Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

(2017) Xin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Targeting an energy sensor to treat diabetes

(2017) D. Grahame Hardie   SCIENCE

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation

(2015) Yvonne Oligschlaeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

(2014) John W. Scott et al.   CHEMISTRY & BIOLOGY

Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex

(2014) Shumei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

(2014) Matthew F. Calabrese et al.   STRUCTURE

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Coordinated regulation of AMPK activity by multiple elements in the α-subunit

(2013) Feng-Jiao Xin et al.   CELL RESEARCH

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Conserved regulatory elements in AMPK

(2013) Lei Chen et al.   NATURE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

(2012) Lei Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY