Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis

The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants

(2020) Mark J. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation

(2020) Guadalupe Ortiz-Muñoz et al.   JOURNAL OF CLINICAL INVESTIGATION

THE PHOSPHODIESTERASE INHIBITOR ENSIFENTRINE REDUCES PRODUCTION OF PRO-INFLAMMATORY MEDIATORS IN WELL-DIFFERENTIATED BRONCHIAL EPITHELIAL CELLS BY INHIBITING PDE4.

(2020) Mark Turner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Aminophylline promotes mitochondrial biogenesis in human pulmonary bronchial epithelial cells

(2019) Guoshi Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains

(2019) Asmahan Abu-Arish et al.   JOURNAL OF GENERAL PHYSIOLOGY

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele

(2019) Peter G. Middleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lumacaftor/ivacaftor reduces exacerbations in adults homozygous for Phe508del mutation with severe lung disease

(2019) Koliarne Tong et al.   Journal of Cystic Fibrosis

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6

(2018) Timothy B. Johnstone et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

[Ca2+ ]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice

(2018) Haruka Kogiso et al.   EXPERIMENTAL PHYSIOLOGY

Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1

(2018) Haruka Kogiso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes

(2018) Shailesh R. Agarwal et al.   Frontiers in Pharmacology

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial

(2018) Klaus F Rabe et al.   Lancet Respiratory Medicine

VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

(2018) Dominic Keating et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

(2018) Heng Li et al.   Frontiers in Pharmacology

A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia

(2017) Haruka Kogiso et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Adenylyl cyclase signalling complexes – Pharmacological challenges and opportunities

(2017) Michelle L. Halls et al.   PHARMACOLOGY & THERAPEUTICS

Experimental and mathematical analysis of cAMP nanodomains

(2017) Christian Lohse et al.   PLoS One

Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

(2017) Michael-Claude G. Beltejar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia

(2016) Mark J. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility

(2016) Daniel P. Cook et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of CFTR in epithelial physiology

(2016) Vinciane Saint-Criq et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

(2016) Chiara Brullo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

(2016) Gudio Veit et al.   MOLECULAR BIOLOGY OF THE CELL

The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)

(2016) KUO YAN et al.   Molecular Medicine Reports

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Translating the genetics of cystic fibrosis to personalized medicine

(2016) Harriet Corvol et al.   Translational Research

Mechanisms Restricting Diffusion of Intracellular cAMP

(2016) Shailesh R. Agarwal et al.   Scientific Reports

Progress in therapies for cystic fibrosis

(2016) Kris De Boeck et al.   Lancet Respiratory Medicine

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor

(2016) Michael J. Watson et al.   Scientific Reports

Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure

(2015) Jean Tyrrell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Defective Innate Immunity and Hyperinflammation in Newborn Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferret Lungs

(2015) Nicholas W. Keiser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

cCMP and cUMP occur in vivo

(2015) Heike Bähre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholesterol Modulates CFTR Confinement in the Plasma Membrane of Primary Epithelial Cells

(2015) Asmahan Abu-Arish et al.   BIOPHYSICAL JOURNAL

Tiotropium Respimat® in cystic fibrosis: Phase 3 and Pooled phase 2/3 randomized trials

(2015) Felix Ratjen et al.   Journal of Cystic Fibrosis

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015) Claire E. Wainwright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

(2014) Katharine H. Abbott-Banner et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

CFTR: cystic fibrosis and beyond

(2014) M. A. Mall et al.   EUROPEAN RESPIRATORY JOURNAL

PDE7A1 hydrolyzes cCMP

(2014) Maike Monzel et al.   FEBS LETTERS

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors

(2014) Chiara Brullo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Role of Membrane Microdomains in Compartmentation of cAMP Signaling

(2014) Shailesh R. Agarwal et al.   PLoS One

Testing Two Different Doses of Tiotropium Respimat® in Cystic Fibrosis: Phase 2 Randomized Trial Results

