting STAT3 signaling pathway and increasing glycogen content in astrocytes can prevent synaptic degeneration.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Seong-Eun Kim, Hee-Sun Kim
Summary: This study investigated the neuroprotective effects of NKT in a Parkinson's disease mouse model. The results showed that NKT restored motor impairment and dopaminergic neuronal loss, increased the expression of neurotrophic factors, and inhibited inflammation and oxidative stress. Additionally, the study found that NKT acted through astrocytic Nrf2 and its downstream antioxidant molecules.
Review
Pharmacology & Pharmacy
Anil Ahsan, Mengru Liu, Yanrong Zheng, Wenping Yan, Lin Pan, Yue Li, Shijia Ma, Xingxian Zhang, Ming Cao, Zhanxun Wu, Weiwei Hu, Zhong Chen, Xiangnan Zhang
Summary: Stroke is a major cause of death and disability, with its complex pathological mechanisms posing challenges to effective therapy. Autophagy plays a critical role in cellular homeostasis and survival, with both protective and harmful effects on neuronal cells during ischemic injury. Naturally derived compounds have been found to modulate autophagy and provide neuroprotection against stroke, suggesting potential applications in treatment strategies.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Article
Biochemistry & Molecular Biology
Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Lee
Summary: The present study found that a diet containing morin can prevent motor dysfunction and dopaminergic neuronal damage in a mouse model of Parkinson's disease. It can also significantly reduce neuroinflammation. In vitro studies showed that morin exerts its anti-inflammatory effects by blocking the ERK-p65 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kyung Hee Lee, Myeounghoon Cha, Bae Hwan Lee
Summary: This article discusses the role of glia in protecting neurons from oxidative injury and maintaining antioxidant defense mechanisms in the brain, as well as the essential crosstalk between glia and neurons to maintain redox balance for protection against oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tianyanxin Sun, Tania L. Gonzalez, Nan Deng, Rosemarie DiPentino, Ekaterina L. Clark, Bora Lee, Jie Tang, Yizhou Wang, Barry R. Stripp, Changfu Yao, Hsian-Rong Tseng, S. Ananth Karumanchi, Alexander F. Koeppel, Stephen D. Turner, Charles R. Farber, Stephen S. Rich, Erica T. Wang, John Williams, Margareta D. Pisarska
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Connie W. Y. Ha, Anthony Martin, Gregory D. Sepich-Poore, Baochen Shi, Yizhou Wang, Kenneth Gouin, Gregory Humphrey, Karenina Sanders, Yasiru Ratnayake, Kelvin S. L. Chan, Gustaf Hendrick, J. R. Caldera, Christian Arias, Jacob E. Moskowitz, Shannan J. Ho Sui, Shaohong Yang, David Underhill, Matthew J. Brady, Simon Knott, Kelly Kaihara, Michael J. Steinbaugh, Huiying Li, Dermot P. B. McGovern, Rob Knight, Phillip Fleshner, Suzanne Devkota
Article
Gastroenterology & Hepatology
Ce Li, Zhenzi Peng, Yizhou Wang, Gloria Lam, Nicholas Nissen, Jie Tang, Xiaopu Yuan, Michael Lewis, Mark I. Greene, Stephen J. Pandol, Qiang Wang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic and deadly form of human cancer. This study identified a novel signaling mechanism involving YAP1-mediated expression of ECT2, which is elevated in PDAC and associated with poor patient survival. ECT2 is essential for PDAC growth and metastasis, highlighting its critical role in promoting pancreatic cancer progression. This research provides insights into the development of novel approaches for early detection and treatment of PDAC.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Oncology
Tom M. Thomas, Ken Miyaguchi, Lincoln A. Edwards, Hongqiang Wang, Hassen Wollebo, Li Aiguo, Ramachandran Murali, Yizhou Wang, Daniel Braas, Justin S. Michael, Allen M. Andres, Miqin Zhang, Kamel Khalili, Roberta A. Gottlieb, J. Manuel Perez, John S. Yu
Summary: ASNS gene is copy-number amplified in most glioblastomas, associated with decreased survival. ASNS overexpression leads to metabolic alterations, enhancing cell proliferation, spread, and resistance to stress. This metabolic vulnerability could be therapeutically exploited.
MOLECULAR CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang
Summary: Pulmonary mesenchymal cells play critical roles in lung development and disease states in both mice and humans, showing high heterogeneity and subtype-specific transcriptomic differences which contribute to matrix gene expression in fibrosis. Comparative analysis reveals conserved transcriptomic signatures in orthologous subpopulations of murine and human lung mesenchymal cells, enhancing our understanding of mesenchymal cell diversity in lung development and disease conditions.
Article
Cardiac & Cardiovascular Systems
Yen-Nien Lin, Thassio Mesquita, Lizbeth Sanchez, Yin-Huei Chen, Weixin Liu, Chang Li, Russell Rogers, Yizhou Wang, Xinling Li, Di Wu, Rui Zhang, Ahmed Ibrahim, Eduardo Marban, Eugenio Cingolani
Summary: The study demonstrated that extracellular vesicles secreted by cardiosphere-derived cells exerted significant effects in improving cardiac function, reducing cardiac inflammation, and suppressing arrhythmias in an arrhythmogenic cardiomyopathy murine model.
EUROPEAN HEART JOURNAL
(2021)
Article
Genetics & Heredity
Tania L. Gonzalez, Laura E. Eisman, Nikhil Joshi, Amy E. Flowers, Di Wu, Yizhou Wang, Chintda Santiskulvong, Jie Tang, Rae A. Buttle, Erica Sauro, Ekaterina L. Clark, Rosemarie DiPentino, Caroline A. Jefferies, Jessica L. Chan, Yayu Lin, Yazhen Zhu, Yalda Afshar, Hsian-Rong Tseng, Kent Taylor, John Williams, Margareta D. Pisarska
Summary: This study investigates miRNA changes in healthy human placentae across gestation, identifying differentially expressed miRNAs and providing a baseline for future studies on monitoring maternal-fetal health. The research uses next-generation sequencing to characterize the miRNome of first and third trimester human placentae from a large cohort, shedding light on the epigenetic differences in different stages of pregnancy.
Article
Immunology
Syairah Hanan Shaharuddin, Victoria Wang, Roberta S. Santos, Andrew Gross, Yizhou Wang, Harneet Jawanda, Yi Zhang, Wohaib Hasan, Gustavo Garcia, Vaithilingaraja Arumugaswami, Dhruv Sareen
Summary: The COVID-19 pandemic has had a significant impact worldwide, targeting the pancreas as a potential site for the virus to enter cells and potentially causing acute pancreatitis. Using iPSC technology, it was investigated how SARS-CoV-2 infection could affect pancreatic cells, revealing that the virus can directly infect pancreatic cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ting Xie, Vrishika Kulur, Ningshan Liu, Nan Deng, Yizhou Wang, Simon Coyle Rowan, Changfu Yao, Guanling Huang, Xue Liu, Forough Taghavifar, Jiurong Liang, Cory Hogaboam, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble
Summary: Recent studies have shown that impaired renewal of type 2 alveolar epithelial cells (ATII) in IPF patients and mice with defective ATII can lead to severe pulmonary fibrosis. Growth hormone receptor (GHR) expression, mainly found in mesenchymal cells, is significantly decreased in IPF lungs, but higher levels of GHR expression are associated with better lung function in IPF patients. The findings suggest that a previously unidentified mesenchymal paracrine signaling via GHR can support ATII progenitor cell renewal and limit the severity of lung fibrosis.
Article
Reproductive Biology
Amy E. Flowers, Tania L. Gonzalez, Nikhil Joshi, Laura E. Eisman, Ekaterina L. Clark, Rae A. Buttle, Erica Sauro, Rosemarie DiPentino, Yayu Lin, Di Wu, Yizhou Wang, Chintda Santiskulvong, Jie Tang, Bora Lee, Tianyanxin Sun, Jessica L. Chan, Erica T. Wang, Caroline Jefferies, Kate Lawrenson, Yazhen Zhu, Yalda Afshar, Hsian-Rong Tseng, John Williams, Margareta D. Pisarska
Summary: The study reveals sexually dimorphic miRNA expression in the placenta during different stages of gestation, with more pronounced differences in the first trimester. Female placentas exhibit a higher number of differentially expressed miRNAs throughout gestation, indicating sexually dimorphic miRNA abundance across human pregnancy. These findings are crucial for understanding placental function and investigating sex differences in placental biology.
BIOLOGY OF REPRODUCTION
(2022)
Article
Immunology
Gantsetseg Tumurkhuu, Duygu Ercan Laguna, Richard E. Moore, Jorge Contreras, Gabriela De Los Santos, Luisa Akaveka, Erica N. Montano, Yizhou Wang, Mariko Ishimori, Swamy Venuturupalli, Lindsy J. Forbess, Barry R. Stripp, Daniel J. Wallace, Caroline A. Jefferies
Summary: Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). Studies suggest that neutrophils and NETs play a significant role in inducing ER stress response and lung hemorrhage in the Pristane-induced model.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Geoffrey de Couto, Thassio Mesquita, Xiaokang Wu, Alex Rajewski, Feng Huang, Akbarshakh Akhmerov, Na Na, Di Wu, Yizhou Wang, Liang Li, My Tran, Peter Kilfoil, Eugenio Cingolani, Eduardo Marban
Summary: This study suggests that inflammation plays a significant role in endothelial dysfunction in HFpEF. CDCs, heart-derived cell products, have been proven to have anti-inflammatory therapeutic properties. Infusion of CDCs reduces oxidative stress, restores eNOS levels, decreases monocyte levels, and restores the expression of multiple disease-associated genes, thus improving vascular reactivity. The beneficial effects of CDCs support the hypothesis that inflammation of endothelial cells is a major driver of HFpEF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Immunology
Xue Liu, Yan Geng, Jiurong Liang, Ana Lucia Coelho, Changfu Yao, Nan Deng, Yizhou Wang, Kristy Dai, Guanling Huang, Ting Xie, Ningshan Liu, Simon C. Rowan, Forough Taghavifar, Vrishika Kulur, Zhenqiu Liu, Barry R. Stripp, Cory M. Hogaboam, Dianhua Jiang, Paul W. Noble
Summary: This study suggests that HER2 signaling may play a crucial role in fibroblast invasion and lung fibrosis in IPF, making it a potential target for therapeutic intervention.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jiurong Liang, Guanling Huang, Xue Liu, Forough Taghavifar, Ningshan Liu, Yizhou Wang, Nan Deng, Changfu Yao, Ting Xie, Vrishika Kulur, Kristy Dai, Ankita Burman, Simon C. Rowan, S. Samuel Weigt, John Belperio, Barry Stripp, William C. Parks, Dianhua Jiang, Paul W. Noble
Summary: This study identified a deficiency of the zinc transporter SLC39A8 (ZIP8) in Type 2 alveolar epithelial cells (AEC2s) from both idiopathic pulmonary fibrosis (IPF) lungs and lungs of old mice, which is associated with impaired AEC2 renewal capacity and enhanced lung fibrosis. The regulation of AEC2 progenitor function by ZIP8 is dependent on SIRT1. Replenishment with exogenous zinc and activation of SIRT1 promote self-renewal and differentiation of AEC2s, and therapeutic strategies targeting zinc metabolism and SIRT1 signaling could potentially improve AEC2 progenitor function and mitigate fibrogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Obstetrics & Gynecology
Jessica L. Chan, Tania L. Gonzalez, Amy E. Flowers, Rae A. Buttle, Yizhou Wang, Chintda Santiskulvong, Xue-Ying Song, Rosemarie DiPentino, Ekaterina L. Clark, Anna Dorfman, Allynson Novoa, Ricardo Azziz, Margareta D. Pisarska
REPRODUCTIVE SCIENCES
(2022)