Journal
ELIFE
Volume 7, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.36330
Keywords
-
Categories
Funding
- NCCR Chemical Biology [51NF40_125781]
- Swiss SystemsX.ch Initiative - LipidX [51RT-0_145726]
- Human Frontier Science Program Fellowship
- Canadian Institutes of Health Research Fellowship
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [31003A_159479]
- Swiss National Science Foundation (SNF) [31003A_159479, 51NF40_125781] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years. We previously found that the Wnt signaling directly controls lipid droplet formation, linking the cell storage capacity to the established functions of Wnt in development and differentiation. In the present paper, we report that Wnt-induced lipid droplet biogenesis does not depend on the canonical TCF/LEF transcription factors. Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a 'master' regulator of lipid droplet biogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available