(2014) Judy M. Bradley et al.   PLoS One

Potentiator ivacaftor abrogates pharmacological correction of  F508 CFTR in cystic fibrosis

(2014) D. M. Cholon et al.   Science Translational Medicine

Comparison of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Ciliary Beat Frequency Activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in Primary Sinonasal Epithelial Cultures

(2014) Bryant T. Conger et al.   JAMA Otolaryngology-Head & Neck Surgery

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) S. Vamsee Raju et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

(2013) James A. Lambert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sildenafil Acts as Potentiator and Corrector of CFTR but Might be not Suitable for the Treatment of CF Lung Disease

(2013) Geraldine Leier et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD

(2013) Mark T. Dransfield et al.   CHEST

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

(2013) Elise Blanchard et al.   FASEB JOURNAL

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

(2013) Gerd Döring et al.   Journal of Cystic Fibrosis

Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?

(2013) Kavisha Arora et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition

(2013) Didem Demirbas et al.   PLoS One

Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α and Chemokine Production by Human Lung Parenchyma

(2013) Amparo Buenestado et al.   PLoS One

Correction of Chloride Transport and Mislocalization of CFTR Protein by Vardenafil in the Gastrointestinal Tract of Cystic Fibrosis Mice

(2013) Barbara Dhooghe et al.   PLoS One

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

(2012) J Milara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice

(2012) Bob Lubamba et al.   Journal of Cystic Fibrosis

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

cAMP regulation of airway smooth muscle function

(2012) Charlotte K. Billington et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis

(2012) Sabrina Noel et al.   Frontiers in Pharmacology

Anion secretion by a model epithelium: more lessons from Calu-3

(2011) J. Shan et al.   Acta Physiologica

Oxidative stress and antioxidant therapy in cystic fibrosis

(2011) Francesco Galli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-platelet therapy: phosphodiesterase inhibitors

(2011) Paolo Gresele et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide

(2011) A Buenestado et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sensitivity of Chloride Efflux vs. Transepithelial Measurements in Mixed CF and Normal Airway Epithelial Cell Populations

(2011) Beate Illek et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Defective adenosine-stimulated cAMP production in cystic fibrosis airway epithelia: a novel role for CFTR in cell signaling

(2011) Michael J. Watson et al.   FASEB JOURNAL

Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated

(2011) Daniel Reinecke et al.   FEBS LETTERS

Inactivation of Multidrug Resistance Proteins Disrupts Both Cellular Extrusion and Intracellular Degradation of cAMP

(2011) M. Xie et al.   MOLECULAR PHARMACOLOGY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Cyclic AMP Control Measured in Two Compartments in HEK293 Cells: Phosphodiesterase KM Is More Important than Phosphodiesterase Localization

(2011) Karina Matthiesen et al.   PLoS One

SERCA2 Regulates Non-CF and CF Airway Epithelial Cell Response to Ozone

(2011) Shama Ahmad et al.   PLoS One

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice

(2010) B. Lubamba et al.   EUROPEAN RESPIRATORY JOURNAL

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners

(2010) Chunying Li et al.   Integrative Biology

Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes

(2010) Shailesh R. Agarwal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains

(2010) Himabindu Penmatsa et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms and Function of DUOX in Epithelia of the Lung

(2009) Horst Fischer   ANTIOXIDANTS & REDOX SIGNALING

Prostaglandin EP3 receptor superactivates adenylyl cyclase via the G q /PLC/Ca 2+ pathway in a lipid raft-dependent manner

(2009) Kumiko Yamaoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

(2009) Cecile Terrenoire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of the Cystic Fibrosis Transmembrane Conductance Channel in Human Airway Smooth Muscle

(2008) Marie-Claire Michoud et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes

(2008) Jérôme Leroy et al.   CIRCULATION RESEARCH

Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells

(2008) Dong Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Preclinical Evidence that Sildenafil and Vardenafil Activate Chloride Transport in Cystic Fibrosis

(2007) Bob Lubamba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE