Reproducibility of preclinical animal research improves with heterogeneity of study samples

More than 3Rs: the importance of scientific validity for harm-benefit analysis of animal research

(2017) Hanno Würbel   LAB ANIMAL

Addressing reproducibility in single-laboratory phenotyping experiments

(2017) Neri Kafkafi et al.   NATURE METHODS

Measurement error and the replication crisis

(2017) Eric Loken et al.   SCIENCE

Detecting and avoiding likely false-positive findings - a practical guide

(2016) Wolfgang Forstmeier et al.   BIOLOGICAL REVIEWS

What does research reproducibility mean?

(2016) Steven N. Goodman et al.   Science Translational Medicine

Reproducibility Crisis: Are We Ignoring Reaction Norms?

(2016) Bernhard Voelkl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

(2015) Gemma Llovera et al.   Science Translational Medicine

Meta-research: Evaluation and Improvement of Research Methods and Practices

(2015) John P. A. Ioannidis et al.   PLOS BIOLOGY

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Impact of Temporal Variation on Design and Analysis of Mouse Knockout Phenotyping Studies

(2014) Natasha A. Karp et al.   PLoS One

Accounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes

(2014) Angela Reitsma et al.   Trials

Assessing potential sources of clustering in individually randomised trials

(2013) Brennan C Kahan et al.   BMC Medical Research Methodology

Hypothermia for acute ischaemic stroke

(2013) Tzu-Ching Wu et al.   LANCET NEUROLOGY

Revised standards for statistical evidence

(2013) V. E. Johnson   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Obtaining evidence by a single well-powered trial or several modestly powered trials

(2012) Joanna IntHout et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Analysis of multicentre trials with continuous outcomes: when and how should we account for centre effects?

(2012) Brennan C. Kahan et al.   STATISTICS IN MEDICINE

Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): A Paradigm Shift in Studies of Infarct Size Limitation

(2011) David J. Lefer et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Dopamine agonists in animal models of Parkinson’s disease: A systematic review and meta-analysis

(2011) Evelien D.M. Rooke et al.   PARKINSONISM & RELATED DISORDERS

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

(2011) S. Helene Richter et al.   PLoS One

The Newest Synthesis: Understanding the Interplay of Evolutionary and Ecological Dynamics

(2011) T. W. Schoener   SCIENCE

Systematic variation improves reproducibility of animal experiments

(2010) S Helene Richter et al.   NATURE METHODS

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Design effect in multicenter studies: gain or loss of power?

(2009) Emilie Vierron et al.   BMC Medical Research Methodology

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS