Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

Single Cell RNA-Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy

(2021) Ping Yuan et al.   CIRCULATION

Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy

(2020) Nadine Suffee et al.   CIRCULATION RESEARCH

Genetic Animal Models for Arrhythmogenic Cardiomyopathy

(2020) Brenda Gerull et al.   Frontiers in Physiology

Molecular mechanisms of arrhythmogenic cardiomyopathy

(2019) Karyn M. Austin et al.   Nature Reviews Cardiology

Deletion of transcription factor AP‐2α gene attenuates fibroblast differentiation into myofibroblast

(2019) Gracious R. Ross et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

(2018) David T Paik et al.   CIRCULATION RESEARCH

Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity

(2018) Tatjana Dorn et al.   EMBO JOURNAL

Arrhythmogenicity of fibro-fatty infiltrations

(2018) Tim De Coster et al.   Scientific Reports

TFAP2 transcription factors are regulators of lipid droplet biogenesis

(2018) Cameron C Scott et al.   eLife

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation

(2018) Clayton E. Friedman et al.   Cell Stem Cell

Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies

(2017) Shahrzad Sepehrkhouy et al.   HEART RHYTHM

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions

(2017) Xiaoping Bao et al.   Nature Protocols

Arrhythmogenic Right Ventricular Cardiomyopathy

(2017) Domenico Corrado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria

(2017) Nadine Suffee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin GeneNovelty and Significance

(2016) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

(2016) Christopher D Richardson et al.   NATURE BIOTECHNOLOGY

Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate

(2016) Wei Guo et al.   Cell Death & Disease

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Maturation-Based Model of Arrhythmogenic Right Ventricular Dysplasia Using Patient-Specific Induced Pluripotent Stem Cells

(2015) Jian-Yan Wen et al.   CIRCULATION JOURNAL

Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family MembersCLINICAL PERSPECTIVE

(2015) Judith A. Groeneweg et al.   Circulation-Cardiovascular Genetics

Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy

(2015) E. Sommariva et al.   EUROPEAN HEART JOURNAL

The ARVD/C Genetic Variants Database: 2014 Update

(2015) Elisabetta Lazzarini et al.   HUMAN MUTATION

Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation

(2015) Yukiko Yamaguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family MembersCLINICAL PERSPECTIVE

(2015) Judith A. Groeneweg et al.   Circulation-Cardiovascular Genetics

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

(2015) Manuel Stemmer et al.   PLoS One

Epicardium-to-fat transition in injured heart

(2014) Qiaozhen Liu et al.   CELL RESEARCH

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Validation of noise models for single-cell transcriptomics

(2014) Dominic Grün et al.   NATURE METHODS

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

(2014) Miao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

(2013) Suet Nee Chen et al.   CIRCULATION RESEARCH

Modeling of Arrhythmogenic Right Ventricular Cardiomyopathy With Human Induced Pluripotent Stem Cells

(2013) Oren Caspi et al.   Circulation-Cardiovascular Genetics

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

(2013) Changsung Kim et al.   NATURE

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

(2012) Alexander von Gise et al.   CIRCULATION RESEARCH

Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy

(2012) Dongrui Ma et al.   EUROPEAN HEART JOURNAL

Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts

(2011) Stephanie A. Matthes et al.   CELL COMMUNICATION AND ADHESION

Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

(2011) James J.H. Chong et al.   Cell Stem Cell

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

(2009) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Myocardial infarction induces embryonic reprogramming of epicardial c-kit+ cells: Role of the pericardial fluid

(2009) Federica Limana et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium

(2008) Bin Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor   Signaling

(2008) D. Koinuma et al.   MOLECULAR AND CELLULAR BIOLOGY