标题
Structure of an AMPK complex in an inactive, ATP-bound state
作者
关键词
-
出版物
SCIENCE
Volume 373, Issue 6553, Pages 413-419
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-07-23
DOI
10.1126/science.abe7565
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
- (2020) Pietri Puustinen et al. Autophagy
- AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System
- (2020) Jingyue Jia et al. MOLECULAR CELL
- The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine
- (2018) Pooja Sadana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments
- (2018) June Ereño-Orbea et al. JOURNAL OF MOLECULAR BIOLOGY
- Keeping the home fires burning: AMP-activated protein kinase
- (2018) D. Grahame Hardie Journal of the Royal Society Interface
- Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)
- (2018) Xin Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states
- (2018) Yan Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
- (2017) Xin Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress
- (2017) Xiaorong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification
- (2017) Fan Liu et al. Nature Communications
- Metformin extends C. elegans lifespan through lysosomal pathway
- (2017) Jie Chen et al. eLife
- AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours
- (2016) Fiona A. Ross et al. FEBS Journal
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Probing the enzyme kinetics, allosteric modulation and activation of 1- and 2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators
- (2015) F. Rajamohan et al. BIOCHEMICAL JOURNAL
- Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome
- (2015) Traci L Marin et al. BMC Systems Biology
- A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin–Calmodulin Binding Peptide Interaction
- (2015) Somnath Mukherjee et al. JOURNAL OF MOLECULAR BIOLOGY
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry
- (2015) Fan Liu et al. NATURE METHODS
- MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments
- (2014) Meena Choi et al. BIOINFORMATICS
- The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
- (2014) Chen-Song Zhang et al. Cell Metabolism
- Structural basis of AMPK regulation by adenine nucleotides and glycogen
- (2014) Xiaodan Li et al. CELL RESEARCH
- Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
- (2014) John W. Scott et al. CHEMISTRY & BIOLOGY
- Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
- (2014) Matthew F. Calabrese et al. STRUCTURE
- AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
- (2013) Graeme J. Gowans et al. Cell Metabolism
- AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
- (2013) Ya-Lin Zhang et al. Cell Metabolism
- Coordinated regulation of AMPK activity by multiple elements in the α-subunit
- (2013) Feng-Jiao Xin et al. CELL RESEARCH
- Nutrient Sensing, Metabolism, and Cell Growth Control
- (2013) Hai-Xin Yuan et al. MOLECULAR CELL
- Conserved regulatory elements in AMPK
- (2013) Lei Chen et al. NATURE
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2013) Rachelle R. Landgraf et al. STRUCTURE
- Structural basis of AMPK regulation by small molecule activators
- (2013) Bing Xiao et al. Nature Communications
- Generating conformation-specific synthetic antibodies to trap proteins in selected functional states
- (2012) Marcin Paduch et al. METHODS
- AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
- (2012) Lei Chen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- T Cell Receptor-Like Recognition of Tumor In Vivo by Synthetic Antibody Fragment
- (2012) Keith R. Miller et al. PLoS One
- Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain
- (2011) Noriko Handa et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- Structure of mammalian AMPK and its regulation by ADP
- (2011) Bing Xiao et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
- (2011) J. S. Oakhill et al. SCIENCE
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Development of a Novel Cross-linking Strategy for Fast and Accurate Identification of Cross-linked Peptides of Protein Complexes
- (2010) Athit Kao et al. MOLECULAR & CELLULAR PROTEOMICS
- A synergistic approach to protein crystallization: Combination of a fixed-arm carrier with surface entropy reduction
- (2010) Andrea F. Moon et al. PROTEIN SCIENCE
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
- (2009) S. Fogarty et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease
- (2009) Aaron K. F. Wong et al. CLINICAL SCIENCE
- AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance
- (2009) Nicolas Dzamko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK in Health and Disease
- (2009) Gregory R. Steinberg et al. PHYSIOLOGICAL REVIEWS
- The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
- (2009) X. J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The AMP-regulated kinase family: Enigmatic targets for diabetes therapy
- (2008) G RUTTER et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started