Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

Dual Role of NOX2 in Respiratory Syncytial Virus- and Sendai Virus-Induced Activation of NF- B in Airway Epithelial Cells

(2014) K. Fink et al.   JOURNAL OF IMMUNOLOGY

Adenosine activation of A2B receptor(s) is essential for stimulated epithelial ciliary motility and clearance

(2011) Diane S. Allen-Gipson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells

(2011) Saima Muzaffar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

(2010) Dina Schneider et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Goblet Cells Are Derived from aFOXJ1-Expressing Progenitor in a Human Airway Epithelium

(2010) Jonathan Turner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette Smoke Exposure Impairs Respiratory Epithelial Ciliogenesis

(2010) Edwin Tamashiro et al.   American Journal of Rhinology & Allergy

Cilia Motility and Structure in Primary and Secondary Ciliary Dyskinesia

(2010) Miguel Armengot et al.   American Journal of Rhinology & Allergy

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

(2010) Andrea Wohlsen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of IL-13 on Mucociliary Differentiation of Pediatric Asthmatic Bronchial Epithelial Cells

(2010) Surendran Thavagnanam et al.   PEDIATRIC RESEARCH

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Long-Term Cigarette Smoke Exposure in a Mouse Model of Ciliated Epithelial Cell Function

(2009) Samantha M. Simet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Involvement of IL-13 in Tobacco Smoke–Induced Changes in the Structure and Function of Rat Intrapulmonary Airways

(2009) Philip R. Cooper et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Receptor Activation of NADPH Oxidases

(2009) Andreas Petry et al.   ANTIOXIDANTS & REDOX SIGNALING

Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury

(2009) J Cortijo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Purinergic receptors in airway epithelia

(2009) Eduardo R Lazarowski et al.   CURRENT OPINION IN PHARMACOLOGY

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

(2009) Peter MA Calverley et al.   LANCET

Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency

(2009) Noam A. Cohen et al.   LARYNGOSCOPE

Direct effect of cigarette smoke on human pulmonary artery tension

(2009) Jose Luis Ortiz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

DNAI2 Mutations Cause Primary Ciliary Dyskinesia with Defects in the Outer Dynein Arm

(2008) Niki Tomas Loges et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A2BAdenosine Receptors Regulate the Mucus Clearance Component of the Lung's Innate Defense System

(2008) Brett M. Rollins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dual Oxidase 1 and 2 Expression in Airway Epithelium of Smokers and Patients with Mild/Moderate Chronic Obstructive Pulmonary Disease

(2008) Katsura Nagai et al.   ANTIOXIDANTS & REDOX SIGNALING

Foxj1 transcription factors are master regulators of the motile ciliogenic program

(2008) Xianwen Yu et al.   NATURE GENETICS

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE